The Double-Edged Proteins in Cancer Proteomes and the Generation of Induced Tumor-Suppressing Cells (iTSCs)

Unlike a prevalent expectation that tumor cells secrete tumor-promoting proteins and stimulate the progression of neighboring tumor cells, accumulating evidence indicates that the role of tumor-secreted proteins is double-edged and context-dependent. Some of the oncogenic proteins in the cytoplasm a...

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Main Authors: Kexin Li, Qingji Huo, Bai-Yan Li, Hiroki Yokota
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Proteomes
Subjects:
Online Access:https://www.mdpi.com/2227-7382/11/1/5
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author Kexin Li
Qingji Huo
Bai-Yan Li
Hiroki Yokota
author_facet Kexin Li
Qingji Huo
Bai-Yan Li
Hiroki Yokota
author_sort Kexin Li
collection DOAJ
description Unlike a prevalent expectation that tumor cells secrete tumor-promoting proteins and stimulate the progression of neighboring tumor cells, accumulating evidence indicates that the role of tumor-secreted proteins is double-edged and context-dependent. Some of the oncogenic proteins in the cytoplasm and cell membranes, which are considered to promote the proliferation and migration of tumor cells, may inversely act as tumor-suppressing proteins in the extracellular domain. Furthermore, the action of tumor-secreted proteins by aggressive “super-fit” tumor cells can be different from those derived from “less-fit” tumor cells. Tumor cells that are exposed to chemotherapeutic agents could alter their secretory proteomes. Super-fit tumor cells tend to secrete tumor-suppressing proteins, while less-fit or chemotherapeutic agent-treated tumor cells may secrete tumor-promotive proteomes. Interestingly, proteomes derived from nontumor cells such as mesenchymal stem cells and peripheral blood mononuclear cells mostly share common features with tumor cell-derived proteomes in response to certain signals. This review introduces the double-sided functions of tumor-secreted proteins and describes the proposed underlying mechanism, which would possibly be based on cell competition.
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spelling doaj.art-3be1c9cf172e4ce4bc216289ffbba4f62023-11-17T13:33:23ZengMDPI AGProteomes2227-73822023-01-01111510.3390/proteomes11010005The Double-Edged Proteins in Cancer Proteomes and the Generation of Induced Tumor-Suppressing Cells (iTSCs)Kexin Li0Qingji Huo1Bai-Yan Li2Hiroki Yokota3Department of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin 150081, ChinaDepartment of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin 150081, ChinaDepartment of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin 150081, ChinaDepartment of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USAUnlike a prevalent expectation that tumor cells secrete tumor-promoting proteins and stimulate the progression of neighboring tumor cells, accumulating evidence indicates that the role of tumor-secreted proteins is double-edged and context-dependent. Some of the oncogenic proteins in the cytoplasm and cell membranes, which are considered to promote the proliferation and migration of tumor cells, may inversely act as tumor-suppressing proteins in the extracellular domain. Furthermore, the action of tumor-secreted proteins by aggressive “super-fit” tumor cells can be different from those derived from “less-fit” tumor cells. Tumor cells that are exposed to chemotherapeutic agents could alter their secretory proteomes. Super-fit tumor cells tend to secrete tumor-suppressing proteins, while less-fit or chemotherapeutic agent-treated tumor cells may secrete tumor-promotive proteomes. Interestingly, proteomes derived from nontumor cells such as mesenchymal stem cells and peripheral blood mononuclear cells mostly share common features with tumor cell-derived proteomes in response to certain signals. This review introduces the double-sided functions of tumor-secreted proteins and describes the proposed underlying mechanism, which would possibly be based on cell competition.https://www.mdpi.com/2227-7382/11/1/5iTSCsinduced tumor-suppressing cellsproteomesconditioned medium
spellingShingle Kexin Li
Qingji Huo
Bai-Yan Li
Hiroki Yokota
The Double-Edged Proteins in Cancer Proteomes and the Generation of Induced Tumor-Suppressing Cells (iTSCs)
Proteomes
iTSCs
induced tumor-suppressing cells
proteomes
conditioned medium
title The Double-Edged Proteins in Cancer Proteomes and the Generation of Induced Tumor-Suppressing Cells (iTSCs)
title_full The Double-Edged Proteins in Cancer Proteomes and the Generation of Induced Tumor-Suppressing Cells (iTSCs)
title_fullStr The Double-Edged Proteins in Cancer Proteomes and the Generation of Induced Tumor-Suppressing Cells (iTSCs)
title_full_unstemmed The Double-Edged Proteins in Cancer Proteomes and the Generation of Induced Tumor-Suppressing Cells (iTSCs)
title_short The Double-Edged Proteins in Cancer Proteomes and the Generation of Induced Tumor-Suppressing Cells (iTSCs)
title_sort double edged proteins in cancer proteomes and the generation of induced tumor suppressing cells itscs
topic iTSCs
induced tumor-suppressing cells
proteomes
conditioned medium
url https://www.mdpi.com/2227-7382/11/1/5
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