The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study
<p>Abstract</p> <p>Background</p> <p>To study the relationship between the intima-media thickness (IMT) of the carotid artery and the stage of chronic kidney disease (CKD) based on the estimated glomerular filtration rate (eGFR) and diabetic nephropathy graded by the ur...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-05-01
|
| Series: | Cardiovascular Diabetology |
| Online Access: | http://www.cardiab.com/content/9/1/18 |
| _version_ | 1811299270057263104 |
|---|---|
| author | Ishida Hidenori Antoku Shinichi Mifune Mizuo Komatsu Yuko Ito Hiroyuki Takeuchi Yuichiro Togane Michiko |
| author_facet | Ishida Hidenori Antoku Shinichi Mifune Mizuo Komatsu Yuko Ito Hiroyuki Takeuchi Yuichiro Togane Michiko |
| author_sort | Ishida Hidenori |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>To study the relationship between the intima-media thickness (IMT) of the carotid artery and the stage of chronic kidney disease (CKD) based on the estimated glomerular filtration rate (eGFR) and diabetic nephropathy graded by the urinary albumin excretion (UAE) in the patients with type 2 diabetes mellitus.</p> <p>Methods</p> <p>A cross-sectional study was performed in 338 patients with type 2 diabetes mellitus. The carotid IMT was measured using an ultrasonographic examination.</p> <p>Results</p> <p>The mean carotid IMT was 1.06 ± 0.27 mm, and 42% of the subjects showed IMT thickening (≥ 1.1 mm). Cerebrovascular disease and coronary heart disease were frequent in the patients with IMT thickening. The carotid IMT elevated significantly with the stage progression of CKD (0.87 ± 0.19 mm in stage 1, 1.02 ± 0.26 mm in stage 2, 1.11 ± 0.26 mm in stage 3, and 1.11 ± 0.27 mm in stage 4+5). However, the IMT was not significantly different among the various stages of diabetic nephropathy. The IMT was significantly greater in the diabetic patients with hypertension compared to those without hypertension. The IMT positively correlated with the age, the duration of diabetes mellitus, and the brachial-ankle pulse wave velocities (baPWV), and negatively correlated with the eGFR. In a stepwise multivariate regression analysis, the eGFR and the baPWV were independently associated with the carotid IMT.</p> <p>Conclusions</p> <p>Our study is the first report showing a relationship between the carotid IMT and the renal parameters including eGFR and the stages of diabetic nephropathy with a confirmed association between the IMT and diabetic macroangiopathy. Our study further confirms the importance of intensive examinations for the early detection of atherosclerosis and positive treatments for hypertension, dyslipidaemia, obesity, as well as hyperglycaemia are necessary when a reduced eGFR is found in diabetic patients.</p> |
| first_indexed | 2024-04-13T06:33:32Z |
| format | Article |
| id | doaj.art-3bf640654cb844a4a6b3899474cce710 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-04-13T06:33:32Z |
| publishDate | 2010-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-3bf640654cb844a4a6b3899474cce7102022-12-22T02:58:01ZengBMCCardiovascular Diabetology1475-28402010-05-01911810.1186/1475-2840-9-18The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional studyIshida HidenoriAntoku ShinichiMifune MizuoKomatsu YukoIto HiroyukiTakeuchi YuichiroTogane Michiko<p>Abstract</p> <p>Background</p> <p>To study the relationship between the intima-media thickness (IMT) of the carotid artery and the stage of chronic kidney disease (CKD) based on the estimated glomerular filtration rate (eGFR) and diabetic nephropathy graded by the urinary albumin excretion (UAE) in the patients with type 2 diabetes mellitus.</p> <p>Methods</p> <p>A cross-sectional study was performed in 338 patients with type 2 diabetes mellitus. The carotid IMT was measured using an ultrasonographic examination.</p> <p>Results</p> <p>The mean carotid IMT was 1.06 ± 0.27 mm, and 42% of the subjects showed IMT thickening (≥ 1.1 mm). Cerebrovascular disease and coronary heart disease were frequent in the patients with IMT thickening. The carotid IMT elevated significantly with the stage progression of CKD (0.87 ± 0.19 mm in stage 1, 1.02 ± 0.26 mm in stage 2, 1.11 ± 0.26 mm in stage 3, and 1.11 ± 0.27 mm in stage 4+5). However, the IMT was not significantly different among the various stages of diabetic nephropathy. The IMT was significantly greater in the diabetic patients with hypertension compared to those without hypertension. The IMT positively correlated with the age, the duration of diabetes mellitus, and the brachial-ankle pulse wave velocities (baPWV), and negatively correlated with the eGFR. In a stepwise multivariate regression analysis, the eGFR and the baPWV were independently associated with the carotid IMT.</p> <p>Conclusions</p> <p>Our study is the first report showing a relationship between the carotid IMT and the renal parameters including eGFR and the stages of diabetic nephropathy with a confirmed association between the IMT and diabetic macroangiopathy. Our study further confirms the importance of intensive examinations for the early detection of atherosclerosis and positive treatments for hypertension, dyslipidaemia, obesity, as well as hyperglycaemia are necessary when a reduced eGFR is found in diabetic patients.</p>http://www.cardiab.com/content/9/1/18 |
| spellingShingle | Ishida Hidenori Antoku Shinichi Mifune Mizuo Komatsu Yuko Ito Hiroyuki Takeuchi Yuichiro Togane Michiko The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study Cardiovascular Diabetology |
| title | The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study |
| title_full | The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study |
| title_fullStr | The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study |
| title_full_unstemmed | The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study |
| title_short | The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study |
| title_sort | estimated gfr but not the stage of diabetic nephropathy graded by the urinary albumin excretion is associated with the carotid intima media thickness in patients with type 2 diabetes mellitus a cross sectional study |
| url | http://www.cardiab.com/content/9/1/18 |
| work_keys_str_mv | AT ishidahidenori theestimatedgfrbutnotthestageofdiabeticnephropathygradedbytheurinaryalbuminexcretionisassociatedwiththecarotidintimamediathicknessinpatientswithtype2diabetesmellitusacrosssectionalstudy AT antokushinichi theestimatedgfrbutnotthestageofdiabeticnephropathygradedbytheurinaryalbuminexcretionisassociatedwiththecarotidintimamediathicknessinpatientswithtype2diabetesmellitusacrosssectionalstudy AT mifunemizuo theestimatedgfrbutnotthestageofdiabeticnephropathygradedbytheurinaryalbuminexcretionisassociatedwiththecarotidintimamediathicknessinpatientswithtype2diabetesmellitusacrosssectionalstudy AT komatsuyuko theestimatedgfrbutnotthestageofdiabeticnephropathygradedbytheurinaryalbuminexcretionisassociatedwiththecarotidintimamediathicknessinpatientswithtype2diabetesmellitusacrosssectionalstudy AT itohiroyuki theestimatedgfrbutnotthestageofdiabeticnephropathygradedbytheurinaryalbuminexcretionisassociatedwiththecarotidintimamediathicknessinpatientswithtype2diabetesmellitusacrosssectionalstudy AT takeuchiyuichiro theestimatedgfrbutnotthestageofdiabeticnephropathygradedbytheurinaryalbuminexcretionisassociatedwiththecarotidintimamediathicknessinpatientswithtype2diabetesmellitusacrosssectionalstudy AT toganemichiko theestimatedgfrbutnotthestageofdiabeticnephropathygradedbytheurinaryalbuminexcretionisassociatedwiththecarotidintimamediathicknessinpatientswithtype2diabetesmellitusacrosssectionalstudy AT ishidahidenori estimatedgfrbutnotthestageofdiabeticnephropathygradedbytheurinaryalbuminexcretionisassociatedwiththecarotidintimamediathicknessinpatientswithtype2diabetesmellitusacrosssectionalstudy AT antokushinichi estimatedgfrbutnotthestageofdiabeticnephropathygradedbytheurinaryalbuminexcretionisassociatedwiththecarotidintimamediathicknessinpatientswithtype2diabetesmellitusacrosssectionalstudy AT mifunemizuo estimatedgfrbutnotthestageofdiabeticnephropathygradedbytheurinaryalbuminexcretionisassociatedwiththecarotidintimamediathicknessinpatientswithtype2diabetesmellitusacrosssectionalstudy AT komatsuyuko estimatedgfrbutnotthestageofdiabeticnephropathygradedbytheurinaryalbuminexcretionisassociatedwiththecarotidintimamediathicknessinpatientswithtype2diabetesmellitusacrosssectionalstudy AT itohiroyuki estimatedgfrbutnotthestageofdiabeticnephropathygradedbytheurinaryalbuminexcretionisassociatedwiththecarotidintimamediathicknessinpatientswithtype2diabetesmellitusacrosssectionalstudy AT takeuchiyuichiro estimatedgfrbutnotthestageofdiabeticnephropathygradedbytheurinaryalbuminexcretionisassociatedwiththecarotidintimamediathicknessinpatientswithtype2diabetesmellitusacrosssectionalstudy AT toganemichiko estimatedgfrbutnotthestageofdiabeticnephropathygradedbytheurinaryalbuminexcretionisassociatedwiththecarotidintimamediathicknessinpatientswithtype2diabetesmellitusacrosssectionalstudy |