A novel intronic circular RNA circFGFR1int2 up-regulates FGFR1 by recruiting transcriptional activators P65/FUS and suppressing miR-4687-5p to promote prostate cancer progression

A novel intronic circular RNA circFGFR1int2 up-regulates FGFR1 by recruiting transcriptional activators P65/FUS and suppressing miR-4687-5p to promote prostate cancer progression

Abstract Fibroblast growth factor receptor 1 (FGFR1) is a core component of the FGFs/FGFR pathway that activates multiple signalling pathways, including ERK1/2, PI3K/AKT, PLCγ, and NF-κB. Aberrant expression of FGFR1 due to gene amplification, chromosome rearrangement, point mutation, and epigenetic...

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Bibliographic Details
Main Authors: Ruyue Wang, Jinjing Zhong, Xiuyi Pan, Zhengzheng Su, Yunyi Xu, Mengni Zhang, Xueqin Chen, Ni Chen, Ting Yu, Qiao Zhou
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Translational Medicine
Subjects:
circRNA
FUS
P65
miRNA
FGFR1
Transcription regulation
Online Access:https://doi.org/10.1186/s12967-023-04718-y

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