Molecular motors and nuclear movements in muscle
Muscle fibers have the particularity of containing numerous nuclei evenly distributed and positioned next to the plasma membrane. This unique disposition is the result of sequential events of nuclear movements that start when myoblasts fuse together and end with the clustering of few nuclei under th...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-05-01
|
| Series: | Communicative & Integrative Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19420889.2017.1319537 |
| _version_ | 1818447644266070016 |
|---|---|
| author | E. R. Gomes B. Cadot |
| author_facet | E. R. Gomes B. Cadot |
| author_sort | E. R. Gomes |
| collection | DOAJ |
| description | Muscle fibers have the particularity of containing numerous nuclei evenly distributed and positioned next to the plasma membrane. This unique disposition is the result of sequential events of nuclear movements that start when myoblasts fuse together and end with the clustering of few nuclei under the neuromuscular junction. Nuclei are mispositioned in multiple muscle disorders therefore the mechanisms of nuclear positioning can be novel targets for muscle disorders therapies. The 2 first nuclear movements that occur upon myoblast fusion require different microtubule motors. We performed a siRNA screen against all the microtubules motors and quantified nuclei behavior after fusion and inside the myotube. The different motors we found to be involved in the nuclear behaviors and the analysis of motors expression suggest a competition between both movement mechanisms, which potentially relies on the discrepancy between myoblast and myotube microtubules stability. |
| first_indexed | 2024-12-14T20:06:54Z |
| format | Article |
| id | doaj.art-3bed3a01fab8492da5bb18a50e7613bd |
| institution | Directory Open Access Journal |
| issn | 1942-0889 |
| language | English |
| last_indexed | 2024-12-14T20:06:54Z |
| publishDate | 2017-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Communicative & Integrative Biology |
| spelling | doaj.art-3bed3a01fab8492da5bb18a50e7613bd2022-12-21T22:49:01ZengTaylor & Francis GroupCommunicative & Integrative Biology1942-08892017-05-0110310.1080/19420889.2017.13195371319537Molecular motors and nuclear movements in muscleE. R. Gomes0B. Cadot1Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de LisboaINSERM UPMC UMR974, CNRS FRE3617Muscle fibers have the particularity of containing numerous nuclei evenly distributed and positioned next to the plasma membrane. This unique disposition is the result of sequential events of nuclear movements that start when myoblasts fuse together and end with the clustering of few nuclei under the neuromuscular junction. Nuclei are mispositioned in multiple muscle disorders therefore the mechanisms of nuclear positioning can be novel targets for muscle disorders therapies. The 2 first nuclear movements that occur upon myoblast fusion require different microtubule motors. We performed a siRNA screen against all the microtubules motors and quantified nuclei behavior after fusion and inside the myotube. The different motors we found to be involved in the nuclear behaviors and the analysis of motors expression suggest a competition between both movement mechanisms, which potentially relies on the discrepancy between myoblast and myotube microtubules stability.http://dx.doi.org/10.1080/19420889.2017.1319537cell polaritycytoskeletondifferentiationmicrotubulemolecular motorsmotormusclenuclear movement |
| spellingShingle | E. R. Gomes B. Cadot Molecular motors and nuclear movements in muscle Communicative & Integrative Biology cell polarity cytoskeleton differentiation microtubule molecular motors motor muscle nuclear movement |
| title | Molecular motors and nuclear movements in muscle |
| title_full | Molecular motors and nuclear movements in muscle |
| title_fullStr | Molecular motors and nuclear movements in muscle |
| title_full_unstemmed | Molecular motors and nuclear movements in muscle |
| title_short | Molecular motors and nuclear movements in muscle |
| title_sort | molecular motors and nuclear movements in muscle |
| topic | cell polarity cytoskeleton differentiation microtubule molecular motors motor muscle nuclear movement |
| url | http://dx.doi.org/10.1080/19420889.2017.1319537 |
| work_keys_str_mv | AT ergomes molecularmotorsandnuclearmovementsinmuscle AT bcadot molecularmotorsandnuclearmovementsinmuscle |