The Tripartite Nexus: Autophagy, Cancer, and Tripartite Motif-Containing Protein Family Members
Autophagy is a cellular degradative process that has multiple important actions in cancer. Autophagy modulation is under consideration as a promising new approach to cancer therapy. However, complete autophagy dysregulation is likely to have substantial undesirable side effects. Thus, more targeted...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.00308/full |
| _version_ | 1828342493542875136 |
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| author | Michael A. Mandell Michael A. Mandell Bhaskar Saha Todd A. Thompson Todd A. Thompson |
| author_facet | Michael A. Mandell Michael A. Mandell Bhaskar Saha Todd A. Thompson Todd A. Thompson |
| author_sort | Michael A. Mandell |
| collection | DOAJ |
| description | Autophagy is a cellular degradative process that has multiple important actions in cancer. Autophagy modulation is under consideration as a promising new approach to cancer therapy. However, complete autophagy dysregulation is likely to have substantial undesirable side effects. Thus, more targeted approaches to autophagy modulation may prove clinically beneficial. One potential avenue to achieving this goal is to focus on the actions of tripartite motif-containing protein family members (TRIMs). TRIMs have key roles in an array of cellular processes, and their dysregulation has been extensively linked to cancer risk and prognosis. As detailed here, emerging data shows that TRIMs can play important yet context-dependent roles in controlling autophagy and in the selective targeting of autophagic substrates. This review covers how the autophagy-related actions of TRIM proteins contribute to cancer and the possibility of targeting TRIM-directed autophagy in cancer therapy. |
| first_indexed | 2024-04-13T23:29:38Z |
| format | Article |
| id | doaj.art-3bf6aeafbcb046b6b800e61b682d58a8 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T23:29:38Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-3bf6aeafbcb046b6b800e61b682d58a82022-12-22T02:24:56ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-03-011110.3389/fphar.2020.00308521751The Tripartite Nexus: Autophagy, Cancer, and Tripartite Motif-Containing Protein Family MembersMichael A. Mandell0Michael A. Mandell1Bhaskar Saha2Todd A. Thompson3Todd A. Thompson4Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, United StatesAutophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, United StatesDepartment of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, United StatesAutophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, United StatesDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, United StatesAutophagy is a cellular degradative process that has multiple important actions in cancer. Autophagy modulation is under consideration as a promising new approach to cancer therapy. However, complete autophagy dysregulation is likely to have substantial undesirable side effects. Thus, more targeted approaches to autophagy modulation may prove clinically beneficial. One potential avenue to achieving this goal is to focus on the actions of tripartite motif-containing protein family members (TRIMs). TRIMs have key roles in an array of cellular processes, and their dysregulation has been extensively linked to cancer risk and prognosis. As detailed here, emerging data shows that TRIMs can play important yet context-dependent roles in controlling autophagy and in the selective targeting of autophagic substrates. This review covers how the autophagy-related actions of TRIM proteins contribute to cancer and the possibility of targeting TRIM-directed autophagy in cancer therapy.https://www.frontiersin.org/article/10.3389/fphar.2020.00308/fullautophagycancer therapytripartite motif (TRIM) familySequestosome 1 (p62/SQSTM1)selective autophagy cargo receptorautophagy regulation |
| spellingShingle | Michael A. Mandell Michael A. Mandell Bhaskar Saha Todd A. Thompson Todd A. Thompson The Tripartite Nexus: Autophagy, Cancer, and Tripartite Motif-Containing Protein Family Members Frontiers in Pharmacology autophagy cancer therapy tripartite motif (TRIM) family Sequestosome 1 (p62/SQSTM1) selective autophagy cargo receptor autophagy regulation |
| title | The Tripartite Nexus: Autophagy, Cancer, and Tripartite Motif-Containing Protein Family Members |
| title_full | The Tripartite Nexus: Autophagy, Cancer, and Tripartite Motif-Containing Protein Family Members |
| title_fullStr | The Tripartite Nexus: Autophagy, Cancer, and Tripartite Motif-Containing Protein Family Members |
| title_full_unstemmed | The Tripartite Nexus: Autophagy, Cancer, and Tripartite Motif-Containing Protein Family Members |
| title_short | The Tripartite Nexus: Autophagy, Cancer, and Tripartite Motif-Containing Protein Family Members |
| title_sort | tripartite nexus autophagy cancer and tripartite motif containing protein family members |
| topic | autophagy cancer therapy tripartite motif (TRIM) family Sequestosome 1 (p62/SQSTM1) selective autophagy cargo receptor autophagy regulation |
| url | https://www.frontiersin.org/article/10.3389/fphar.2020.00308/full |
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