Nifedipine and losartan effects on endothelial function during acute pharmacological test in arterial hypertension patients with various risk factors
Aim. To study nifedipine and losartan effects on endothelial function (EF) during acute pharmacological test (APT) in arterial hypertension (AH) patients with several risk factors (RF). Material and methods. The study included 94 patients with Stage I AH. All participants were divided into three gro...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2008-02-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1055 |
| Summary: | Aim. To study nifedipine and losartan effects on endothelial function (EF) during acute pharmacological test (APT) in arterial hypertension (AH) patients with several risk factors (RF). Material and methods. The study included 94 patients with Stage I AH. All participants were divided into three groups: Group I – 31 AH patients with obesity (mean body mass index (BMI) 34,7±3,37 kg/m2); Group II – 32 smokers with AH and mean BMI 23,5±2,19 kg/m2; Group III - 31 AH patients with two RF (smoking and obesity) and mean BMI 35,1±3,72 кг/м2. Mean age was 47,9±8,2 years, mean AH duration - 12,4±2,0 years in Group I, 11,0±1,8 years in Group II, and 11,8±1,7 years in Group III. Angiotensin II receptor antagonist losartan was used as a comparison agent. All participants underwent general clinical examination. Endothelium dependent vasodilatation, diameters of common carotid artery and brachial artery, BA (Duplex method), linear blood flow velocities (peak systolic, maximal end diastolic, time averaged maximal velocities), and peripheral resistance index were measured. The participants received nifedipine (20 mg/d) and losartan (100 mg/d) once. Results. Comparative analysis of two medications’ effectiveness demonstrated improved endothelium dependent vasodilatation during APT with nifedipine and losartan. After nifedipine APT, BA diameter significantly increased in Groups I and III, after losartan APT – in Group III. Conclusion. Nifedipine improved EF in AH patients with various RF |
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| ISSN: | 1728-8800 2619-0125 |