Correlation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) with radiographic features of congestion in chest CT scan of patients with COVID-19
Abstract Background Given the importance of chest computed tomography (CT) to differentiate congestion from COVID-19 pneumonia, and considering the association of chest CT findings with cardiac biomarkers in patients with concomitant COVID-19 and heart failure, this study was conducted to identify t...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-07-01
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| Series: | The Egyptian Heart Journal |
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| Online Access: | https://doi.org/10.1186/s43044-023-00390-1 |
| _version_ | 1827899755974361088 |
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| author | Naghmeh Ziaie Seyed Mohammad Reza Tabatabaie Khadijeh Ezoji Ali Bijani Simin Mouodi |
| author_facet | Naghmeh Ziaie Seyed Mohammad Reza Tabatabaie Khadijeh Ezoji Ali Bijani Simin Mouodi |
| author_sort | Naghmeh Ziaie |
| collection | DOAJ |
| description | Abstract Background Given the importance of chest computed tomography (CT) to differentiate congestion from COVID-19 pneumonia, and considering the association of chest CT findings with cardiac biomarkers in patients with concomitant COVID-19 and heart failure, this study was conducted to identify the correlation between plasma NT-proBNP level and radiographic features of congestion in patients with COVID-19. This retrospective cohort research was carried out on adult hospitalized patients with COVID-19 and the plasma concentration of NT-proBNP was measured. The most important findings in chest CT have been considered to differentiate COVID-19 pneumonia from congestion. The study population was divided into two groups based on the presence of these imaging characteristics. Results Totally, 180 patients with a mean age of 59.6 ± 14.6 years were included in the research. The radiographic findings related to congestion have been found in chest CT of 107 (59.4%) patients. Mean plasma concentration of NT-proBNP in patients with and without radiographic features of congestion was 9886.5 ± 12,676 and 2079.9 ± 4209.3 pg/mL, respectively (p < 0.001). The area under the curve of plasma levels of NT-proBNP for identification of patients with COVID-19 who had pulmonary vein enlargement in chest CT was 0.765 (95% CI 0.688–0.842) and 0.731 (95% CI 0.648–0.813) for the individuals who had interlobar fissure thickening (p < 0.001). Conclusions The diagnostic accuracy of plasma NT-proBNP and its positive correlation with radiographic features of congestion in chest CT scan of patients with COVID-19 can be helpful for administering appropriate medications to prevent blood volume overload. |
| first_indexed | 2024-03-12T23:22:05Z |
| format | Article |
| id | doaj.art-3bdc25bb8e3d4707960b60084f5f4f45 |
| institution | Directory Open Access Journal |
| issn | 2090-911X |
| language | English |
| last_indexed | 2024-03-12T23:22:05Z |
| publishDate | 2023-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj.art-3bdc25bb8e3d4707960b60084f5f4f452023-07-16T11:20:18ZengSpringerOpenThe Egyptian Heart Journal2090-911X2023-07-017511610.1186/s43044-023-00390-1Correlation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) with radiographic features of congestion in chest CT scan of patients with COVID-19Naghmeh Ziaie0Seyed Mohammad Reza Tabatabaie1Khadijeh Ezoji2Ali Bijani3Simin Mouodi4Department of Cardiology, Babol University of Medical SciencesDepartment of Radiology, Babol University of Medical SciencesSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical SciencesSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical SciencesSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical SciencesAbstract Background Given the importance of chest computed tomography (CT) to differentiate congestion from COVID-19 pneumonia, and considering the association of chest CT findings with cardiac biomarkers in patients with concomitant COVID-19 and heart failure, this study was conducted to identify the correlation between plasma NT-proBNP level and radiographic features of congestion in patients with COVID-19. This retrospective cohort research was carried out on adult hospitalized patients with COVID-19 and the plasma concentration of NT-proBNP was measured. The most important findings in chest CT have been considered to differentiate COVID-19 pneumonia from congestion. The study population was divided into two groups based on the presence of these imaging characteristics. Results Totally, 180 patients with a mean age of 59.6 ± 14.6 years were included in the research. The radiographic findings related to congestion have been found in chest CT of 107 (59.4%) patients. Mean plasma concentration of NT-proBNP in patients with and without radiographic features of congestion was 9886.5 ± 12,676 and 2079.9 ± 4209.3 pg/mL, respectively (p < 0.001). The area under the curve of plasma levels of NT-proBNP for identification of patients with COVID-19 who had pulmonary vein enlargement in chest CT was 0.765 (95% CI 0.688–0.842) and 0.731 (95% CI 0.648–0.813) for the individuals who had interlobar fissure thickening (p < 0.001). Conclusions The diagnostic accuracy of plasma NT-proBNP and its positive correlation with radiographic features of congestion in chest CT scan of patients with COVID-19 can be helpful for administering appropriate medications to prevent blood volume overload.https://doi.org/10.1186/s43044-023-00390-1Coronavirus infectionsCongestionBiomarkersNT-proBNP |
| spellingShingle | Naghmeh Ziaie Seyed Mohammad Reza Tabatabaie Khadijeh Ezoji Ali Bijani Simin Mouodi Correlation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) with radiographic features of congestion in chest CT scan of patients with COVID-19 The Egyptian Heart Journal Coronavirus infections Congestion Biomarkers NT-proBNP |
| title | Correlation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) with radiographic features of congestion in chest CT scan of patients with COVID-19 |
| title_full | Correlation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) with radiographic features of congestion in chest CT scan of patients with COVID-19 |
| title_fullStr | Correlation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) with radiographic features of congestion in chest CT scan of patients with COVID-19 |
| title_full_unstemmed | Correlation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) with radiographic features of congestion in chest CT scan of patients with COVID-19 |
| title_short | Correlation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) with radiographic features of congestion in chest CT scan of patients with COVID-19 |
| title_sort | correlation of plasma n terminal pro brain natriuretic peptide nt probnp with radiographic features of congestion in chest ct scan of patients with covid 19 |
| topic | Coronavirus infections Congestion Biomarkers NT-proBNP |
| url | https://doi.org/10.1186/s43044-023-00390-1 |
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