Impact of Breast Cancer and Germline BRCA Pathogenic Variants on Fertility Preservation in Young Women
Background: Several studies have suggested that breast cancer (BC) and germline BRCA pathogenic variants (gBRCA PVs) could have a deleterious impact on ovarian reserve. Nevertheless, data are limited and mixed. Our objective was to evaluate the performance of fertility preservation (FP) in terms of...
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MDPI AG
2023-04-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/4/930 |
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| author | Elze Prokurotaite Margherita Condorelli Julie Dechene Jason Bouziotis Matteo Lambertini Isabelle Demeestere |
| author_facet | Elze Prokurotaite Margherita Condorelli Julie Dechene Jason Bouziotis Matteo Lambertini Isabelle Demeestere |
| author_sort | Elze Prokurotaite |
| collection | DOAJ |
| description | Background: Several studies have suggested that breast cancer (BC) and germline BRCA pathogenic variants (gBRCA PVs) could have a deleterious impact on ovarian reserve. Nevertheless, data are limited and mixed. Our objective was to evaluate the performance of fertility preservation (FP) in terms of the number of collected mature oocytes after ovarian stimulation (OS) in young women carrying a gBRCA PV, associated or not with BC. Methods: We conducted a retrospective monocentric study at HUB-Hôpital Erasme in Brussels. All women aged between 18 and 41 years diagnosed with invasive non-metastatic BC and/or gBRCA PV carriers who underwent OS for FP or preimplantation genetic testing for monogenic disorder (PGT-M) between November 2012 and October 2021 were included. Three groups were compared: BC patients without a gBRCA PV, BC patients with a gBRCA PV, and healthy gBRCA PV carriers. Ovarian reserve was evaluated based on the efficacy of OS and AMH levels. Results: A total of 85 patients underwent 100 cycles. The mean age (32.2 ± 3.9 years; <i>p</i> = 0.61) and median AMH level (1.9 [0.2–13] μg/L; <i>p</i> = 0.22) were similar between groups. Correlations between the number of mature oocytes and AMH level (<i>p</i> < 0.001) and between AMH and age (<i>p</i> < 0.001) were observed. No differences in the number of retrieved mature oocytes were observed between groups (<i>p</i> = 0.41), or for other OS parameters. Conclusion: Neither BC nor a gBRCA PV significantly affects ovarian reserve and FP efficacy in terms of the number of mature oocytes retrieved. |
| first_indexed | 2024-03-11T04:49:51Z |
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| language | English |
| last_indexed | 2024-03-11T04:49:51Z |
| publishDate | 2023-04-01 |
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| series | Life |
| spelling | doaj.art-3bf4191a8add4d24bdf394c76d9094c62023-11-17T20:05:37ZengMDPI AGLife2075-17292023-04-0113493010.3390/life13040930Impact of Breast Cancer and Germline BRCA Pathogenic Variants on Fertility Preservation in Young WomenElze Prokurotaite0Margherita Condorelli1Julie Dechene2Jason Bouziotis3Matteo Lambertini4Isabelle Demeestere5Fertility Clinic, Department of Obstetrics and Gynecology, H.U.B—Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, BelgiumFertility Clinic, Department of Obstetrics and Gynecology, H.U.B—Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, BelgiumResearch Laboratory on Human Reproduction, Université Libre de Bruxelles, 1070 Brussels, BelgiumDepartment of Biomedical Research, H.U.B—Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, BelgiumDepartment of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, 16132 Genova, ItalyFertility Clinic, Department of Obstetrics and Gynecology, H.U.B—Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, BelgiumBackground: Several studies have suggested that breast cancer (BC) and germline BRCA pathogenic variants (gBRCA PVs) could have a deleterious impact on ovarian reserve. Nevertheless, data are limited and mixed. Our objective was to evaluate the performance of fertility preservation (FP) in terms of the number of collected mature oocytes after ovarian stimulation (OS) in young women carrying a gBRCA PV, associated or not with BC. Methods: We conducted a retrospective monocentric study at HUB-Hôpital Erasme in Brussels. All women aged between 18 and 41 years diagnosed with invasive non-metastatic BC and/or gBRCA PV carriers who underwent OS for FP or preimplantation genetic testing for monogenic disorder (PGT-M) between November 2012 and October 2021 were included. Three groups were compared: BC patients without a gBRCA PV, BC patients with a gBRCA PV, and healthy gBRCA PV carriers. Ovarian reserve was evaluated based on the efficacy of OS and AMH levels. Results: A total of 85 patients underwent 100 cycles. The mean age (32.2 ± 3.9 years; <i>p</i> = 0.61) and median AMH level (1.9 [0.2–13] μg/L; <i>p</i> = 0.22) were similar between groups. Correlations between the number of mature oocytes and AMH level (<i>p</i> < 0.001) and between AMH and age (<i>p</i> < 0.001) were observed. No differences in the number of retrieved mature oocytes were observed between groups (<i>p</i> = 0.41), or for other OS parameters. Conclusion: Neither BC nor a gBRCA PV significantly affects ovarian reserve and FP efficacy in terms of the number of mature oocytes retrieved.https://www.mdpi.com/2075-1729/13/4/930fertility preservationoocyte cryopreservationovarian reserveBRCA mutationgermline BRCA pathogenic variantsbreast cancer |
| spellingShingle | Elze Prokurotaite Margherita Condorelli Julie Dechene Jason Bouziotis Matteo Lambertini Isabelle Demeestere Impact of Breast Cancer and Germline BRCA Pathogenic Variants on Fertility Preservation in Young Women Life fertility preservation oocyte cryopreservation ovarian reserve BRCA mutation germline BRCA pathogenic variants breast cancer |
| title | Impact of Breast Cancer and Germline BRCA Pathogenic Variants on Fertility Preservation in Young Women |
| title_full | Impact of Breast Cancer and Germline BRCA Pathogenic Variants on Fertility Preservation in Young Women |
| title_fullStr | Impact of Breast Cancer and Germline BRCA Pathogenic Variants on Fertility Preservation in Young Women |
| title_full_unstemmed | Impact of Breast Cancer and Germline BRCA Pathogenic Variants on Fertility Preservation in Young Women |
| title_short | Impact of Breast Cancer and Germline BRCA Pathogenic Variants on Fertility Preservation in Young Women |
| title_sort | impact of breast cancer and germline brca pathogenic variants on fertility preservation in young women |
| topic | fertility preservation oocyte cryopreservation ovarian reserve BRCA mutation germline BRCA pathogenic variants breast cancer |
| url | https://www.mdpi.com/2075-1729/13/4/930 |
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