Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas
Brain tumors account for 20–25% of pediatric cancers. The most frequent type of brain tumor is Glioma from grade I to grade IV according to the rate of malignancy. Current treatments for gliomas use chemotherapy, radiotherapy, tyrosine kinase inhibitors, monoclonal antibodies and surgery, but each o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1222908/full |
| _version_ | 1797751908372316160 |
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| author | Nicola Cecchi Roberta Romanelli Flavia Ricevuti Marianna Amitrano Maria Grazia Carbone Michele Dinardo Ernesto Burgio |
| author_facet | Nicola Cecchi Roberta Romanelli Flavia Ricevuti Marianna Amitrano Maria Grazia Carbone Michele Dinardo Ernesto Burgio |
| author_sort | Nicola Cecchi |
| collection | DOAJ |
| description | Brain tumors account for 20–25% of pediatric cancers. The most frequent type of brain tumor is Glioma from grade I to grade IV according to the rate of malignancy. Current treatments for gliomas use chemotherapy, radiotherapy, tyrosine kinase inhibitors, monoclonal antibodies and surgery, but each of the treatment strategies has several serious side effects. Therefore, to improve treatment efficacy, it is necessary to tailor therapies to patient and tumor characteristics, using appropriate molecular targets. An increasingly popular strategy is pharmaconutrition, which combines a tailored pharmacological treatment with a diet designed to synergize the effects of drugs. In this review we deal in the molecular mechanisms, the epigenetic effects and modulation of the oxidative stress pathway of ketogenic diets, that underlie its possible role, in the treatment of infantile gliomas, as a complementary approach to conventional cancer therapy. |
| first_indexed | 2024-03-12T16:56:35Z |
| format | Article |
| id | doaj.art-3be3f3a15cf8492689be1d9bb0b32733 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-12T16:56:35Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-3be3f3a15cf8492689be1d9bb0b327332023-08-08T05:47:10ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-08-011010.3389/fnut.2023.12229081222908Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomasNicola Cecchi0Roberta Romanelli1Flavia Ricevuti2Marianna Amitrano3Maria Grazia Carbone4Michele Dinardo5Ernesto Burgio6Clinical Nutrition Unit – A.O.R.N. Santobono-Pausilipon Children’s Hospital, Naples, ItalyClinical Nutrition Unit – A.O.R.N. Santobono-Pausilipon Children’s Hospital, Naples, ItalyClinical Nutrition Unit – A.O.R.N. Santobono-Pausilipon Children’s Hospital, Naples, ItalyDepartment of Translational Medical Science, Section of Pediatrics, University of Naples “Federico II”, Naples, ItalyClinical Nutrition Unit – A.O.R.N. Santobono-Pausilipon Children’s Hospital, Naples, ItalyClinical Nutrition Unit – A.O.R.N. Santobono-Pausilipon Children’s Hospital, Naples, ItalyECERI-European Cancer and Environment Research Institute, Brussels, BelgiumBrain tumors account for 20–25% of pediatric cancers. The most frequent type of brain tumor is Glioma from grade I to grade IV according to the rate of malignancy. Current treatments for gliomas use chemotherapy, radiotherapy, tyrosine kinase inhibitors, monoclonal antibodies and surgery, but each of the treatment strategies has several serious side effects. Therefore, to improve treatment efficacy, it is necessary to tailor therapies to patient and tumor characteristics, using appropriate molecular targets. An increasingly popular strategy is pharmaconutrition, which combines a tailored pharmacological treatment with a diet designed to synergize the effects of drugs. In this review we deal in the molecular mechanisms, the epigenetic effects and modulation of the oxidative stress pathway of ketogenic diets, that underlie its possible role, in the treatment of infantile gliomas, as a complementary approach to conventional cancer therapy.https://www.frontiersin.org/articles/10.3389/fnut.2023.1222908/fullbrain cancerketogenic dietpediatricsgliomaepigenetic |
| spellingShingle | Nicola Cecchi Roberta Romanelli Flavia Ricevuti Marianna Amitrano Maria Grazia Carbone Michele Dinardo Ernesto Burgio Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas Frontiers in Nutrition brain cancer ketogenic diet pediatrics glioma epigenetic |
| title | Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas |
| title_full | Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas |
| title_fullStr | Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas |
| title_full_unstemmed | Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas |
| title_short | Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas |
| title_sort | current knowledges in pharmaconutrition ketogenics in pediatric gliomas |
| topic | brain cancer ketogenic diet pediatrics glioma epigenetic |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1222908/full |
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