The ventral premammillary nucleus links leptin action and reproduction
The amount of body fat and the energy balance are important factors that influence the timing of puberty and the normal reproductive function. Leptin is a key hormone that conveys to the central nervous system information about the individual energy reserve and modulates the hypothalamus-pituitary-g...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-10-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00057/full |
| _version_ | 1818041917446815744 |
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| author | Jose eDonato Carol F Elias |
| author_facet | Jose eDonato Carol F Elias |
| author_sort | Jose eDonato |
| collection | DOAJ |
| description | The amount of body fat and the energy balance are important factors that influence the timing of puberty and the normal reproductive function. Leptin is a key hormone that conveys to the central nervous system information about the individual energy reserve and modulates the hypothalamus-pituitary-gonad axis. Recent findings suggest that the ventral premammillary nucleus (PMV) mediates the effects of leptin as a permissive factor for the onset of puberty and the coordinated secretion of luteinizing hormone during conditions of negative energy balance. Thus, in this review we will summarize the existing literature about the potential role played by PMV neurons in the regulation of the hypothalamus-pituitary-gonad axis. |
| first_indexed | 2024-12-10T08:38:02Z |
| format | Article |
| id | doaj.art-3bfa3e480f6e4dc8867eabda8ee4a611 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-10T08:38:02Z |
| publishDate | 2011-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-3bfa3e480f6e4dc8867eabda8ee4a6112022-12-22T01:55:55ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922011-10-01210.3389/fendo.2011.0005714212The ventral premammillary nucleus links leptin action and reproductionJose eDonato0Carol F Elias1University of Texas Southwestern Medical Center at DallasUniversity of Texas Southwestern Medical Center at DallasThe amount of body fat and the energy balance are important factors that influence the timing of puberty and the normal reproductive function. Leptin is a key hormone that conveys to the central nervous system information about the individual energy reserve and modulates the hypothalamus-pituitary-gonad axis. Recent findings suggest that the ventral premammillary nucleus (PMV) mediates the effects of leptin as a permissive factor for the onset of puberty and the coordinated secretion of luteinizing hormone during conditions of negative energy balance. Thus, in this review we will summarize the existing literature about the potential role played by PMV neurons in the regulation of the hypothalamus-pituitary-gonad axis.http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00057/fullAdiposityHypothalamusLuteinizing HormonePubertyGnRHPMV |
| spellingShingle | Jose eDonato Carol F Elias The ventral premammillary nucleus links leptin action and reproduction Frontiers in Endocrinology Adiposity Hypothalamus Luteinizing Hormone Puberty GnRH PMV |
| title | The ventral premammillary nucleus links leptin action and reproduction |
| title_full | The ventral premammillary nucleus links leptin action and reproduction |
| title_fullStr | The ventral premammillary nucleus links leptin action and reproduction |
| title_full_unstemmed | The ventral premammillary nucleus links leptin action and reproduction |
| title_short | The ventral premammillary nucleus links leptin action and reproduction |
| title_sort | ventral premammillary nucleus links leptin action and reproduction |
| topic | Adiposity Hypothalamus Luteinizing Hormone Puberty GnRH PMV |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00057/full |
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