Neuroprotection Mechanisms in Cerebral Hypothermia (Review)
The review focuses on the neuroprotective mechanisms of therapeutic hypothermia from the standpoint of metabolic depression and genomic reprogramming of neurons that develop when brain temperature decreases.The concept of hypothermic pre-conditioning based on the development of typical nonspecific r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2019-12-01
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| Series: | Общая реаниматология |
| Subjects: | |
| Online Access: | https://www.reanimatology.com/rmt/article/view/1835 |
| _version_ | 1797874189714063360 |
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| author | Oleg A. Shevelev Marina V. Petrova Shavkat Kh. Saidov Nadezhda A. Khodorovich Pranil Pradkhan |
| author_facet | Oleg A. Shevelev Marina V. Petrova Shavkat Kh. Saidov Nadezhda A. Khodorovich Pranil Pradkhan |
| author_sort | Oleg A. Shevelev |
| collection | DOAJ |
| description | The review focuses on the neuroprotective mechanisms of therapeutic hypothermia from the standpoint of metabolic depression and genomic reprogramming of neurons that develop when brain temperature decreases.The concept of hypothermic pre-conditioning based on the development of typical nonspecific reactions for the formation of the cytoprotective phenotype of neurons due to potentially dangerous stimuli, such as ischemia, reperfusion, and hypothermia, was used to explain the effects of low temperatures. The data confirming the role of therapeutic cerebral hypothermia as a technique of selective brain exposure to mild cold for the neuroprotection and correction of temperature balance disorders are shown.The approach to therapeutic hypothermia as a hypothermic pre-conditioning allows to significantly expand the scope of its use in various procedural variants. |
| first_indexed | 2024-04-10T01:26:58Z |
| format | Article |
| id | doaj.art-3bf71ca6ff92467f8a44a08d8eeb5043 |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2024-04-10T01:26:58Z |
| publishDate | 2019-12-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-3bf71ca6ff92467f8a44a08d8eeb50432023-03-13T09:32:56ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102019-12-011569411410.15360/1813-9779-2019-6-94-1141720Neuroprotection Mechanisms in Cerebral Hypothermia (Review)Oleg A. Shevelev0Marina V. Petrova1Shavkat Kh. Saidov2Nadezhda A. Khodorovich3Pranil Pradkhan4Федеральный научно-клинический центр реаниматологии и реабилитологии; Российский университет дружбы народовФедеральный научно-клинический центр реаниматологии и реабилитологии; Российский университет дружбы народовФедеральный научно-клинический центр реаниматологии и реабилитологииРоссийский университет дружбы народовРоссийский университет дружбы народовThe review focuses on the neuroprotective mechanisms of therapeutic hypothermia from the standpoint of metabolic depression and genomic reprogramming of neurons that develop when brain temperature decreases.The concept of hypothermic pre-conditioning based on the development of typical nonspecific reactions for the formation of the cytoprotective phenotype of neurons due to potentially dangerous stimuli, such as ischemia, reperfusion, and hypothermia, was used to explain the effects of low temperatures. The data confirming the role of therapeutic cerebral hypothermia as a technique of selective brain exposure to mild cold for the neuroprotection and correction of temperature balance disorders are shown.The approach to therapeutic hypothermia as a hypothermic pre-conditioning allows to significantly expand the scope of its use in various procedural variants.https://www.reanimatology.com/rmt/article/view/1835терапевтическая гипотермияпрекондиционированиетепловой балансголовной мозг |
| spellingShingle | Oleg A. Shevelev Marina V. Petrova Shavkat Kh. Saidov Nadezhda A. Khodorovich Pranil Pradkhan Neuroprotection Mechanisms in Cerebral Hypothermia (Review) Общая реаниматология терапевтическая гипотермия прекондиционирование тепловой баланс головной мозг |
| title | Neuroprotection Mechanisms in Cerebral Hypothermia (Review) |
| title_full | Neuroprotection Mechanisms in Cerebral Hypothermia (Review) |
| title_fullStr | Neuroprotection Mechanisms in Cerebral Hypothermia (Review) |
| title_full_unstemmed | Neuroprotection Mechanisms in Cerebral Hypothermia (Review) |
| title_short | Neuroprotection Mechanisms in Cerebral Hypothermia (Review) |
| title_sort | neuroprotection mechanisms in cerebral hypothermia review |
| topic | терапевтическая гипотермия прекондиционирование тепловой баланс головной мозг |
| url | https://www.reanimatology.com/rmt/article/view/1835 |
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