Mannose-coated nanozyme for relief from chemotherapy-induced peripheral neuropathic pain
Summary: Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a progressive and disturbing peripheral neuropathy with currently no effective treatment. Aberrant production of reactive oxygen species (ROS) in macrophages near peripheral nerves plays a dominant role in CIPNP; however, tradition...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223004911 |
| _version_ | 1797856404270219264 |
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| author | Hu Liu Xin Qing Lijun Peng Ding Zhang Wei Dai Zhilai Yang Jiqian Zhang Xuesheng Liu |
| author_facet | Hu Liu Xin Qing Lijun Peng Ding Zhang Wei Dai Zhilai Yang Jiqian Zhang Xuesheng Liu |
| author_sort | Hu Liu |
| collection | DOAJ |
| description | Summary: Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a progressive and disturbing peripheral neuropathy with currently no effective treatment. Aberrant production of reactive oxygen species (ROS) in macrophages near peripheral nerves plays a dominant role in CIPNP; however, traditional ROS scavengers have difficulty maintaining viability to target macrophages in vivo. Mannose-coated superparamagnetic iron oxide nanoparticles (mSPIONs) were synthesized to treat CIPNP. The anti-ROS and anti-inflammatory effects of mSPIONs were assessed in J774A.1 cells and sciatic nerves in a nociception mouse model induced with vincristine (VCR). We found that the mSPIONs significantly reduced ROS levels in vitro and in vivo. Furthermore, mSPIONs administration specifically reduced IL-6 and TNF-α levels in macrophages near the sciatic nerve and relieved VCR-induced peripheral neuropathic pain. Inhibition of the VCR-upregulated HIF1α/NF-κB signaling pathway may be involved in the alleviation of inflammation. These results provide a new approach for relieving CIPNP using a nanozyme. |
| first_indexed | 2024-04-09T20:39:56Z |
| format | Article |
| id | doaj.art-3bef974ca6c74778bd39b5d9c66d485a |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-09T20:39:56Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-3bef974ca6c74778bd39b5d9c66d485a2023-03-30T04:26:56ZengElsevieriScience2589-00422023-04-01264106414Mannose-coated nanozyme for relief from chemotherapy-induced peripheral neuropathic painHu Liu0Xin Qing1Lijun Peng2Ding Zhang3Wei Dai4Zhilai Yang5Jiqian Zhang6Xuesheng Liu7Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui Province 20032, ChinaDepartment of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui Province 20032, ChinaDepartment of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui Province 20032, ChinaDepartment of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui Province 20032, ChinaDepartment of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui Province 20032, ChinaDepartment of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui Province 20032, ChinaDepartment of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui Province 20032, China; Corresponding authorDepartment of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui Province 20032, China; Corresponding authorSummary: Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a progressive and disturbing peripheral neuropathy with currently no effective treatment. Aberrant production of reactive oxygen species (ROS) in macrophages near peripheral nerves plays a dominant role in CIPNP; however, traditional ROS scavengers have difficulty maintaining viability to target macrophages in vivo. Mannose-coated superparamagnetic iron oxide nanoparticles (mSPIONs) were synthesized to treat CIPNP. The anti-ROS and anti-inflammatory effects of mSPIONs were assessed in J774A.1 cells and sciatic nerves in a nociception mouse model induced with vincristine (VCR). We found that the mSPIONs significantly reduced ROS levels in vitro and in vivo. Furthermore, mSPIONs administration specifically reduced IL-6 and TNF-α levels in macrophages near the sciatic nerve and relieved VCR-induced peripheral neuropathic pain. Inhibition of the VCR-upregulated HIF1α/NF-κB signaling pathway may be involved in the alleviation of inflammation. These results provide a new approach for relieving CIPNP using a nanozyme.http://www.sciencedirect.com/science/article/pii/S2589004223004911Molecular physiologyNeuroscienceImmunologyNanotechnology |
| spellingShingle | Hu Liu Xin Qing Lijun Peng Ding Zhang Wei Dai Zhilai Yang Jiqian Zhang Xuesheng Liu Mannose-coated nanozyme for relief from chemotherapy-induced peripheral neuropathic pain iScience Molecular physiology Neuroscience Immunology Nanotechnology |
| title | Mannose-coated nanozyme for relief from chemotherapy-induced peripheral neuropathic pain |
| title_full | Mannose-coated nanozyme for relief from chemotherapy-induced peripheral neuropathic pain |
| title_fullStr | Mannose-coated nanozyme for relief from chemotherapy-induced peripheral neuropathic pain |
| title_full_unstemmed | Mannose-coated nanozyme for relief from chemotherapy-induced peripheral neuropathic pain |
| title_short | Mannose-coated nanozyme for relief from chemotherapy-induced peripheral neuropathic pain |
| title_sort | mannose coated nanozyme for relief from chemotherapy induced peripheral neuropathic pain |
| topic | Molecular physiology Neuroscience Immunology Nanotechnology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223004911 |
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