Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Negatively Regulates Innate Immunity Against RNA Virus by Targeting RIG-I in Macrophages

Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Negatively Regulates Innate Immunity Against RNA Virus by Targeting RIG-I in Macrophages

A systematic and flexible immunoregulatory network is required to ensure the proper outcome of antiviral immune signaling and maintain homeostasis during viral infection. Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2), a novel immunoregulatory protein, has been extensively studied in infla...

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Bibliographic Details
Main Authors: Ziqi Zou, Mengyao Li, Yunlian Zhou, Jiaying Li, Ting Pan, Lihua Lai, Qingqing Wang, Lining Zhang, Qun Wang, Yinjing Song, Yuanyuan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
TIPE2
type I interferon
RIG-I
VSV
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.642715/full

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