Maintaining Weight Loss in Obese Men with Prostate Cancer Following a Supervised Exercise and Nutrition Program—A Pilot Study
Supervised exercise and nutrition programs can mitigate or reverse androgen deprivation therapy (ADT) induced fat mass (FM) gain, lean mass (LM) loss, and impaired physical function. It is unclear whether these benefits are retained following transition to self-management. This study examined the ef...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/14/3411 |
| _version_ | 1797527516816080896 |
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| author | Rebekah L. Wilson Dennis R. Taaffe Robert U. Newton Nicolas H. Hart Philippa Lyons-Wall Daniel A. Galvão |
| author_facet | Rebekah L. Wilson Dennis R. Taaffe Robert U. Newton Nicolas H. Hart Philippa Lyons-Wall Daniel A. Galvão |
| author_sort | Rebekah L. Wilson |
| collection | DOAJ |
| description | Supervised exercise and nutrition programs can mitigate or reverse androgen deprivation therapy (ADT) induced fat mass (FM) gain, lean mass (LM) loss, and impaired physical function. It is unclear whether these benefits are retained following transition to self-management. This study examined the effect of a home-based weight maintenance program on body composition and physical function in obese men with prostate cancer (PCa) on ADT following a 12-week supervised weight loss intervention. Eleven obese PCa patients (74 ± 5 years, 40.0 ± 4.9% body fat) on ADT (>6 months) completed a 12-week self-managed home-based weight maintenance program consisting of 150 min/week of aerobic and resistance training while maintaining a healthy balanced diet. Body composition (DXA), muscle strength (1RM), and cardiorespiratory fitness (400 m walk) were assessed. Significant reductions in weight (−2.8 ± 3.2 kg) and FM (−2.8 ± 2.6 kg), preservation of LM (−0.05 ± 1.6 kg), and improvements in muscle strength and VO<sub>2max</sub> were achieved across the supervised intervention. Across the home-based program, no significant changes were observed in weight (−0.6 ± 2.8 kg, <i>p</i> = 0.508), FM (0.2 ± 1.4 kg, <i>p</i> = 0.619), LM (−0.8 ± 1.6 kg, <i>p</i> = 0.146), muscle strength (−0.2 to 4.1%, <i>p</i> = 0.086–0.745), or estimated VO<sub>2max</sub> (0.3 ± 2.1 mL/min/kg, <i>p</i> = 0.649). Self-managed, home-based exercise and nutrition programs are a viable strategy to promote maintenance of body composition and physical function following a supervised intervention in obese PCa patients on ADT. |
| first_indexed | 2024-03-10T09:43:52Z |
| format | Article |
| id | doaj.art-3bf31a0d89344699a43726670f4723e7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:43:52Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3bf31a0d89344699a43726670f4723e72023-11-22T03:22:43ZengMDPI AGCancers2072-66942021-07-011314341110.3390/cancers13143411Maintaining Weight Loss in Obese Men with Prostate Cancer Following a Supervised Exercise and Nutrition Program—A Pilot StudyRebekah L. Wilson0Dennis R. Taaffe1Robert U. Newton2Nicolas H. Hart3Philippa Lyons-Wall4Daniel A. Galvão5Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USAExercise Medicine Research Institute, Edith Cowan University, Perth, WA 6027, AustraliaExercise Medicine Research Institute, Edith Cowan University, Perth, WA 6027, AustraliaExercise Medicine Research Institute, Edith Cowan University, Perth, WA 6027, AustraliaExercise Medicine Research Institute, Edith Cowan University, Perth, WA 6027, AustraliaExercise Medicine Research Institute, Edith Cowan University, Perth, WA 6027, AustraliaSupervised exercise and nutrition programs can mitigate or reverse androgen deprivation therapy (ADT) induced fat mass (FM) gain, lean mass (LM) loss, and impaired physical function. It is unclear whether these benefits are retained following transition to self-management. This study examined the effect of a home-based weight maintenance program on body composition and physical function in obese men with prostate cancer (PCa) on ADT following a 12-week supervised weight loss intervention. Eleven obese PCa patients (74 ± 5 years, 40.0 ± 4.9% body fat) on ADT (>6 months) completed a 12-week self-managed home-based weight maintenance program consisting of 150 min/week of aerobic and resistance training while maintaining a healthy balanced diet. Body composition (DXA), muscle strength (1RM), and cardiorespiratory fitness (400 m walk) were assessed. Significant reductions in weight (−2.8 ± 3.2 kg) and FM (−2.8 ± 2.6 kg), preservation of LM (−0.05 ± 1.6 kg), and improvements in muscle strength and VO<sub>2max</sub> were achieved across the supervised intervention. Across the home-based program, no significant changes were observed in weight (−0.6 ± 2.8 kg, <i>p</i> = 0.508), FM (0.2 ± 1.4 kg, <i>p</i> = 0.619), LM (−0.8 ± 1.6 kg, <i>p</i> = 0.146), muscle strength (−0.2 to 4.1%, <i>p</i> = 0.086–0.745), or estimated VO<sub>2max</sub> (0.3 ± 2.1 mL/min/kg, <i>p</i> = 0.649). Self-managed, home-based exercise and nutrition programs are a viable strategy to promote maintenance of body composition and physical function following a supervised intervention in obese PCa patients on ADT.https://www.mdpi.com/2072-6694/13/14/3411nutritionexercisebody compositionphysical functionandrogen deprivation therapyhome-based |
| spellingShingle | Rebekah L. Wilson Dennis R. Taaffe Robert U. Newton Nicolas H. Hart Philippa Lyons-Wall Daniel A. Galvão Maintaining Weight Loss in Obese Men with Prostate Cancer Following a Supervised Exercise and Nutrition Program—A Pilot Study Cancers nutrition exercise body composition physical function androgen deprivation therapy home-based |
| title | Maintaining Weight Loss in Obese Men with Prostate Cancer Following a Supervised Exercise and Nutrition Program—A Pilot Study |
| title_full | Maintaining Weight Loss in Obese Men with Prostate Cancer Following a Supervised Exercise and Nutrition Program—A Pilot Study |
| title_fullStr | Maintaining Weight Loss in Obese Men with Prostate Cancer Following a Supervised Exercise and Nutrition Program—A Pilot Study |
| title_full_unstemmed | Maintaining Weight Loss in Obese Men with Prostate Cancer Following a Supervised Exercise and Nutrition Program—A Pilot Study |
| title_short | Maintaining Weight Loss in Obese Men with Prostate Cancer Following a Supervised Exercise and Nutrition Program—A Pilot Study |
| title_sort | maintaining weight loss in obese men with prostate cancer following a supervised exercise and nutrition program a pilot study |
| topic | nutrition exercise body composition physical function androgen deprivation therapy home-based |
| url | https://www.mdpi.com/2072-6694/13/14/3411 |
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