Inactivation of a Mismatch-Repair System Diversifies Genotypic Landscape of Escherichia coli During Adaptive Laboratory Evolution

Inactivation of a Mismatch-Repair System Diversifies Genotypic Landscape of Escherichia coli During Adaptive Laboratory Evolution

Adaptive laboratory evolution (ALE) is used to find causal mutations that underlie improved strain performance under the applied selection pressure. ALE studies have revealed that mutator populations tend to outcompete their non-mutator counterparts following the evolutionary trajectory. Among them,...

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Bibliographic Details
Main Authors: Minjeong Kang, Kangsan Kim, Donghui Choe, Suhyung Cho, Sun Chang Kim, Bernhard Palsson, Byung-Kwan Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Microbiology
Subjects:
adaptive laboratory evolution
mismatch repair
Escherichia coli
genotype space
phenotype microarray
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01845/full

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