Advancing Cancer Treatment: Enhanced Combination Therapy through Functionalized Porous Nanoparticles
Cancer remains a major global health challenge, necessitating the development of innovative treatment strategies. This review focuses on the functionalization of porous nanoparticles for combination therapy, a promising approach to enhance cancer treatment efficacy while mitigating the limitations a...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/12/2/326 |
| _version_ | 1797298811381481472 |
|---|---|
| author | Kibeom Kim Myoung-Hwan Park |
| author_facet | Kibeom Kim Myoung-Hwan Park |
| author_sort | Kibeom Kim |
| collection | DOAJ |
| description | Cancer remains a major global health challenge, necessitating the development of innovative treatment strategies. This review focuses on the functionalization of porous nanoparticles for combination therapy, a promising approach to enhance cancer treatment efficacy while mitigating the limitations associated with conventional methods. Combination therapy, integrating multiple treatment modalities such as chemotherapy, phototherapy, immunotherapy, and others, has emerged as an effective strategy to address the shortcomings of individual treatments. The unique properties of mesoporous silica nanoparticles (MSN) and other porous materials, like nanoparticles coated with mesoporous silica (NP@MS), metal–organic frameworks (MOF), mesoporous platinum nanoparticles (mesoPt), and carbon dots (CDs), are being explored for drug solubility, bioavailability, targeted delivery, and controlled drug release. Recent advancements in the functionalization of mesoporous nanoparticles with ligands, biomaterials, and polymers are reviewed here, highlighting their role in enhancing the efficacy of combination therapy. Various research has demonstrated the effectiveness of these nanoparticles in co-delivering drugs and photosensitizers, achieving targeted delivery, and responding to multiple stimuli for controlled drug release. This review introduces the synthesis and functionalization methods of these porous nanoparticles, along with their applications in combination therapy. |
| first_indexed | 2024-03-07T22:41:30Z |
| format | Article |
| id | doaj.art-3bec6c8d4ed54cf8af9914519f0f885a |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-07T22:41:30Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-3bec6c8d4ed54cf8af9914519f0f885a2024-02-23T15:08:29ZengMDPI AGBiomedicines2227-90592024-01-0112232610.3390/biomedicines12020326Advancing Cancer Treatment: Enhanced Combination Therapy through Functionalized Porous NanoparticlesKibeom Kim0Myoung-Hwan Park1Convergence Research Center, Nanobiomaterials Institute, Sahmyook University, Seoul 01795, Republic of KoreaConvergence Research Center, Nanobiomaterials Institute, Sahmyook University, Seoul 01795, Republic of KoreaCancer remains a major global health challenge, necessitating the development of innovative treatment strategies. This review focuses on the functionalization of porous nanoparticles for combination therapy, a promising approach to enhance cancer treatment efficacy while mitigating the limitations associated with conventional methods. Combination therapy, integrating multiple treatment modalities such as chemotherapy, phototherapy, immunotherapy, and others, has emerged as an effective strategy to address the shortcomings of individual treatments. The unique properties of mesoporous silica nanoparticles (MSN) and other porous materials, like nanoparticles coated with mesoporous silica (NP@MS), metal–organic frameworks (MOF), mesoporous platinum nanoparticles (mesoPt), and carbon dots (CDs), are being explored for drug solubility, bioavailability, targeted delivery, and controlled drug release. Recent advancements in the functionalization of mesoporous nanoparticles with ligands, biomaterials, and polymers are reviewed here, highlighting their role in enhancing the efficacy of combination therapy. Various research has demonstrated the effectiveness of these nanoparticles in co-delivering drugs and photosensitizers, achieving targeted delivery, and responding to multiple stimuli for controlled drug release. This review introduces the synthesis and functionalization methods of these porous nanoparticles, along with their applications in combination therapy.https://www.mdpi.com/2227-9059/12/2/326porous nanoparticlecombination therapynanomedicinefunctionalization |
| spellingShingle | Kibeom Kim Myoung-Hwan Park Advancing Cancer Treatment: Enhanced Combination Therapy through Functionalized Porous Nanoparticles Biomedicines porous nanoparticle combination therapy nanomedicine functionalization |
| title | Advancing Cancer Treatment: Enhanced Combination Therapy through Functionalized Porous Nanoparticles |
| title_full | Advancing Cancer Treatment: Enhanced Combination Therapy through Functionalized Porous Nanoparticles |
| title_fullStr | Advancing Cancer Treatment: Enhanced Combination Therapy through Functionalized Porous Nanoparticles |
| title_full_unstemmed | Advancing Cancer Treatment: Enhanced Combination Therapy through Functionalized Porous Nanoparticles |
| title_short | Advancing Cancer Treatment: Enhanced Combination Therapy through Functionalized Porous Nanoparticles |
| title_sort | advancing cancer treatment enhanced combination therapy through functionalized porous nanoparticles |
| topic | porous nanoparticle combination therapy nanomedicine functionalization |
| url | https://www.mdpi.com/2227-9059/12/2/326 |
| work_keys_str_mv | AT kibeomkim advancingcancertreatmentenhancedcombinationtherapythroughfunctionalizedporousnanoparticles AT myounghwanpark advancingcancertreatmentenhancedcombinationtherapythroughfunctionalizedporousnanoparticles |