Retinal microvascular and microstructural alterations in the diagnosis of meibomian gland dysfunction in severely obese population: a new approach
AIM: To study retinal microvascular and microstructural alterations in meibomian gland dysfunction (MGD) in severely obese population using optical coherence tomography angiography (OCTA). METHODS: Twelve MGD patients with severely obese population (PAT group; 24 eyes) and 12 healthy controls (HC gr...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2023-12-01
|
| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/en_publish/2023/12/20231209.pdf |
| _version_ | 1827672135356645376 |
|---|---|
| author | Hai Huang Xiao-Yu Wang Hong Wei Min Kang Jie Zou Qian Ling San-Hua Xu Hui Huang Xu Chen Yi-Xin Wang Yi Shao Yao Yu |
| author_facet | Hai Huang Xiao-Yu Wang Hong Wei Min Kang Jie Zou Qian Ling San-Hua Xu Hui Huang Xu Chen Yi-Xin Wang Yi Shao Yao Yu |
| author_sort | Hai Huang |
| collection | DOAJ |
| description | AIM: To study retinal microvascular and microstructural alterations in meibomian gland dysfunction (MGD) in severely obese population using optical coherence tomography angiography (OCTA). METHODS: Twelve MGD patients with severely obese population (PAT group; 24 eyes) and 12 healthy controls (HC group; 24 eyes) were recruited. OCTA images were segmented into five [superior (S), nasal (N), inferior (I), temporal (T), and central foveal (C)] or nine [inner superior (IS), outer superior (OS), inner nasal (IN), outer nasal (ON), inner inferior (II), outer inferior (OI), inner temporal (IT), outer temporal (OT), and C] subregions. The superficial vessel density (SVD), retinal thickness (RT), foveal avascular zone (FAZ) parameters, and retinal volume were measured. RESULTS: Visual acuity was significantly different between two groups (0.8±0.17 in PAT group vs 0.2±0.06 in HC group). SVD was significantly lower in PATs in N, T, OS, IN, OT, and ON. The area under the receiver operating characteristic curve (AUC) for T was 0.961 [95% confidence interval (CI): 0.908 to 1.000], for OS was 0.962 (95%CI: 0.915 to 1.000). RT was significantly lower in PATs in IS, OS, OI, OT, ON, IT, IN, and II. AUC for OT was 0.935 (95%CI: 0.870 to 0.999), for IS was 0.915 (95% CI: 0.838 to 0.992). Angiography results showed significantly lower area and perimeter of FAZ, SVD of the inner retina and both retinal volume and the average volume thickness in the PAT group. CONCLUSION: Vision may be affected in patients with MGD due to changes in retinal microvessels and microstructures. These changes detected by OCTA may be a potential marker for diagnosing MGD in severe obesity. |
| first_indexed | 2024-03-10T03:57:19Z |
| format | Article |
| id | doaj.art-3bdceed9b9ac4a6c85b674b6959e82ba |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-03-10T03:57:19Z |
| publishDate | 2023-12-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-3bdceed9b9ac4a6c85b674b6959e82ba2023-11-23T08:41:41ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982023-12-0116121977198510.18240/ijo.2023.12.0920231209Retinal microvascular and microstructural alterations in the diagnosis of meibomian gland dysfunction in severely obese population: a new approachHai Huang0Xiao-Yu Wang1Hong Wei2Min Kang3Jie Zou4Qian Ling5San-Hua Xu6Hui Huang7Xu Chen8Yi-Xin Wang9Yi Shao10Yao Yu11Yao Yu. Department of Endocrinology and Metabolism, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. 375135747@qq.com; Yi Shao. Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200433, China. freebee99@163.comDepartment of Endocrinology and Metabolism, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang 330006, Jiangxi Province, China; The First Clinical Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200433, China; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Branch of National Clinical Research Center for Ocular Disease, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200433, China; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Branch of National Clinical Research Center for Ocular Disease, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200433, China; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Branch of National Clinical Research Center for Ocular Disease, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200433, China; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Branch of National Clinical Research Center for Ocular Disease, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200433, China; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Branch of National Clinical Research Center for Ocular Disease, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200433, China; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Branch of National Clinical Research Center for Ocular Disease, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology and Visual Sciences, Maastricht University, Maastricht 6200MA, Limburg Province, NetherlandsSchool of Optometry and Vision Sciences, Cardiff University, Cardiff CF244HQ, United KingdomDepartment of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200433, China; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Branch of National Clinical Research Center for Ocular Disease, Nanchang 330006, Jiangxi Province, ChinaDepartment of Endocrinology and Metabolism, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang 330006, Jiangxi Province, ChinaAIM: To study retinal microvascular and microstructural alterations in meibomian gland dysfunction (MGD) in severely obese population using optical coherence tomography angiography (OCTA). METHODS: Twelve MGD patients with severely obese population (PAT group; 24 eyes) and 12 healthy controls (HC group; 24 eyes) were recruited. OCTA images were segmented into five [superior (S), nasal (N), inferior (I), temporal (T), and central foveal (C)] or nine [inner superior (IS), outer superior (OS), inner nasal (IN), outer nasal (ON), inner inferior (II), outer inferior (OI), inner temporal (IT), outer temporal (OT), and C] subregions. The superficial vessel density (SVD), retinal thickness (RT), foveal avascular zone (FAZ) parameters, and retinal volume were measured. RESULTS: Visual acuity was significantly different between two groups (0.8±0.17 in PAT group vs 0.2±0.06 in HC group). SVD was significantly lower in PATs in N, T, OS, IN, OT, and ON. The area under the receiver operating characteristic curve (AUC) for T was 0.961 [95% confidence interval (CI): 0.908 to 1.000], for OS was 0.962 (95%CI: 0.915 to 1.000). RT was significantly lower in PATs in IS, OS, OI, OT, ON, IT, IN, and II. AUC for OT was 0.935 (95%CI: 0.870 to 0.999), for IS was 0.915 (95% CI: 0.838 to 0.992). Angiography results showed significantly lower area and perimeter of FAZ, SVD of the inner retina and both retinal volume and the average volume thickness in the PAT group. CONCLUSION: Vision may be affected in patients with MGD due to changes in retinal microvessels and microstructures. These changes detected by OCTA may be a potential marker for diagnosing MGD in severe obesity.http://ies.ijo.cn/en_publish/2023/12/20231209.pdfsuperficial vessel densityretinal thicknessseverely obesitymeibomian gland dysfunctionoptical coherence tomography angiography |
| spellingShingle | Hai Huang Xiao-Yu Wang Hong Wei Min Kang Jie Zou Qian Ling San-Hua Xu Hui Huang Xu Chen Yi-Xin Wang Yi Shao Yao Yu Retinal microvascular and microstructural alterations in the diagnosis of meibomian gland dysfunction in severely obese population: a new approach International Journal of Ophthalmology superficial vessel density retinal thickness severely obesity meibomian gland dysfunction optical coherence tomography angiography |
| title | Retinal microvascular and microstructural alterations in the diagnosis of meibomian gland dysfunction in severely obese population: a new approach |
| title_full | Retinal microvascular and microstructural alterations in the diagnosis of meibomian gland dysfunction in severely obese population: a new approach |
| title_fullStr | Retinal microvascular and microstructural alterations in the diagnosis of meibomian gland dysfunction in severely obese population: a new approach |
| title_full_unstemmed | Retinal microvascular and microstructural alterations in the diagnosis of meibomian gland dysfunction in severely obese population: a new approach |
| title_short | Retinal microvascular and microstructural alterations in the diagnosis of meibomian gland dysfunction in severely obese population: a new approach |
| title_sort | retinal microvascular and microstructural alterations in the diagnosis of meibomian gland dysfunction in severely obese population a new approach |
| topic | superficial vessel density retinal thickness severely obesity meibomian gland dysfunction optical coherence tomography angiography |
| url | http://ies.ijo.cn/en_publish/2023/12/20231209.pdf |
| work_keys_str_mv | AT haihuang retinalmicrovascularandmicrostructuralalterationsinthediagnosisofmeibomianglanddysfunctioninseverelyobesepopulationanewapproach AT xiaoyuwang retinalmicrovascularandmicrostructuralalterationsinthediagnosisofmeibomianglanddysfunctioninseverelyobesepopulationanewapproach AT hongwei retinalmicrovascularandmicrostructuralalterationsinthediagnosisofmeibomianglanddysfunctioninseverelyobesepopulationanewapproach AT minkang retinalmicrovascularandmicrostructuralalterationsinthediagnosisofmeibomianglanddysfunctioninseverelyobesepopulationanewapproach AT jiezou retinalmicrovascularandmicrostructuralalterationsinthediagnosisofmeibomianglanddysfunctioninseverelyobesepopulationanewapproach AT qianling retinalmicrovascularandmicrostructuralalterationsinthediagnosisofmeibomianglanddysfunctioninseverelyobesepopulationanewapproach AT sanhuaxu retinalmicrovascularandmicrostructuralalterationsinthediagnosisofmeibomianglanddysfunctioninseverelyobesepopulationanewapproach AT huihuang retinalmicrovascularandmicrostructuralalterationsinthediagnosisofmeibomianglanddysfunctioninseverelyobesepopulationanewapproach AT xuchen retinalmicrovascularandmicrostructuralalterationsinthediagnosisofmeibomianglanddysfunctioninseverelyobesepopulationanewapproach AT yixinwang retinalmicrovascularandmicrostructuralalterationsinthediagnosisofmeibomianglanddysfunctioninseverelyobesepopulationanewapproach AT yishao retinalmicrovascularandmicrostructuralalterationsinthediagnosisofmeibomianglanddysfunctioninseverelyobesepopulationanewapproach AT yaoyu retinalmicrovascularandmicrostructuralalterationsinthediagnosisofmeibomianglanddysfunctioninseverelyobesepopulationanewapproach |