Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus)
BACKGROUND: Colombia has a high diversity of medicinal plants, including Tachuelo (Zanthoxylum rhoifolium), a tree belonging to the family Rutaceae, which has been attributed an analgesic use by communities of the Colombian southwest. Nevertheless, this species has been scarce studied in Colombia. T...
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| Format: | Article |
| Language: | English |
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Universidad de Antioquia
2020-12-01
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| Series: | Vitae |
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| Online Access: | https://revistas.udea.edu.co/index.php/vitae/article/view/338956 |
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| author | Melany Villegas-Valencia Libardo Andrés González-Reyes Helberg Asencio-Santofimio Jose Oscar Gutierrez-Montes Angelica García Silverio Garzón-Gaviria |
| author_facet | Melany Villegas-Valencia Libardo Andrés González-Reyes Helberg Asencio-Santofimio Jose Oscar Gutierrez-Montes Angelica García Silverio Garzón-Gaviria |
| author_sort | Melany Villegas-Valencia |
| collection | DOAJ |
| description | BACKGROUND: Colombia has a high diversity of medicinal plants, including Tachuelo (Zanthoxylum rhoifolium), a tree belonging to the family Rutaceae, which has been attributed an analgesic use by communities of the Colombian southwest. Nevertheless, this species has been scarce studied in Colombia. The studies have been limited to the isolation of compounds with antifungal and insecticide activity, using the leaves, branches, and bark of the plant in aqueous, and organic extracts. Neither pharmacological tests have been carried out, nor the analgesic and neuromotor activity have been tested from preparations with this plant’s fruits. OBJECTIVES: To evaluate the analgesic and neuromotor effect of the aqueous and hexane extract of the fruits of Z. rhoifolium. METHODS: As there were no preliminary reports of this study, the first observation was made through Irwin’s test. The formalin and the rotarod test were performed to determine the analgesic and motor coordination effects, respectively. RESULTS: All the evaluated treatments demonstrated to generate analgesia, anesthesia, passivity, reduction in the alarm reaction, and have antinociceptive activity in the formalin test; while only the high dose of the nonpolar extract generated a deficit in the motor performance of the rodents in the rotarod test. CONCLUSIONS: the antinociceptive effect of the aqueous and hexane extracts of this species’ fruits was demonstrated. The hexane extract generated a neuromotor effect, which validates the ethnobotanical reports on Z. rhoifolium fruits. |
| first_indexed | 2024-12-14T09:08:39Z |
| format | Article |
| id | doaj.art-3bfa6a18223142dab494cf47d4ec1b44 |
| institution | Directory Open Access Journal |
| issn | 0121-4004 2145-2660 |
| language | English |
| last_indexed | 2024-12-14T09:08:39Z |
| publishDate | 2020-12-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Vitae |
| spelling | doaj.art-3bfa6a18223142dab494cf47d4ec1b442022-12-21T23:08:37ZengUniversidad de AntioquiaVitae0121-40042145-26602020-12-0127310.17533/udea.vitae.v27n3a03Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus)Melany Villegas-Valencia0Libardo Andrés González-Reyes1Helberg Asencio-Santofimio2Jose Oscar Gutierrez-Montes3Angelica García4Silverio Garzón-Gaviria5Pontificia Universidad Javeriana. Universidad del VallePontificia Universidad Javeriana, CaliUniversidad del VallePontificia Universidad Javeriana, Cali.Pontificia Universidad Javeriana, Cali.BACKGROUND: Colombia has a high diversity of medicinal plants, including Tachuelo (Zanthoxylum rhoifolium), a tree belonging to the family Rutaceae, which has been attributed an analgesic use by communities of the Colombian southwest. Nevertheless, this species has been scarce studied in Colombia. The studies have been limited to the isolation of compounds with antifungal and insecticide activity, using the leaves, branches, and bark of the plant in aqueous, and organic extracts. Neither pharmacological tests have been carried out, nor the analgesic and neuromotor activity have been tested from preparations with this plant’s fruits. OBJECTIVES: To evaluate the analgesic and neuromotor effect of the aqueous and hexane extract of the fruits of Z. rhoifolium. METHODS: As there were no preliminary reports of this study, the first observation was made through Irwin’s test. The formalin and the rotarod test were performed to determine the analgesic and motor coordination effects, respectively. RESULTS: All the evaluated treatments demonstrated to generate analgesia, anesthesia, passivity, reduction in the alarm reaction, and have antinociceptive activity in the formalin test; while only the high dose of the nonpolar extract generated a deficit in the motor performance of the rodents in the rotarod test. CONCLUSIONS: the antinociceptive effect of the aqueous and hexane extracts of this species’ fruits was demonstrated. The hexane extract generated a neuromotor effect, which validates the ethnobotanical reports on Z. rhoifolium fruits.https://revistas.udea.edu.co/index.php/vitae/article/view/338956Zanthoxylum rhoifoliumnociceptionneuromotor effectrotarod testnon-polar extractformalin test |
| spellingShingle | Melany Villegas-Valencia Libardo Andrés González-Reyes Helberg Asencio-Santofimio Jose Oscar Gutierrez-Montes Angelica García Silverio Garzón-Gaviria Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus) Vitae Zanthoxylum rhoifolium nociception neuromotor effect rotarod test non-polar extract formalin test |
| title | Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus) |
| title_full | Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus) |
| title_fullStr | Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus) |
| title_full_unstemmed | Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus) |
| title_short | Analgesic and neuromotor effects of two extracts of Zanthoxylum rhoifolium (Rutaceae) in the Swiss albino mouse (Mus musculus) |
| title_sort | analgesic and neuromotor effects of two extracts of zanthoxylum rhoifolium rutaceae in the swiss albino mouse mus musculus |
| topic | Zanthoxylum rhoifolium nociception neuromotor effect rotarod test non-polar extract formalin test |
| url | https://revistas.udea.edu.co/index.php/vitae/article/view/338956 |
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