Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids

Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids

Summary: Recent advances in generating three-dimensional (3D) organoid systems from stem cells offer new possibilities for disease modeling and drug screening because organoids can recapitulate aspects of in vivo architecture and physiology. In this study, we generate isogenic 3D midbrain organoids...

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Bibliographic Details
Main Authors:	Hongwon Kim, Hyeok Ju Park, Hwan Choi, Yujung Chang, Hanseul Park, Jaein Shin, Junyeop Kim, Christopher J. Lengner, Yong Kyu Lee, Jongpil Kim
Format:	Article
Language:	English
Published:	Elsevier 2019-03-01
Series:	Stem Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671119300220

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