Relative and Absolute Stereochemistry of Diacarperoxides: Antimalarial Norditerpene Endoperoxides from Marine Sponge Diacarnus megaspinorhabdosa
Five new norditerpene endoperoxides, named diacarperoxides H–L (1–5), and a new norditerpene diol, called diacardiol B (6), were isolated from the South China Sea sponge, Diacarnus megaspinorhabdosa. Their structures, including conformations and absolute configurations, were determined by using spec...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-08-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/12/8/4399 |
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| author | Fan Yang Yike Zou Ru-Ping Wang Mark T. Hamann Hong-Jun Zhang Wei-Hua Jiao Bing-Nan Han Shao-Jiang Song Hou-Wen Lin |
| author_facet | Fan Yang Yike Zou Ru-Ping Wang Mark T. Hamann Hong-Jun Zhang Wei-Hua Jiao Bing-Nan Han Shao-Jiang Song Hou-Wen Lin |
| author_sort | Fan Yang |
| collection | DOAJ |
| description | Five new norditerpene endoperoxides, named diacarperoxides H–L (1–5), and a new norditerpene diol, called diacardiol B (6), were isolated from the South China Sea sponge, Diacarnus megaspinorhabdosa. Their structures, including conformations and absolute configurations, were determined by using spectroscopic analyses, computational approaches and chemical degradation. Diacarperoxides H–J (1–3) showed some interesting stereochemical issues, as well as antimalarial activity. |
| first_indexed | 2024-12-10T06:47:30Z |
| format | Article |
| id | doaj.art-3bfccd1f58e14c46bf9cdbbb521966cb |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-12-10T06:47:30Z |
| publishDate | 2014-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-3bfccd1f58e14c46bf9cdbbb521966cb2022-12-22T01:58:38ZengMDPI AGMarine Drugs1660-33972014-08-011284399441610.3390/md12084399md12084399Relative and Absolute Stereochemistry of Diacarperoxides: Antimalarial Norditerpene Endoperoxides from Marine Sponge Diacarnus megaspinorhabdosaFan Yang0Yike Zou1Ru-Ping Wang2Mark T. Hamann3Hong-Jun Zhang4Wei-Hua Jiao5Bing-Nan Han6Shao-Jiang Song7Hou-Wen Lin8Key Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, ChinaDepartment of Pharmacognosy and National Center for Natural Products Research (NCNPR), School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USAKey Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, ChinaDepartment of Pharmacognosy and National Center for Natural Products Research (NCNPR), School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USADujiangyan Center of Aeromedical Assessment and Training of Air Force, Dujiangyan 611830, ChinaKey Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, ChinaKey Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, ChinaSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, ChinaKey Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, ChinaFive new norditerpene endoperoxides, named diacarperoxides H–L (1–5), and a new norditerpene diol, called diacardiol B (6), were isolated from the South China Sea sponge, Diacarnus megaspinorhabdosa. Their structures, including conformations and absolute configurations, were determined by using spectroscopic analyses, computational approaches and chemical degradation. Diacarperoxides H–J (1–3) showed some interesting stereochemical issues, as well as antimalarial activity.http://www.mdpi.com/1660-3397/12/8/4399antimalarialmarine spongeendoperoxide |
| spellingShingle | Fan Yang Yike Zou Ru-Ping Wang Mark T. Hamann Hong-Jun Zhang Wei-Hua Jiao Bing-Nan Han Shao-Jiang Song Hou-Wen Lin Relative and Absolute Stereochemistry of Diacarperoxides: Antimalarial Norditerpene Endoperoxides from Marine Sponge Diacarnus megaspinorhabdosa Marine Drugs antimalarial marine sponge endoperoxide |
| title | Relative and Absolute Stereochemistry of Diacarperoxides: Antimalarial Norditerpene Endoperoxides from Marine Sponge Diacarnus megaspinorhabdosa |
| title_full | Relative and Absolute Stereochemistry of Diacarperoxides: Antimalarial Norditerpene Endoperoxides from Marine Sponge Diacarnus megaspinorhabdosa |
| title_fullStr | Relative and Absolute Stereochemistry of Diacarperoxides: Antimalarial Norditerpene Endoperoxides from Marine Sponge Diacarnus megaspinorhabdosa |
| title_full_unstemmed | Relative and Absolute Stereochemistry of Diacarperoxides: Antimalarial Norditerpene Endoperoxides from Marine Sponge Diacarnus megaspinorhabdosa |
| title_short | Relative and Absolute Stereochemistry of Diacarperoxides: Antimalarial Norditerpene Endoperoxides from Marine Sponge Diacarnus megaspinorhabdosa |
| title_sort | relative and absolute stereochemistry of diacarperoxides antimalarial norditerpene endoperoxides from marine sponge diacarnus megaspinorhabdosa |
| topic | antimalarial marine sponge endoperoxide |
| url | http://www.mdpi.com/1660-3397/12/8/4399 |
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