FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOL
This study was carried out to develop matrix based transdermal patches containing Atenolol. A 2 factors (HPMC (hydroxyl propyl methyl cellulose) K4M & PVP (Polyvinyl Pyrolidone) 3 level (23) factorial design was done using Design Expert® which gave 13 experiments. The patches were prepared by So...
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2016-10-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1058 |
| _version_ | 1818927454255841280 |
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| author | Uttam Budhathoki Kshitij Gartoulla Shailendra Shakya |
| author_facet | Uttam Budhathoki Kshitij Gartoulla Shailendra Shakya |
| author_sort | Uttam Budhathoki |
| collection | DOAJ |
| description | This study was carried out to develop matrix based transdermal patches containing Atenolol. A 2 factors (HPMC (hydroxyl propyl methyl cellulose) K4M & PVP (Polyvinyl Pyrolidone) 3 level (23) factorial design was done using Design Expert® which gave 13 experiments. The patches were prepared by Solvent casting method. Propylene glycol (3%) and Tween 80 (6%) were used as plasticizer and permeation enhancer respectively. Physicochemical characteristics and In-Vitro permeation study of formulated transdermal patches were carried out. Contour plot suggested 770 mg of PVP and 265 mg of HPMC K4M in Optimized formulation. |
| first_indexed | 2024-12-20T03:13:16Z |
| format | Article |
| id | doaj.art-3bed40bba8384d5b82666b06a501c2dc |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-20T03:13:16Z |
| publishDate | 2016-10-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-3bed40bba8384d5b82666b06a501c2dc2022-12-21T19:55:24ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862016-10-01274196202http://dx.doi.org/10.14499/indonesianjpharm27iss4pp196FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOLUttam Budhathoki0Kshitij Gartoulla1Shailendra Shakya2Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre, Nepal. GPO box 6250 (Kathmandu) Country Nepal.Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre, Nepal. GPO box 6250 (Kathmandu) Country Nepal.Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre, Nepal. GPO box 6250 (Kathmandu) Country Nepal.This study was carried out to develop matrix based transdermal patches containing Atenolol. A 2 factors (HPMC (hydroxyl propyl methyl cellulose) K4M & PVP (Polyvinyl Pyrolidone) 3 level (23) factorial design was done using Design Expert® which gave 13 experiments. The patches were prepared by Solvent casting method. Propylene glycol (3%) and Tween 80 (6%) were used as plasticizer and permeation enhancer respectively. Physicochemical characteristics and In-Vitro permeation study of formulated transdermal patches were carried out. Contour plot suggested 770 mg of PVP and 265 mg of HPMC K4M in Optimized formulation.http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1058AtenololTransdermal PatchesIn-Vitro permeation studypermeation enhancerHPMCPVP |
| spellingShingle | Uttam Budhathoki Kshitij Gartoulla Shailendra Shakya FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOL Indonesian Journal of Pharmacy Atenolol Transdermal Patches In-Vitro permeation study permeation enhancer HPMC PVP |
| title | FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOL |
| title_full | FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOL |
| title_fullStr | FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOL |
| title_full_unstemmed | FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOL |
| title_short | FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOL |
| title_sort | formulation and evaluation of transdermal patches of atenolol |
| topic | Atenolol Transdermal Patches In-Vitro permeation study permeation enhancer HPMC PVP |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1058 |
| work_keys_str_mv | AT uttambudhathoki formulationandevaluationoftransdermalpatchesofatenolol AT kshitijgartoulla formulationandevaluationoftransdermalpatchesofatenolol AT shailendrashakya formulationandevaluationoftransdermalpatchesofatenolol |