Nanocomposite of Ellagic Acid with Multi-Walled Carbon Nanotubes for the Simultaneous Voltammetric Detection of Six Biomolecules
In this proof-of-concept study, a highly sensitive electrochemical sensor using a graphite paste electrode modified with ellagic acid and multi-walled carbon nanotubes (MGPE/MWCNTs-EA) was developed for the simultaneous determination of six biomolecules: ascorbic acid (AA), dopamine (DA), uric acid...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | C |
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| Online Access: | https://www.mdpi.com/2311-5629/7/2/43 |
| _version_ | 1797535349085306880 |
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| author | Najmeh Sabbaghi Meissam Noroozifar Kagan Kerman |
| author_facet | Najmeh Sabbaghi Meissam Noroozifar Kagan Kerman |
| author_sort | Najmeh Sabbaghi |
| collection | DOAJ |
| description | In this proof-of-concept study, a highly sensitive electrochemical sensor using a graphite paste electrode modified with ellagic acid and multi-walled carbon nanotubes (MGPE/MWCNTs-EA) was developed for the simultaneous determination of six biomolecules: ascorbic acid (AA), dopamine (DA), uric acid (UA), tryptophan (Trp), xanthine (XA), and caffeine (CA). Differential pulse voltammetry (DPV) was performed at a potential range from 0.1–1.2 V vs. Ag/AgCl in phosphate electrolyte (pH 2.0). The modified GPE enabled the simultaneous determination of biomolecules under investigation in human urine and blood serum samples with detection limits ranging from 11–91 nM with recoveries of 94.0–106.0%. The electrochemical performance of the modified GPE for the analytes was stable and reproducible and checked with standard high performance liquid chromatography technique. The data suggested that the modified GPE provided a promising platform for routine quantitative determination of the biomolecules under investigation in quality control studies of real samples collected from food and pharmaceutical products. |
| first_indexed | 2024-03-10T11:43:12Z |
| format | Article |
| id | doaj.art-3bdcfda55b6147df93435beb80e4b80d |
| institution | Directory Open Access Journal |
| issn | 2311-5629 |
| language | English |
| last_indexed | 2024-03-10T11:43:12Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | C |
| spelling | doaj.art-3bdcfda55b6147df93435beb80e4b80d2023-11-21T18:16:34ZengMDPI AGC2311-56292021-05-01724310.3390/c7020043Nanocomposite of Ellagic Acid with Multi-Walled Carbon Nanotubes for the Simultaneous Voltammetric Detection of Six BiomoleculesNajmeh Sabbaghi0Meissam Noroozifar1Kagan Kerman2Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4, CanadaDepartment of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4, CanadaDepartment of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4, CanadaIn this proof-of-concept study, a highly sensitive electrochemical sensor using a graphite paste electrode modified with ellagic acid and multi-walled carbon nanotubes (MGPE/MWCNTs-EA) was developed for the simultaneous determination of six biomolecules: ascorbic acid (AA), dopamine (DA), uric acid (UA), tryptophan (Trp), xanthine (XA), and caffeine (CA). Differential pulse voltammetry (DPV) was performed at a potential range from 0.1–1.2 V vs. Ag/AgCl in phosphate electrolyte (pH 2.0). The modified GPE enabled the simultaneous determination of biomolecules under investigation in human urine and blood serum samples with detection limits ranging from 11–91 nM with recoveries of 94.0–106.0%. The electrochemical performance of the modified GPE for the analytes was stable and reproducible and checked with standard high performance liquid chromatography technique. The data suggested that the modified GPE provided a promising platform for routine quantitative determination of the biomolecules under investigation in quality control studies of real samples collected from food and pharmaceutical products.https://www.mdpi.com/2311-5629/7/2/43electrochemical sensormodified electrodeellagic acidmulti-walled carbon nanotubesvoltammetry |
| spellingShingle | Najmeh Sabbaghi Meissam Noroozifar Kagan Kerman Nanocomposite of Ellagic Acid with Multi-Walled Carbon Nanotubes for the Simultaneous Voltammetric Detection of Six Biomolecules C electrochemical sensor modified electrode ellagic acid multi-walled carbon nanotubes voltammetry |
| title | Nanocomposite of Ellagic Acid with Multi-Walled Carbon Nanotubes for the Simultaneous Voltammetric Detection of Six Biomolecules |
| title_full | Nanocomposite of Ellagic Acid with Multi-Walled Carbon Nanotubes for the Simultaneous Voltammetric Detection of Six Biomolecules |
| title_fullStr | Nanocomposite of Ellagic Acid with Multi-Walled Carbon Nanotubes for the Simultaneous Voltammetric Detection of Six Biomolecules |
| title_full_unstemmed | Nanocomposite of Ellagic Acid with Multi-Walled Carbon Nanotubes for the Simultaneous Voltammetric Detection of Six Biomolecules |
| title_short | Nanocomposite of Ellagic Acid with Multi-Walled Carbon Nanotubes for the Simultaneous Voltammetric Detection of Six Biomolecules |
| title_sort | nanocomposite of ellagic acid with multi walled carbon nanotubes for the simultaneous voltammetric detection of six biomolecules |
| topic | electrochemical sensor modified electrode ellagic acid multi-walled carbon nanotubes voltammetry |
| url | https://www.mdpi.com/2311-5629/7/2/43 |
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