Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project
We investigated the associations of different sedentary behaviors (SB) with gray matter volume and we tested whether SB related to gray matter volume is associated with intelligence. Methods: 99 children with overweight or obesity aged 8–11 years participated in this cross-sectional study. SB was me...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/4/1101 |
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| author | Juan Pablo Zavala-Crichton Irene Esteban-Cornejo Patricio Solis-Urra José Mora-Gonzalez Cristina Cadenas-Sanchez María Rodriguez-Ayllon Jairo H. Migueles Pablo Molina-Garcia Juan Verdejo-Roman Arthur F. Kramer Charles H. Hillman Kirk I. Erickson Andrés Catena Francisco B. Ortega |
| author_facet | Juan Pablo Zavala-Crichton Irene Esteban-Cornejo Patricio Solis-Urra José Mora-Gonzalez Cristina Cadenas-Sanchez María Rodriguez-Ayllon Jairo H. Migueles Pablo Molina-Garcia Juan Verdejo-Roman Arthur F. Kramer Charles H. Hillman Kirk I. Erickson Andrés Catena Francisco B. Ortega |
| author_sort | Juan Pablo Zavala-Crichton |
| collection | DOAJ |
| description | We investigated the associations of different sedentary behaviors (SB) with gray matter volume and we tested whether SB related to gray matter volume is associated with intelligence. Methods: 99 children with overweight or obesity aged 8–11 years participated in this cross-sectional study. SB was measured using the Youth Activity Profile-Spain questionnaire. T1-weighted images were acquired with a 3.0 T Magnetom Tim Trio system. Intelligence was assessed with the Kaufman Brief Test. Whole-brain voxel-wise multiple regression models were used to test the associations of each SB with gray matter volume. Results: Watching TV was associated with lower gray matter volume in six brain regions (β ranging −0.314 to −0.489 and cluster size 106 to 323 voxels; <i>p</i> < 0.001), playing video games in three brain regions (β ranging −0.391 to −0.359, and cluster size 96 to 461 voxels; <i>p</i> < 0.001) and total sedentary time in two brain regions (β ranging −0.341 to −0.352, and cluster size 897 to 2455 voxels; <i>p</i> < 0.001). No brain regions showed a significant positive association (all <i>p</i> > 0.05). Two brain regions were related, or borderline related, to intelligence. Conclusions: SB could have the potential to negatively influence brain structure and, in turn, intelligence in children with overweight/obesity. |
| first_indexed | 2024-03-10T20:30:48Z |
| format | Article |
| id | doaj.art-3bdc06d7f7ed4e07991fb1d132b0f90a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T20:30:48Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3bdc06d7f7ed4e07991fb1d132b0f90a2023-11-19T21:24:39ZengMDPI AGJournal of Clinical Medicine2077-03832020-04-0194110110.3390/jcm9041101Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains ProjectJuan Pablo Zavala-Crichton0Irene Esteban-Cornejo1Patricio Solis-Urra2José Mora-Gonzalez3Cristina Cadenas-Sanchez4María Rodriguez-Ayllon5Jairo H. Migueles6Pablo Molina-Garcia7Juan Verdejo-Roman8Arthur F. Kramer9Charles H. Hillman10Kirk I. Erickson11Andrés Catena12Francisco B. Ortega13PROFITH “PROmoting FITness and Health Through Physical Activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, 18071 Granada, SpainPROFITH “PROmoting FITness and Health Through Physical Activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, 18071 Granada, SpainPROFITH “PROmoting FITness and Health Through Physical Activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, 18071 Granada, SpainPROFITH “PROmoting FITness and Health Through Physical Activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, 18071 Granada, SpainPROFITH “PROmoting FITness and Health Through Physical Activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, 18071 Granada, SpainPROFITH “PROmoting FITness and Health Through Physical Activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, 18071 Granada, SpainPROFITH “PROmoting FITness and Health Through Physical Activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, 18071 Granada, SpainPROFITH “PROmoting FITness and Health Through Physical Activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, 18071 Granada, SpainMind, Brain and Behavior Research Center (CIMCYC), University of Granada, 18071 Granada, SpainDepartment of Psychology, Northeastern University, Boston, MA 02115, USADepartment of Psychology, Northeastern University, Boston, MA 02115, USABrain Aging & Cognitive Health Lab, Department of Psychology, University of Pittsburgh, 3601 Sennott Square, Pittsburgh, PA 15218, USADepartment of Experimental Psychology, Mind, Brain and Behavior Research Centre (CIMCYC), University of Granada, 18011 Granada, SpainPROFITH “PROmoting FITness and Health Through Physical Activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, 18071 Granada, SpainWe investigated the associations of different sedentary behaviors (SB) with gray matter volume and we tested whether SB related to gray matter volume is associated with intelligence. Methods: 99 children with overweight or obesity aged 8–11 years participated in this cross-sectional study. SB was measured using the Youth Activity Profile-Spain questionnaire. T1-weighted images were acquired with a 3.0 T Magnetom Tim Trio system. Intelligence was assessed with the Kaufman Brief Test. Whole-brain voxel-wise multiple regression models were used to test the associations of each SB with gray matter volume. Results: Watching TV was associated with lower gray matter volume in six brain regions (β ranging −0.314 to −0.489 and cluster size 106 to 323 voxels; <i>p</i> < 0.001), playing video games in three brain regions (β ranging −0.391 to −0.359, and cluster size 96 to 461 voxels; <i>p</i> < 0.001) and total sedentary time in two brain regions (β ranging −0.341 to −0.352, and cluster size 897 to 2455 voxels; <i>p</i> < 0.001). No brain regions showed a significant positive association (all <i>p</i> > 0.05). Two brain regions were related, or borderline related, to intelligence. Conclusions: SB could have the potential to negatively influence brain structure and, in turn, intelligence in children with overweight/obesity.https://www.mdpi.com/2077-0383/9/4/1101sedentarinessTV viewingmagnetic resonance imagingbraincognitionchildhood |
| spellingShingle | Juan Pablo Zavala-Crichton Irene Esteban-Cornejo Patricio Solis-Urra José Mora-Gonzalez Cristina Cadenas-Sanchez María Rodriguez-Ayllon Jairo H. Migueles Pablo Molina-Garcia Juan Verdejo-Roman Arthur F. Kramer Charles H. Hillman Kirk I. Erickson Andrés Catena Francisco B. Ortega Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project Journal of Clinical Medicine sedentariness TV viewing magnetic resonance imaging brain cognition childhood |
| title | Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project |
| title_full | Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project |
| title_fullStr | Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project |
| title_full_unstemmed | Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project |
| title_short | Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project |
| title_sort | association of sedentary behavior with brain structure and intelligence in children with overweight or obesity the activebrains project |
| topic | sedentariness TV viewing magnetic resonance imaging brain cognition childhood |
| url | https://www.mdpi.com/2077-0383/9/4/1101 |
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