Current insights into the interplay between gut microbiota-derived metabolites and metabolic-associated fatty liver disease
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent and challenging disease associated with a significant health and economic burden. MAFLD has been subjected to and widely investigated in many studies; however, the underlying pathogenesis and its progression have yet to unde...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Tzu-Chi Medical Journal |
| Subjects: | |
| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2023;volume=35;issue=4;spage=290;epage=299;aulast=Dongoran |
| _version_ | 1827292328241397760 |
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| author | Rachmad Anres Dongoran Fang-Cen Tu Chin-Hung Liu |
| author_facet | Rachmad Anres Dongoran Fang-Cen Tu Chin-Hung Liu |
| author_sort | Rachmad Anres Dongoran |
| collection | DOAJ |
| description | Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent and challenging disease associated with a significant health and economic burden. MAFLD has been subjected to and widely investigated in many studies; however, the underlying pathogenesis and its progression have yet to understand fully. Furthermore, precise biomarkers for diagnosing and specific drugs for treatment are yet to be discovered. Increasing evidence has proven gut microbiota as the neglected endocrine organ that regulates homeostasis and immune response. Targeting gut microbiota is an essential strategy for metabolic diseases, including MAFLD. Gut microbiota in the gut-liver axis is connected through tight bidirectional links through the biliary tract, portal vein, and systemic circulation, producing gut microbiota metabolites. This review focuses on the specific correlation between gut microbiota metabolites and MAFLD. Gut microbiota metabolites are biologically active in the host and, through subsequent changes and biological activities, provide implications for MAFLD. Based on the review studies, gut-liver axis related-metabolites including short-chain fatty acids, bile acids (BAs), lipopolysaccharide, choline and its metabolites, indole and its derivates, branched-chain amino acids, and methionine cycle derivates was associated with MAFLD and could be promising MAFLD diagnosis biomarkers, as well as the targets for MAFLD new drug discovery. |
| first_indexed | 2024-04-24T13:02:42Z |
| format | Article |
| id | doaj.art-3bfb3fc3cd8e4008a93798a5a2c464b3 |
| institution | Directory Open Access Journal |
| issn | 1016-3190 2223-8956 |
| language | English |
| last_indexed | 2024-04-24T13:02:42Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu-Chi Medical Journal |
| spelling | doaj.art-3bfb3fc3cd8e4008a93798a5a2c464b32024-04-05T10:08:18ZengWolters Kluwer Medknow PublicationsTzu-Chi Medical Journal1016-31902223-89562023-01-0135429029910.4103/tcmj.tcmj_122_23Current insights into the interplay between gut microbiota-derived metabolites and metabolic-associated fatty liver diseaseRachmad Anres DongoranFang-Cen TuChin-Hung LiuMetabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent and challenging disease associated with a significant health and economic burden. MAFLD has been subjected to and widely investigated in many studies; however, the underlying pathogenesis and its progression have yet to understand fully. Furthermore, precise biomarkers for diagnosing and specific drugs for treatment are yet to be discovered. Increasing evidence has proven gut microbiota as the neglected endocrine organ that regulates homeostasis and immune response. Targeting gut microbiota is an essential strategy for metabolic diseases, including MAFLD. Gut microbiota in the gut-liver axis is connected through tight bidirectional links through the biliary tract, portal vein, and systemic circulation, producing gut microbiota metabolites. This review focuses on the specific correlation between gut microbiota metabolites and MAFLD. Gut microbiota metabolites are biologically active in the host and, through subsequent changes and biological activities, provide implications for MAFLD. Based on the review studies, gut-liver axis related-metabolites including short-chain fatty acids, bile acids (BAs), lipopolysaccharide, choline and its metabolites, indole and its derivates, branched-chain amino acids, and methionine cycle derivates was associated with MAFLD and could be promising MAFLD diagnosis biomarkers, as well as the targets for MAFLD new drug discovery.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2023;volume=35;issue=4;spage=290;epage=299;aulast=Dongorangut microbiota-metabolitesgut-liver axismetabolic dysfunction-associated fatty liver disease |
| spellingShingle | Rachmad Anres Dongoran Fang-Cen Tu Chin-Hung Liu Current insights into the interplay between gut microbiota-derived metabolites and metabolic-associated fatty liver disease Tzu-Chi Medical Journal gut microbiota-metabolites gut-liver axis metabolic dysfunction-associated fatty liver disease |
| title | Current insights into the interplay between gut microbiota-derived metabolites and metabolic-associated fatty liver disease |
| title_full | Current insights into the interplay between gut microbiota-derived metabolites and metabolic-associated fatty liver disease |
| title_fullStr | Current insights into the interplay between gut microbiota-derived metabolites and metabolic-associated fatty liver disease |
| title_full_unstemmed | Current insights into the interplay between gut microbiota-derived metabolites and metabolic-associated fatty liver disease |
| title_short | Current insights into the interplay between gut microbiota-derived metabolites and metabolic-associated fatty liver disease |
| title_sort | current insights into the interplay between gut microbiota derived metabolites and metabolic associated fatty liver disease |
| topic | gut microbiota-metabolites gut-liver axis metabolic dysfunction-associated fatty liver disease |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2023;volume=35;issue=4;spage=290;epage=299;aulast=Dongoran |
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