Cold-induced hyperphagia requires AgRP neuron activation in mice
To maintain energy homeostasis during cold exposure, the increased energy demands of thermogenesis must be counterbalanced by increased energy intake. To investigate the neurobiological mechanisms underlying this cold-induced hyperphagia, we asked whether agouti-related peptide (AgRP) neurons are ac...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-12-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/58764 |
| _version_ | 1818019405001392128 |
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| author | Jennifer D Deem Chelsea L Faber Christian Pedersen Bao Anh Phan Sarah A Larsen Kayoko Ogimoto Jarrell T Nelson Vincent Damian Megan A Tran Richard D Palmiter Karl J Kaiyala Jarrad M Scarlett Michael R Bruchas Michael W Schwartz Gregory J Morton |
| author_facet | Jennifer D Deem Chelsea L Faber Christian Pedersen Bao Anh Phan Sarah A Larsen Kayoko Ogimoto Jarrell T Nelson Vincent Damian Megan A Tran Richard D Palmiter Karl J Kaiyala Jarrad M Scarlett Michael R Bruchas Michael W Schwartz Gregory J Morton |
| author_sort | Jennifer D Deem |
| collection | DOAJ |
| description | To maintain energy homeostasis during cold exposure, the increased energy demands of thermogenesis must be counterbalanced by increased energy intake. To investigate the neurobiological mechanisms underlying this cold-induced hyperphagia, we asked whether agouti-related peptide (AgRP) neurons are activated when animals are placed in a cold environment and, if so, whether this response is required for the associated hyperphagia. We report that AgRP neuron activation occurs rapidly upon acute cold exposure, as do increases of both energy expenditure and energy intake, suggesting the mere perception of cold is sufficient to engage each of these responses. We further report that silencing of AgRP neurons selectively blocks the effect of cold exposure to increase food intake but has no effect on energy expenditure. Together, these findings establish a physiologically important role for AgRP neurons in the hyperphagic response to cold exposure. |
| first_indexed | 2024-04-14T07:50:41Z |
| format | Article |
| id | doaj.art-3bf1e03edc9c473196f7e1c90cbf2a36 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:50:41Z |
| publishDate | 2020-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-3bf1e03edc9c473196f7e1c90cbf2a362022-12-22T02:05:11ZengeLife Sciences Publications LtdeLife2050-084X2020-12-01910.7554/eLife.58764Cold-induced hyperphagia requires AgRP neuron activation in miceJennifer D Deem0https://orcid.org/0000-0002-8865-5145Chelsea L Faber1https://orcid.org/0000-0002-4812-8164Christian Pedersen2Bao Anh Phan3Sarah A Larsen4Kayoko Ogimoto5Jarrell T Nelson6Vincent Damian7Megan A Tran8Richard D Palmiter9https://orcid.org/0000-0001-6587-0582Karl J Kaiyala10Jarrad M Scarlett11Michael R Bruchas12https://orcid.org/0000-0003-4713-7816Michael W Schwartz13https://orcid.org/0000-0003-1619-0331Gregory J Morton14https://orcid.org/0000-0002-8106-8386UW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United StatesUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United StatesDepartment of Bioengineering, University of Washington, Seattle, United StatesUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United StatesUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United StatesUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United StatesUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United StatesUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United StatesUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United StatesDepartment of Biochemistry, Howard Hughes Medical Institute, University of Washington, Seattle, United StatesDepartment of Oral Health Sciences, School of Dentistry, University of Washington, Seattle, United StatesUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United States; Department of Pediatric Gastroenterology and Hepatology, Seattle Children’s Hospital, Seattle, United StatesDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, United States; Department of Pharmacology, University of Washington, Seattle, United States; Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United StatesUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United StatesUW Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, United StatesTo maintain energy homeostasis during cold exposure, the increased energy demands of thermogenesis must be counterbalanced by increased energy intake. To investigate the neurobiological mechanisms underlying this cold-induced hyperphagia, we asked whether agouti-related peptide (AgRP) neurons are activated when animals are placed in a cold environment and, if so, whether this response is required for the associated hyperphagia. We report that AgRP neuron activation occurs rapidly upon acute cold exposure, as do increases of both energy expenditure and energy intake, suggesting the mere perception of cold is sufficient to engage each of these responses. We further report that silencing of AgRP neurons selectively blocks the effect of cold exposure to increase food intake but has no effect on energy expenditure. Together, these findings establish a physiologically important role for AgRP neurons in the hyperphagic response to cold exposure.https://elifesciences.org/articles/58764agouti-related peptidebody temperaturehyperphagiathermoregulationenergy intakefiber photometry |
| spellingShingle | Jennifer D Deem Chelsea L Faber Christian Pedersen Bao Anh Phan Sarah A Larsen Kayoko Ogimoto Jarrell T Nelson Vincent Damian Megan A Tran Richard D Palmiter Karl J Kaiyala Jarrad M Scarlett Michael R Bruchas Michael W Schwartz Gregory J Morton Cold-induced hyperphagia requires AgRP neuron activation in mice eLife agouti-related peptide body temperature hyperphagia thermoregulation energy intake fiber photometry |
| title | Cold-induced hyperphagia requires AgRP neuron activation in mice |
| title_full | Cold-induced hyperphagia requires AgRP neuron activation in mice |
| title_fullStr | Cold-induced hyperphagia requires AgRP neuron activation in mice |
| title_full_unstemmed | Cold-induced hyperphagia requires AgRP neuron activation in mice |
| title_short | Cold-induced hyperphagia requires AgRP neuron activation in mice |
| title_sort | cold induced hyperphagia requires agrp neuron activation in mice |
| topic | agouti-related peptide body temperature hyperphagia thermoregulation energy intake fiber photometry |
| url | https://elifesciences.org/articles/58764 |
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