Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement
Stereospecific [1,3]-rearrangements are rarely reported method to efficiently build complex organic architectures. Here, the authors describe a metal-free intramolecular hydroalkoxylation/[1,3]-rearrangement sequence affording medium-sized lactams with wide scope, also in an asymmetric fashion.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11245-2 |
| _version_ | 1818342160346382336 |
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| author | Bo Zhou Ying-Qi Zhang Kairui Zhang Ming-Yang Yang Yang-Bo Chen You Li Qian Peng Shou-Fei Zhu Qi-Lin Zhou Long-Wu Ye |
| author_facet | Bo Zhou Ying-Qi Zhang Kairui Zhang Ming-Yang Yang Yang-Bo Chen You Li Qian Peng Shou-Fei Zhu Qi-Lin Zhou Long-Wu Ye |
| author_sort | Bo Zhou |
| collection | DOAJ |
| description | Stereospecific [1,3]-rearrangements are rarely reported method to efficiently build complex organic architectures. Here, the authors describe a metal-free intramolecular hydroalkoxylation/[1,3]-rearrangement sequence affording medium-sized lactams with wide scope, also in an asymmetric fashion. |
| first_indexed | 2024-12-13T16:10:16Z |
| format | Article |
| id | doaj.art-3bf0733c651b4490b0ac9ecc1a0a31bc |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:10:16Z |
| publishDate | 2019-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3bf0733c651b4490b0ac9ecc1a0a31bc2022-12-21T23:38:57ZengNature PortfolioNature Communications2041-17232019-07-0110111110.1038/s41467-019-11245-2Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangementBo Zhou0Ying-Qi Zhang1Kairui Zhang2Ming-Yang Yang3Yang-Bo Chen4You Li5Qian Peng6Shou-Fei Zhu7Qi-Lin Zhou8Long-Wu Ye9State Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory of Chemical Biology of Fujian Province, and College of Chemistry and Chemical Engineering, Xiamen UniversityState Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory of Chemical Biology of Fujian Province, and College of Chemistry and Chemical Engineering, Xiamen UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory of Chemical Biology of Fujian Province, and College of Chemistry and Chemical Engineering, Xiamen UniversityState Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory of Chemical Biology of Fujian Province, and College of Chemistry and Chemical Engineering, Xiamen UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory of Chemical Biology of Fujian Province, and College of Chemistry and Chemical Engineering, Xiamen UniversityStereospecific [1,3]-rearrangements are rarely reported method to efficiently build complex organic architectures. Here, the authors describe a metal-free intramolecular hydroalkoxylation/[1,3]-rearrangement sequence affording medium-sized lactams with wide scope, also in an asymmetric fashion.https://doi.org/10.1038/s41467-019-11245-2 |
| spellingShingle | Bo Zhou Ying-Qi Zhang Kairui Zhang Ming-Yang Yang Yang-Bo Chen You Li Qian Peng Shou-Fei Zhu Qi-Lin Zhou Long-Wu Ye Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement Nature Communications |
| title | Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement |
| title_full | Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement |
| title_fullStr | Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement |
| title_full_unstemmed | Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement |
| title_short | Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement |
| title_sort | stereoselective synthesis of medium lactams enabled by metal free hydroalkoxylation stereospecific 1 3 rearrangement |
| url | https://doi.org/10.1038/s41467-019-11245-2 |
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