Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory
Summary: Adolescence is a vulnerable period characterized by major cognitive changes. The mechanisms underlying the emergence of new cognitive functions are poorly understood. We find that a long-term depression of inhibitory transmission (iLTD) from parvalbumin-expressing (PV+) interneurons in the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-10-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221112471931232X |
| _version_ | 1828381889882226688 |
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| author | Soledad Domínguez Christophe Clément Rey Ludivine Therreau Aurélien Fanton Dominique Massotte Laure Verret Rebecca Ann Piskorowski Vivien Chevaleyre |
| author_facet | Soledad Domínguez Christophe Clément Rey Ludivine Therreau Aurélien Fanton Dominique Massotte Laure Verret Rebecca Ann Piskorowski Vivien Chevaleyre |
| author_sort | Soledad Domínguez |
| collection | DOAJ |
| description | Summary: Adolescence is a vulnerable period characterized by major cognitive changes. The mechanisms underlying the emergence of new cognitive functions are poorly understood. We find that a long-term depression of inhibitory transmission (iLTD) from parvalbumin-expressing (PV+) interneurons in the hippocampal area Cornu Ammonis 2 (CA2) is absent in young mice but emerges at the end of adolescence. We demonstrate that the maturation of both the perineuronal net (PNN) and signaling through ErbB4 is required for this plasticity. Furthermore, we demonstrate that social recognition memory displays the same age dependence as iLTD and is impaired by targeted degradation of the PNN or iLTD blockade in area CA2. Our data reveal an unusual developmental rule for plasticity at the PV+ interneuron transmission in area CA2 and indicate that this plasticity is involved in the emergence of higher cognitive function, such as social memory formation, in late adolescence. : Dominguez et al. describe the mechanisms involved in the emergence of a form of long-term plasticity at inhibitory synapses from parvalbumin-expressing interneurons in mouse hippocampal area CA2. Maturation of this plasticity potentially underlies the emergence of social memory during late adolescence. Keywords: hippocampus, area CA2, parvalbumin interneuron, social memory, long-term depression, delta opioid receptors, adolescence, ErbB4, neuregulin 1, perineuronal net |
| first_indexed | 2024-12-10T04:22:56Z |
| format | Article |
| id | doaj.art-3be3a5e6434a46c3a2c9d757a0854967 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-10T04:22:56Z |
| publishDate | 2019-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-3be3a5e6434a46c3a2c9d757a08549672022-12-22T02:02:21ZengElsevierCell Reports2211-12472019-10-0129510991112.e4Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social MemorySoledad Domínguez0Christophe Clément Rey1Ludivine Therreau2Aurélien Fanton3Dominique Massotte4Laure Verret5Rebecca Ann Piskorowski6Vivien Chevaleyre7INSERM UMR 1266, Institute of Psychiatry and Neuroscience of Paris, Team Synaptic Plasticity and Neural Networks, 102-108 Rue de la Santé, 75014 Paris, FranceResearch Center on Animal Cognition, Center for Integrative Biology, Toulouse University, CNRS, UPS, Toulouse, FranceINSERM UMR 1266, Institute of Psychiatry and Neuroscience of Paris, Team Synaptic Plasticity and Neural Networks, 102-108 Rue de la Santé, 75014 Paris, France; Inovarion, Centre de Recherche en Sciences du Vivant, 251 Rue St Jacques, 75005 Paris, FranceINSERM UMR 1266, Institute of Psychiatry and Neuroscience of Paris, Team Synaptic Plasticity and Neural Networks, 102-108 Rue de la Santé, 75014 Paris, FranceInstitut des Neurosciences Cellulaires et Intégratives, CNRS UPR 3212, 5 Rue Blaise Pascal, 67084 Strasbourg, FranceResearch Center on Animal Cognition, Center for Integrative Biology, Toulouse University, CNRS, UPS, Toulouse, FranceINSERM UMR 1266, Institute of Psychiatry and Neuroscience of Paris, Team Synaptic Plasticity and Neural Networks, 102-108 Rue de la Santé, 75014 Paris, FranceINSERM UMR 1266, Institute of Psychiatry and Neuroscience of Paris, Team Synaptic Plasticity and Neural Networks, 102-108 Rue de la Santé, 75014 Paris, France; Corresponding authorSummary: Adolescence is a vulnerable period characterized by major cognitive changes. The mechanisms underlying the emergence of new cognitive functions are poorly understood. We find that a long-term depression of inhibitory transmission (iLTD) from parvalbumin-expressing (PV+) interneurons in the hippocampal area Cornu Ammonis 2 (CA2) is absent in young mice but emerges at the end of adolescence. We demonstrate that the maturation of both the perineuronal net (PNN) and signaling through ErbB4 is required for this plasticity. Furthermore, we demonstrate that social recognition memory displays the same age dependence as iLTD and is impaired by targeted degradation of the PNN or iLTD blockade in area CA2. Our data reveal an unusual developmental rule for plasticity at the PV+ interneuron transmission in area CA2 and indicate that this plasticity is involved in the emergence of higher cognitive function, such as social memory formation, in late adolescence. : Dominguez et al. describe the mechanisms involved in the emergence of a form of long-term plasticity at inhibitory synapses from parvalbumin-expressing interneurons in mouse hippocampal area CA2. Maturation of this plasticity potentially underlies the emergence of social memory during late adolescence. Keywords: hippocampus, area CA2, parvalbumin interneuron, social memory, long-term depression, delta opioid receptors, adolescence, ErbB4, neuregulin 1, perineuronal nethttp://www.sciencedirect.com/science/article/pii/S221112471931232X |
| spellingShingle | Soledad Domínguez Christophe Clément Rey Ludivine Therreau Aurélien Fanton Dominique Massotte Laure Verret Rebecca Ann Piskorowski Vivien Chevaleyre Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory Cell Reports |
| title | Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory |
| title_full | Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory |
| title_fullStr | Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory |
| title_full_unstemmed | Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory |
| title_short | Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory |
| title_sort | maturation of pnn and erbb4 signaling in area ca2 during adolescence underlies the emergence of pv interneuron plasticity and social memory |
| url | http://www.sciencedirect.com/science/article/pii/S221112471931232X |
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