Suppression of Peritoneal Fibrosis by Sonoporation of Hepatocyte Growth Factor Gene-Encoding Plasmid DNA in Mice

Suppression of Peritoneal Fibrosis by Sonoporation of Hepatocyte Growth Factor Gene-Encoding Plasmid DNA in Mice

Gene therapy is expected to be used for the treatment of peritoneal fibrosis, which is a serious problem associated with long-term peritoneal dialysis. Hepatocyte growth factor (HGF) is a well-known anti-fibrotic gene. We developed an ultrasound and nanobubble-mediated (sonoporation) gene transfecti...

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Bibliographic Details
Main Authors: Koyo Nishimura, Koki Ogawa, Maho Kawaguchi, Shintaro Fumoto, Hidefumi Mukai, Shigeru Kawakami
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceutics
Subjects:
nanobubbles
ultrasound
gene therapy
peritoneal fibrosis
multicolor deep imaging
hepatocyte growth factor
Online Access:https://www.mdpi.com/1999-4923/13/1/115

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