Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study
Abstract Background Inflammatory markers have been associated with depression and anxiety disorder in adolescents. Less is known about the association between inflammation and subclinical symptoms in the form of psychological distress. We investigated prevalence of psychological distress and examine...
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BMC
2022-03-01
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| Series: | BMC Psychology |
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| Online Access: | https://doi.org/10.1186/s40359-022-00779-8 |
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| author | Jonas Linkas Luai Awad Ahmed Gabor Csifcsak Nina Emaus Anne-Sofie Furberg Guri Grimnes Gunn Pettersen Kamilla Rognmo Tore Christoffersen |
| author_facet | Jonas Linkas Luai Awad Ahmed Gabor Csifcsak Nina Emaus Anne-Sofie Furberg Guri Grimnes Gunn Pettersen Kamilla Rognmo Tore Christoffersen |
| author_sort | Jonas Linkas |
| collection | DOAJ |
| description | Abstract Background Inflammatory markers have been associated with depression and anxiety disorder in adolescents. Less is known about the association between inflammation and subclinical symptoms in the form of psychological distress. We investigated prevalence of psychological distress and examined the associations between common pro-inflammatory markers and psychological distress in an adolescent population sample. Methods The study was based on data from 458 girls and 473 boys aged 15–17 years from the Fit Futures Study, a large-scale study on adolescent health, conducted in Northern Norway. Psychological distress was measured with the Hopkins Symptom Checklist (HSCL-10). Serum-levels of the following low-grade inflammatory markers were measured: C-reactive protein (CRP), interleukin 6 (IL-6), transforming growth factor-alpha (TGF-α), tumor necrosis factor alpha variant 1 (TRANCE) and tumor necrosis factor alpha variant 2 (TWEAK). Associations between quartiles of inflammatory markers and HSCL-10 were examined by logistic regression and adjusted for potential confounders in sex-stratified analyses. Results The proportion of psychological distress above cutoff were 26.9% and 10.8% among girls and boys, respectively. In both girls and boys, crude analysis showed positive associations between all inflammatory markers and HSCL-10, except for TWEAK and TRANCE in boys. However, none of these associations were statistically significant. Further, there were no significant findings in the adjusted analyses. Conclusion There was a higher prevalence of psychological distress in girls compared to boys. Pro-inflammatory markers were not significantly associated with psychological distress in data from healthy adolescents aged 15–17 years. |
| first_indexed | 2024-12-13T09:09:02Z |
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| institution | Directory Open Access Journal |
| issn | 2050-7283 |
| language | English |
| last_indexed | 2024-12-13T09:09:02Z |
| publishDate | 2022-03-01 |
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| series | BMC Psychology |
| spelling | doaj.art-3bf1676714a24ac98d097c3bececf8692022-12-21T23:53:00ZengBMCBMC Psychology2050-72832022-03-0110111310.1186/s40359-022-00779-8Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures studyJonas Linkas0Luai Awad Ahmed1Gabor Csifcsak2Nina Emaus3Anne-Sofie Furberg4Guri Grimnes5Gunn Pettersen6Kamilla Rognmo7Tore Christoffersen8Department of Health and Care Sciences, UiT The Arctic University of NorwayInstitute of Public Health, College of Medicine and Health Sciences, United Arab Emirates UniversityDepartment of Psychology, UiT The Arctic University of NorwayDepartment of Health and Care Sciences, UiT The Arctic University of NorwayFaculty of Health and Care Sciences, Molde University CollegeDivision of Internal Medicine, University Hospital of North NorwayDepartment of Health and Care Sciences, UiT The Arctic University of NorwayDepartment of Psychology, UiT The Arctic University of NorwayDepartment of Health and Care Sciences, UiT The Arctic University of NorwayAbstract Background Inflammatory markers have been associated with depression and anxiety disorder in adolescents. Less is known about the association between inflammation and subclinical symptoms in the form of psychological distress. We investigated prevalence of psychological distress and examined the associations between common pro-inflammatory markers and psychological distress in an adolescent population sample. Methods The study was based on data from 458 girls and 473 boys aged 15–17 years from the Fit Futures Study, a large-scale study on adolescent health, conducted in Northern Norway. Psychological distress was measured with the Hopkins Symptom Checklist (HSCL-10). Serum-levels of the following low-grade inflammatory markers were measured: C-reactive protein (CRP), interleukin 6 (IL-6), transforming growth factor-alpha (TGF-α), tumor necrosis factor alpha variant 1 (TRANCE) and tumor necrosis factor alpha variant 2 (TWEAK). Associations between quartiles of inflammatory markers and HSCL-10 were examined by logistic regression and adjusted for potential confounders in sex-stratified analyses. Results The proportion of psychological distress above cutoff were 26.9% and 10.8% among girls and boys, respectively. In both girls and boys, crude analysis showed positive associations between all inflammatory markers and HSCL-10, except for TWEAK and TRANCE in boys. However, none of these associations were statistically significant. Further, there were no significant findings in the adjusted analyses. Conclusion There was a higher prevalence of psychological distress in girls compared to boys. Pro-inflammatory markers were not significantly associated with psychological distress in data from healthy adolescents aged 15–17 years.https://doi.org/10.1186/s40359-022-00779-8Psychological distressInflammatory markersDepressive symptomsAnxiety symptomsAdolescence |
| spellingShingle | Jonas Linkas Luai Awad Ahmed Gabor Csifcsak Nina Emaus Anne-Sofie Furberg Guri Grimnes Gunn Pettersen Kamilla Rognmo Tore Christoffersen Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study BMC Psychology Psychological distress Inflammatory markers Depressive symptoms Anxiety symptoms Adolescence |
| title | Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study |
| title_full | Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study |
| title_fullStr | Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study |
| title_full_unstemmed | Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study |
| title_short | Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study |
| title_sort | are pro inflammatory markers associated with psychological distress in a cross sectional study of healthy adolescents 15 17 years of age the fit futures study |
| topic | Psychological distress Inflammatory markers Depressive symptoms Anxiety symptoms Adolescence |
| url | https://doi.org/10.1186/s40359-022-00779-8 |
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