Clinical Applications of Cancer-Associated Cells Present in the Blood of Cancer Patients
The ability to obtain tumor material from cells in the blood of cancer patients provides a significant benefit over the use of tumor tissue as a diagnostic to make treatment decisions. However, the traditionally defined circulating tumor cell (CTC) has been shown to be useful only in some cases. A r...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/3/587 |
| _version_ | 1797472751045312512 |
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| author | Cha-Mei Tang Daniel L. Adams |
| author_facet | Cha-Mei Tang Daniel L. Adams |
| author_sort | Cha-Mei Tang |
| collection | DOAJ |
| description | The ability to obtain tumor material from cells in the blood of cancer patients provides a significant benefit over the use of tumor tissue as a diagnostic to make treatment decisions. However, the traditionally defined circulating tumor cell (CTC) has been shown to be useful only in some cases. A recently identified type of circulating stromal cell, which appears to be more frequent than CTCs, was found engulfing tumor material at the tumor site and then entering the blood stream. These cells were defined as cancer-associated macrophage-like cells (CAMLs). Together, CTCs and CAMLs may be able to provide information for cancer detection and diagnosis, without the use of tissue. CTCs and CAMLs have many clinical applications, three of which are summarized in this review: for prognosis, as companion diagnostics, and for residual disease monitoring. |
| first_indexed | 2024-03-09T20:05:40Z |
| format | Article |
| id | doaj.art-3bf1ff71057c4a17996b2fb6d6a7eca7 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:05:40Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-3bf1ff71057c4a17996b2fb6d6a7eca72023-11-24T00:32:25ZengMDPI AGBiomedicines2227-90592022-03-0110358710.3390/biomedicines10030587Clinical Applications of Cancer-Associated Cells Present in the Blood of Cancer PatientsCha-Mei Tang0Daniel L. Adams1Creatv MicroTech, Inc., 9900 Belward Campus Drive, Suite 330, Rockville, MD 20850, USACreatv MicroTech, Inc., 9 Deer Park Drive, Suite M5, Middlesex County, NJ 08852, USAThe ability to obtain tumor material from cells in the blood of cancer patients provides a significant benefit over the use of tumor tissue as a diagnostic to make treatment decisions. However, the traditionally defined circulating tumor cell (CTC) has been shown to be useful only in some cases. A recently identified type of circulating stromal cell, which appears to be more frequent than CTCs, was found engulfing tumor material at the tumor site and then entering the blood stream. These cells were defined as cancer-associated macrophage-like cells (CAMLs). Together, CTCs and CAMLs may be able to provide information for cancer detection and diagnosis, without the use of tissue. CTCs and CAMLs have many clinical applications, three of which are summarized in this review: for prognosis, as companion diagnostics, and for residual disease monitoring.https://www.mdpi.com/2227-9059/10/3/587cancer-associated macrophage-like cells CAMLsCTCscirculating tumor cellsimmunotherapyPD-L1residual disease |
| spellingShingle | Cha-Mei Tang Daniel L. Adams Clinical Applications of Cancer-Associated Cells Present in the Blood of Cancer Patients Biomedicines cancer-associated macrophage-like cells CAMLs CTCs circulating tumor cells immunotherapy PD-L1 residual disease |
| title | Clinical Applications of Cancer-Associated Cells Present in the Blood of Cancer Patients |
| title_full | Clinical Applications of Cancer-Associated Cells Present in the Blood of Cancer Patients |
| title_fullStr | Clinical Applications of Cancer-Associated Cells Present in the Blood of Cancer Patients |
| title_full_unstemmed | Clinical Applications of Cancer-Associated Cells Present in the Blood of Cancer Patients |
| title_short | Clinical Applications of Cancer-Associated Cells Present in the Blood of Cancer Patients |
| title_sort | clinical applications of cancer associated cells present in the blood of cancer patients |
| topic | cancer-associated macrophage-like cells CAMLs CTCs circulating tumor cells immunotherapy PD-L1 residual disease |
| url | https://www.mdpi.com/2227-9059/10/3/587 |
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