Fusarium proliferatum-induced chronic lip ulcer: successful treatment with itraconazole: a case report
Abstract Background Fusarium species are saprophytic fungi with a worldwide distribution. These fungi cause various infections among immunocompromised patients; however, they can also involve immunocompetent individuals. Case presentation We report a case of a 41-year-old Iranian woman who presented...
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| Language: | English |
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BMC
2022-09-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-022-03575-5 |
| _version_ | 1818024668565602304 |
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| author | Fatemeh Mohaghegh Bahareh Abtahi-Naeini Elahe Nasri Parisa Badiee Hamid Morovati Hamed Fakhim Aida Farmani Mohsen Meidani Maryam Ranjbar-Mobarake Rasoul Mohammadi |
| author_facet | Fatemeh Mohaghegh Bahareh Abtahi-Naeini Elahe Nasri Parisa Badiee Hamid Morovati Hamed Fakhim Aida Farmani Mohsen Meidani Maryam Ranjbar-Mobarake Rasoul Mohammadi |
| author_sort | Fatemeh Mohaghegh |
| collection | DOAJ |
| description | Abstract Background Fusarium species are saprophytic fungi with a worldwide distribution. These fungi cause various infections among immunocompromised patients; however, they can also involve immunocompetent individuals. Case presentation We report a case of a 41-year-old Iranian woman who presented with ulcerative lesions on her lips 10 months ago. She had a long history of anxiety but had no history of classical risk factors such as trauma, cosmetic lip tattoo, burning in her lips, smoking or use of alcohol and opium. A skin biopsy from the lower lip was performed and sent for microbiological examinations. Hyaline septate hyphae were seen on direct microscopy with potassium hydroxide. The clinical specimen was subcultured on sabouraud dextrose agar with chloramphenicol and prepared for antifungal susceptibility testing and molecular identification. Considering the minimum inhibitory concentrations (MIC) for antifungals, itraconazole (100 mg orally twice a day) was started for her, and after 2 months, the lesions were treated. She followed up for 3 months, and no signs of disease recurrence were observed. Conclusions Selecting an appropriate treatment strategy according to the laboratory assessments is essential in clinical practice and the management of rare infections to prevent related mortality and morbidity of opportunistic fungal infections. |
| first_indexed | 2024-12-10T04:03:52Z |
| format | Article |
| id | doaj.art-3be9fdef8434493591d880ca1d223f8d |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-10T04:03:52Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-3be9fdef8434493591d880ca1d223f8d2022-12-22T02:02:54ZengBMCJournal of Medical Case Reports1752-19472022-09-011611610.1186/s13256-022-03575-5Fusarium proliferatum-induced chronic lip ulcer: successful treatment with itraconazole: a case reportFatemeh Mohaghegh0Bahareh Abtahi-Naeini1Elahe Nasri2Parisa Badiee3Hamid Morovati4Hamed Fakhim5Aida Farmani6Mohsen Meidani7Maryam Ranjbar-Mobarake8Rasoul Mohammadi9Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, School of Medicine, Isfahan University of Medical SciencesPediatric Dermatology Division of Department of Pediatrics, Imam Hossein Children’s Hospital, Isfahan University of Medical SciencesInfectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical SciencesClinical Microbiology Research Center, Shiraz University of Medical SciencesDepartment of Parasitology and Mycology, School of Medicine, Shiraz University of Medical SciencesInfectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical SciencesDepartment of Dermatology, Isfahan University of Medical SciencesDepartment of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical SciencesDepartment of Microbiology, North branch Islamic Azad UniversityDepartment of Medical Parasitology and Mycology, School of Medicine, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical SciencesAbstract Background Fusarium species are saprophytic fungi with a worldwide distribution. These fungi cause various infections among immunocompromised patients; however, they can also involve immunocompetent individuals. Case presentation We report a case of a 41-year-old Iranian woman who presented with ulcerative lesions on her lips 10 months ago. She had a long history of anxiety but had no history of classical risk factors such as trauma, cosmetic lip tattoo, burning in her lips, smoking or use of alcohol and opium. A skin biopsy from the lower lip was performed and sent for microbiological examinations. Hyaline septate hyphae were seen on direct microscopy with potassium hydroxide. The clinical specimen was subcultured on sabouraud dextrose agar with chloramphenicol and prepared for antifungal susceptibility testing and molecular identification. Considering the minimum inhibitory concentrations (MIC) for antifungals, itraconazole (100 mg orally twice a day) was started for her, and after 2 months, the lesions were treated. She followed up for 3 months, and no signs of disease recurrence were observed. Conclusions Selecting an appropriate treatment strategy according to the laboratory assessments is essential in clinical practice and the management of rare infections to prevent related mortality and morbidity of opportunistic fungal infections.https://doi.org/10.1186/s13256-022-03575-5Fusarium proliferatumItraconazoleImmunocompetentCase report |
| spellingShingle | Fatemeh Mohaghegh Bahareh Abtahi-Naeini Elahe Nasri Parisa Badiee Hamid Morovati Hamed Fakhim Aida Farmani Mohsen Meidani Maryam Ranjbar-Mobarake Rasoul Mohammadi Fusarium proliferatum-induced chronic lip ulcer: successful treatment with itraconazole: a case report Journal of Medical Case Reports Fusarium proliferatum Itraconazole Immunocompetent Case report |
| title | Fusarium proliferatum-induced chronic lip ulcer: successful treatment with itraconazole: a case report |
| title_full | Fusarium proliferatum-induced chronic lip ulcer: successful treatment with itraconazole: a case report |
| title_fullStr | Fusarium proliferatum-induced chronic lip ulcer: successful treatment with itraconazole: a case report |
| title_full_unstemmed | Fusarium proliferatum-induced chronic lip ulcer: successful treatment with itraconazole: a case report |
| title_short | Fusarium proliferatum-induced chronic lip ulcer: successful treatment with itraconazole: a case report |
| title_sort | fusarium proliferatum induced chronic lip ulcer successful treatment with itraconazole a case report |
| topic | Fusarium proliferatum Itraconazole Immunocompetent Case report |
| url | https://doi.org/10.1186/s13256-022-03575-5 |
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