S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling

S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling

Alcoholic liver disease (ALD) causes insulin resistance, lipid metabolism dysfunction, and inflammation. We investigated the protective effects and direct regulating target of S-allylmercaptocysteine (SAMC) from aged garlic on liver cell injury. A chronic ethanol-fed ALD in vivo model (the NIAAA mod...

Full description

Bibliographic Details
Main Authors:	Pingping Luo, Ming Zheng, Rui Zhang, Hong Zhang, Yingxia Liu, Wei Li, Xiaoming Sun, Qian Yu, George L. Tipoe, Jia Xiao
Format:	Article
Language:	English
Published:	Elsevier 2021-03-01
Series:	Acta Pharmaceutica Sinica B
Subjects:	Alcoholic liver disease S-Allylmercaptocysteine Insulin receptor Insulin resistance IRS-1 AKT
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383520307978

Similar Items

S-allylmercaptocysteine promotes anti-tumor immunity by suppressing PD-L1 expression
by: Jianxiong Zhao, et al.
Published: (2023-05-01)

Insulin receptor-inspired soluble insulin binder
by: Christopher Mendoza, et al.
Published: (2023-06-01)

Correspondence on Editorial regarding “Screening and prediction of nonalcoholic fatty liver disease using a peripheral insulin resistance index: Potential benefits and limitations”
by: Jun-Hyuk Lee, et al.
Published: (2023-01-01)

Chronic Alcohol Consumption is Inversely Associated with Insulin Resistance and Fatty Liver in Japanese Males
by: Takemi Akahane, et al.
Published: (2020-04-01)

Clinical analysis of insulin resistance in liver cirrhosis patients
by: SHI Cuicui, et al.
Published: (2023-02-01)

The Insulin Receptor Mediates Insulin’s Early Plasma Clearance by Liver, Muscle, and Kidney
by: Rick I. Meijer, et al.
Published: (2021-01-01)

D-Pinitol from <i>Ceratonia siliqua</i> Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats
by: Juan A. Navarro, et al.
Published: (2020-07-01)

Correspondence on Letter regarding “The usefulness of metabolic score for insulin resistance for the prediction of incident non-alcoholic fatty liver disease in Korean adults”
by: Jun-Hyuk Lee, et al.
Published: (2023-01-01)

Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action
by: Vanessa D. de Mello, et al.
Published: (2017-04-01)

The Insulin Receptor Substrate 2 Mediates the Action of Insulin on HeLa Cell Migration via the PI3K/Akt Signaling Pathway
by: Anabel Martínez Báez, et al.
Published: (2023-03-01)

Letter regarding “The usefulness of metabolic score for insulin resistance for the prediction of incident non-alcoholic fatty liver disease in Korean adults”
by: Hye Won Lee
Published: (2023-01-01)

Metabolic Score for Insulin Resistance Is Inversely Related to Incident Advanced Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease
by: Jun-Hyuk Lee, et al.
Published: (2022-07-01)

Arsenic induces the global hypophosphorylation of insulin receptor substrate proteins in differentiated human neuroblastoma SH-SY5Y cells
by: Churaibhon Wisessaowapak, et al.
Published: (2023-03-01)

Neck Circumference as a Predictor of Insulin Resistance in People with Non-alcoholic Fatty Liver Disease
by: Da-Hye Son, et al.
Published: (2023-09-01)

Effects of levothyroxine replacement therapy on insulin resistance in patients with untreated primary hypothyroidism
by: Alireza Ostadrahimi, et al.
Published: (2023-09-01)

The Progression of Liver Fibrosis in Non-alcoholic Fatty Liver Disease
by: Moon Young Kim
Published: (2017-06-01)

Impact of COVID-19 Lockdown on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in Adults: A before and after Pandemic Lockdown Longitudinal Study
by: Ángel Arturo López-González, et al.
Published: (2022-07-01)

Changes of insulin receptors in high fat and high glucose diet mice with insulin resistance
by: Chen Lei, et al.
Published: (2023-12-01)

Phosphorylation Codes in IRS-1 and IRS-2 Are Associated with the Activation/Inhibition of Insulin Canonical Signaling Pathways
by: Anabel Martínez Báez, et al.
Published: (2024-01-01)

Association between remnant cholesterol and insulin resistance levels in patients with metabolic-associated fatty liver disease
by: Shuang Wang, et al.
Published: (2024-02-01)

Machine learning models including insulin resistance indexes for predicting liver stiffness in United States population: Data from NHANES
by: Kexing Han, et al.
Published: (2022-09-01)

Hepatocyte Toll-Like Receptor 4 Mediates Alcohol-Induced Insulin Resistance in Mice
by: Piumi B. Wickramasinghe, et al.
Published: (2023-03-01)

Effects of β-carotene on glucose metabolism dysfunction in humans and type 2 diabetic rats
by: Jianjun Wu, et al.
Published: (2022-04-01)

Targeting Insulin-Degrading Enzyme in Insulin Clearance
by: Malcolm A. Leissring, et al.
Published: (2021-02-01)

Identification of novel mutations of Insulin Receptor Substrate 1 (IRS1) in tumor samples of non-small cell lung cancer (NSCLC): Implications for aberrant insulin signaling in development of cancer
by: Gokhan Gorgisen, et al.
Published: (2019-02-01)

Effects of folic acid supplementation on liver enzymes, lipid profile, and insulin resistance in patients with non-alcoholic fatty liver disease: A randomized controlled trial
by: Mohamad Reza Molaqanbari, et al.
Published: (2023-01-01)

Effect of Exercise on Liver Function and Insulin Resistance Markers in Patients with Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
by: Keyvan Hejazi, et al.
Published: (2023-04-01)

Relationship between Insulin Resistance Risk Scales and Non-Alcoholic Fatty Liver Disease and Liver Fibrosis Scales in 219,477 Spanish Workers
by: José Ignacio Ramírez-Manent, et al.
Published: (2022-11-01)

The role of folate in the management of insulin resistance in adults : a systematic review
by: Theresia Adareth
Published: (2023-09-01)

Sex differences in the association between adipose insulin resistance and non-alcoholic fatty liver disease in Chinese adults
by: Ying Wei, et al.
Published: (2023-10-01)

Associations between serum clusterin levels and non-alcoholic fatty liver disease
by: Yansu Wang, et al.
Published: (2023-06-01)

Clinicopathological characteristics and metabolic profiles of non-alcoholic fatty liver disease in Indian patients with normal body mass index: Do they differ from obese or overweight non-alcoholic fatty liver disease?
by: Ramesh Kumar, et al.
Published: (2013-01-01)

miR-378b Regulates Insulin Sensitivity by Targeting Insulin Receptor and p110α in Alcohol-Induced Hepatic Steatosis
by: Yuan-yuan Li, et al.
Published: (2020-05-01)

Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme
by: Carlos M. González-Casimiro, et al.
Published: (2021-01-01)

Yoga Exercises in Reduce Homa-Ir and Insulin Levels in Polycystic Ovarium Syndrome (PCOS) Insulin Resistant
by: Zakkiyatus Zainiyah, et al.
Published: (2023-10-01)

A Drosophila model of insulin resistance associated with the human TRIB3 Q/R polymorphism
by: Zachary Fischer, et al.
Published: (2017-12-01)

Type 2 Diabetes Mellitus and Liver Disease: Across the Gut–Liver Axis from Fibrosis to Cancer
by: Vittoria Manilla, et al.
Published: (2023-05-01)

NON-ALCOHOLIC FATTY LIVER DISEASE AND SARCOPENIA
by: Pivtorak K. V., et al.
Published: (2022-11-01)

<em>Cyclosorus terminans</em> Extract Ameliorates Insulin Resistance and Non-Alcoholic Fatty Liver Disease (NAFLD) in High-Fat Diet (HFD)-Induced Obese Rats
by: Sujinda Songtrai, et al.
Published: (2022-11-01)

Dietary Protein Intake during Pregnancy Is Not Associated with Offspring Insulin Sensitivity during the First Two Years of Life
by: Brittany R. Allman, et al.
Published: (2020-05-01)