Hixozide in therapy of tuberculosis of bronchi
The purpose of the article is to evaluate the efficacy and tolerability of the combined inhaled anti-TB preparation Hixozide for improving the effectiveness of medical treatment of patients suffering from tuberculosis of bronchus. Material and Methods. Hixozide (made in Russia), the active substance...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Saratov State Medical University
2014-06-01
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| Series: | Саратовский научно-медицинский журнал |
| Subjects: | |
| Online Access: | http://www.ssmj.ru/system/files/2014_02_293-300.pdf |
| _version_ | 1818665403810840576 |
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| author | Morozova T.l. Barinboym O.N. Doktorova N.P. Danilov A.N. |
| author_facet | Morozova T.l. Barinboym O.N. Doktorova N.P. Danilov A.N. |
| author_sort | Morozova T.l. |
| collection | DOAJ |
| description | The purpose of the article is to evaluate the efficacy and tolerability of the combined inhaled anti-TB preparation Hixozide for improving the effectiveness of medical treatment of patients suffering from tuberculosis of bronchus. Material and Methods. Hixozide (made in Russia), the active substance Hydroxymethylchinoxylindioxydum 100mg + Isoniazidum 250 mg, was delivered via inhalations using a compressor nebulizer within 21 days in the course of the complex chemotherapy. Inclusion criteria: newly diagnosed patients and patients with relapsed tuberculosis with the presence of tuberculousendobronchitis, drug sensitivity saved to isoniazid. Exclusion criteria: the state of preventing the appointment of adequate treatment, HIV-infection (group 1, n=30). The comparison group was consisted of patients receiving standard treatment in combination with inhaled administration of Isoniazid (group 2, n=21). Rezults. The clinical study has figured out: after a course of inhalations of Hixozide the clinical cure of bronchial tuberculosis occurs after the period of 2 months of treatment (according to the results of endoscopy of bronchi); more patients — 69.2% versus 38.1% in the comparison group, p=0,039 showed a positive trend during the nonspecific endobronchitis — 85,7% vs. 52,9%, p=0,017; the treatment and bacteriological conversion were achieved: 143±27 days in the first group vs. 164±32 days in the control group, p=0,019. Adverse reactions to Hixozide demanding its abolition occurred in 13,3%, they were stopped and did not affect the health of patients in the future. Conclusion. Inhaled Hixozide in the complex treatment of patients with tuberculosis accelerates clinical cure of tuberculosis of the bronchi, healing the lesions in the lung tissue and abacillation. |
| first_indexed | 2024-12-17T05:48:05Z |
| format | Article |
| id | doaj.art-3bdbd7578f2240929e7690330d1cf9e1 |
| institution | Directory Open Access Journal |
| issn | 2076-2518 |
| language | Russian |
| last_indexed | 2024-12-17T05:48:05Z |
| publishDate | 2014-06-01 |
| publisher | Saratov State Medical University |
| record_format | Article |
| series | Саратовский научно-медицинский журнал |
| spelling | doaj.art-3bdbd7578f2240929e7690330d1cf9e12022-12-21T22:01:15ZrusSaratov State Medical UniversityСаратовский научно-медицинский журнал2076-25182014-06-011022933003690Hixozide in therapy of tuberculosis of bronchiMorozova T.l.0Barinboym O.N.1Doktorova N.P.2Danilov A.N.3Saratov State Medical UniversitySaratov State Medical UniversitySaratov State Medical UniversitySaratov State Medical UniversityThe purpose of the article is to evaluate the efficacy and tolerability of the combined inhaled anti-TB preparation Hixozide for improving the effectiveness of medical treatment of patients suffering from tuberculosis of bronchus. Material and Methods. Hixozide (made in Russia), the active substance Hydroxymethylchinoxylindioxydum 100mg + Isoniazidum 250 mg, was delivered via inhalations using a compressor nebulizer within 21 days in the course of the complex chemotherapy. Inclusion criteria: newly diagnosed patients and patients with relapsed tuberculosis with the presence of tuberculousendobronchitis, drug sensitivity saved to isoniazid. Exclusion criteria: the state of preventing the appointment of adequate treatment, HIV-infection (group 1, n=30). The comparison group was consisted of patients receiving standard treatment in combination with inhaled administration of Isoniazid (group 2, n=21). Rezults. The clinical study has figured out: after a course of inhalations of Hixozide the clinical cure of bronchial tuberculosis occurs after the period of 2 months of treatment (according to the results of endoscopy of bronchi); more patients — 69.2% versus 38.1% in the comparison group, p=0,039 showed a positive trend during the nonspecific endobronchitis — 85,7% vs. 52,9%, p=0,017; the treatment and bacteriological conversion were achieved: 143±27 days in the first group vs. 164±32 days in the control group, p=0,019. Adverse reactions to Hixozide demanding its abolition occurred in 13,3%, they were stopped and did not affect the health of patients in the future. Conclusion. Inhaled Hixozide in the complex treatment of patients with tuberculosis accelerates clinical cure of tuberculosis of the bronchi, healing the lesions in the lung tissue and abacillation.http://www.ssmj.ru/system/files/2014_02_293-300.pdfHixozidetreatment of tuberculosistuberculosis of bronchi |
| spellingShingle | Morozova T.l. Barinboym O.N. Doktorova N.P. Danilov A.N. Hixozide in therapy of tuberculosis of bronchi Саратовский научно-медицинский журнал Hixozide treatment of tuberculosis tuberculosis of bronchi |
| title | Hixozide in therapy of tuberculosis of bronchi |
| title_full | Hixozide in therapy of tuberculosis of bronchi |
| title_fullStr | Hixozide in therapy of tuberculosis of bronchi |
| title_full_unstemmed | Hixozide in therapy of tuberculosis of bronchi |
| title_short | Hixozide in therapy of tuberculosis of bronchi |
| title_sort | hixozide in therapy of tuberculosis of bronchi |
| topic | Hixozide treatment of tuberculosis tuberculosis of bronchi |
| url | http://www.ssmj.ru/system/files/2014_02_293-300.pdf |
| work_keys_str_mv | AT morozovatl hixozideintherapyoftuberculosisofbronchi AT barinboymon hixozideintherapyoftuberculosisofbronchi AT doktorovanp hixozideintherapyoftuberculosisofbronchi AT danilovan hixozideintherapyoftuberculosisofbronchi |