Environmental Stressors and the Unfolded Protein Response (UPR) in Exocrine Pancreatic Function
The exocrine pancreas has the greatest synthetic capacity of any mammalian organ and as such is challenged with synthesis, processing and transporting a large load of digestive enzymes. Here we discuss how both mutations in the digestive enzymes and environmental factors impacting the pancreas such...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-03-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00008/full |
| _version_ | 1819059263294668800 |
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| author | Stephen J Pandol Stephen J Pandol Stephen J Pandol Fred eGorelick Aurelia eLugea Aurelia eLugea |
| author_facet | Stephen J Pandol Stephen J Pandol Stephen J Pandol Fred eGorelick Aurelia eLugea Aurelia eLugea |
| author_sort | Stephen J Pandol |
| collection | DOAJ |
| description | The exocrine pancreas has the greatest synthetic capacity of any mammalian organ and as such is challenged with synthesis, processing and transporting a large load of digestive enzymes. Here we discuss how both mutations in the digestive enzymes and environmental factors impacting the pancreas such as alcohol abuse, smoking, metabolic disorders and drugs can cause Endoplasmic Reticulum (ER) stress. We describe that in normal pancreas the ER stress resulting from alcohol abuse leads to an adaptive Unfolded Protein Response (UPR) allowing for maintenance of protein synthesis, processing and transport. However, when key pathways necessary for the adaptive UPR are altered, the exocrine cell of the pancreas is unable to maintain these processes and cellular pathology results. These findings provide better insights to explain why some individuals with alcohol abuse disorders develop organ injury and disease while most do not. Further, the approach and models described here can be used to determine the relative roles of ER stress and the UPR for other etiologies of pancreatic diseases. |
| first_indexed | 2024-12-21T14:08:19Z |
| format | Article |
| id | doaj.art-3be351cfc95b44d5950c53deb64a4f3a |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-21T14:08:19Z |
| publishDate | 2011-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-3be351cfc95b44d5950c53deb64a4f3a2022-12-21T19:01:08ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2011-03-01210.3389/fphys.2011.000088874Environmental Stressors and the Unfolded Protein Response (UPR) in Exocrine Pancreatic FunctionStephen J Pandol0Stephen J Pandol1Stephen J Pandol2Fred eGorelick3Aurelia eLugea4Aurelia eLugea5Veterans Adminstration Los AngelesUniversity of California, Los AngelesUniversity of Southern California Research Center for ALPD and CirrhosisYale UniversityVeterans Adminstration Los AngelesUniversity of California, Los AngelesThe exocrine pancreas has the greatest synthetic capacity of any mammalian organ and as such is challenged with synthesis, processing and transporting a large load of digestive enzymes. Here we discuss how both mutations in the digestive enzymes and environmental factors impacting the pancreas such as alcohol abuse, smoking, metabolic disorders and drugs can cause Endoplasmic Reticulum (ER) stress. We describe that in normal pancreas the ER stress resulting from alcohol abuse leads to an adaptive Unfolded Protein Response (UPR) allowing for maintenance of protein synthesis, processing and transport. However, when key pathways necessary for the adaptive UPR are altered, the exocrine cell of the pancreas is unable to maintain these processes and cellular pathology results. These findings provide better insights to explain why some individuals with alcohol abuse disorders develop organ injury and disease while most do not. Further, the approach and models described here can be used to determine the relative roles of ER stress and the UPR for other etiologies of pancreatic diseases.http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00008/fullPancreasResearchgastrointestinaluprExocrinePancreatic Function |
| spellingShingle | Stephen J Pandol Stephen J Pandol Stephen J Pandol Fred eGorelick Aurelia eLugea Aurelia eLugea Environmental Stressors and the Unfolded Protein Response (UPR) in Exocrine Pancreatic Function Frontiers in Physiology Pancreas Research gastrointestinal upr Exocrine Pancreatic Function |
| title | Environmental Stressors and the Unfolded Protein Response (UPR) in Exocrine Pancreatic Function |
| title_full | Environmental Stressors and the Unfolded Protein Response (UPR) in Exocrine Pancreatic Function |
| title_fullStr | Environmental Stressors and the Unfolded Protein Response (UPR) in Exocrine Pancreatic Function |
| title_full_unstemmed | Environmental Stressors and the Unfolded Protein Response (UPR) in Exocrine Pancreatic Function |
| title_short | Environmental Stressors and the Unfolded Protein Response (UPR) in Exocrine Pancreatic Function |
| title_sort | environmental stressors and the unfolded protein response upr in exocrine pancreatic function |
| topic | Pancreas Research gastrointestinal upr Exocrine Pancreatic Function |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00008/full |
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