T-Cadherin Deficiency Is Associated with Increased Blood Pressure after Physical Activity
T-cadherin is a regulator of blood vessel remodeling and angiogenesis, involved in adiponectin-mediated protective effects in the cardiovascular system and in skeletal muscles. GWAS study has previously demonstrated a SNP in the <i>Cdh13</i> gene to be associated with hypertension. Howev...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/18/14204 |
| Summary: | T-cadherin is a regulator of blood vessel remodeling and angiogenesis, involved in adiponectin-mediated protective effects in the cardiovascular system and in skeletal muscles. GWAS study has previously demonstrated a SNP in the <i>Cdh13</i> gene to be associated with hypertension. However, the role of T-cadherin in regulating blood pressure has not been experimentally elucidated. Herein, we generated Cdh13<sup>∆Exon3</sup> mice lacking exon 3 in the <i>Cdh13</i> gene and described their phenotype. Cdh13<sup>∆Exon3</sup> mice exhibited normal gross morphology, life expectancy, and breeding capacity. Meanwhile, their body weight was considerably lower than of WT mice. When running on a treadmill, the time spent running and the distance covered by Cdh13<sup>∆Exon3</sup> mice was similar to that of WT. The resting blood pressure in Cdh13<sup>∆Exon3</sup> mice was slightly higher than in WT, however, upon intensive physical training their systolic blood pressure was significantly elevated. While adiponectin content in the myocardium of Cdh13<sup>∆Exon3</sup> and WT mice was within the same range, adiponectin plasma level was 4.37-fold higher in Cdh13<sup>∆Exon3</sup> mice. Moreover, intensive physical training augmented the AMPK phosphorylation in the skeletal muscles and myocardium of Cdh13<sup>∆Exon3</sup> mice as compared to WT. Our data highlight a critically important role of T-cadherin in regulation of blood pressure and stamina in mice, and may shed light on the pathogenesis of hypertension. |
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| ISSN: | 1661-6596 1422-0067 |