Transcranial Electromagnetic Treatment Stops Alzheimer’s Disease Cognitive Decline over a 2½-Year Period: A Pilot Study
<b>Background:</b> There is currently no therapeutic that can stop or reverse the progressive memory impairment of Alzheimer’s disease (AD). However, we recently published that 2 months of daily, in-home transcranial electromagnetic treatment (TEMT) reversed the cognitive impairment in e...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Medicines |
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| Online Access: | https://www.mdpi.com/2305-6320/9/8/42 |
| _version_ | 1797431947938496512 |
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| author | Gary Arendash Haitham Abulaban Susan Steen Ross Andel Yanhong Wang Yun Bai Rob Baranowski Jon McGarity Lyle Scritsmier Xiaoyang Lin Ning Shen Ali Aljassabi Yitong Li Chuanhai Cao |
| author_facet | Gary Arendash Haitham Abulaban Susan Steen Ross Andel Yanhong Wang Yun Bai Rob Baranowski Jon McGarity Lyle Scritsmier Xiaoyang Lin Ning Shen Ali Aljassabi Yitong Li Chuanhai Cao |
| author_sort | Gary Arendash |
| collection | DOAJ |
| description | <b>Background:</b> There is currently no therapeutic that can stop or reverse the progressive memory impairment of Alzheimer’s disease (AD). However, we recently published that 2 months of daily, in-home transcranial electromagnetic treatment (TEMT) reversed the cognitive impairment in eight mild/moderate AD subjects. These cognitive enhancements were accompanied by predicted changes in AD markers within both the blood and cerebrospinal fluid (CSF). <b>Methods:</b> In view of these encouraging findings, the initial clinical study was extended twice to encompass a period of 2½ years. The present study reports on the resulting long-term safety, cognitive assessments, and AD marker evaluations from the five subjects who received long-term treatment. <b>Results:</b> TEMT administration was completely safe over the 2½-year period, with no deleterious side effects. In six cognitive/functional tasks (including the ADAS-cog13, Rey AVLT, MMSE, and ADL), no decline in any measure occurred over this 2½-year period. Long-term TEMT induced reductions in the CSF levels of C-reactive protein, p-tau217, Aβ1-40, and Aβ1-42 while modulating CSF oligomeric Aβ levels. In the plasma, long-term TEMT modulated/rebalanced levels of both p-tau217 and total tau. <b>Conclusions:</b> Although only a limited number of AD patients were involved in this study, the results suggest that TEMT can stop the cognitive decline of AD over a period of at least 2½ years and can do so with no safety issues. |
| first_indexed | 2024-03-09T09:52:41Z |
| format | Article |
| id | doaj.art-3bfea4f0385c48b6ae45a6d7ec084555 |
| institution | Directory Open Access Journal |
| issn | 2305-6320 |
| language | English |
| last_indexed | 2024-03-09T09:52:41Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicines |
| spelling | doaj.art-3bfea4f0385c48b6ae45a6d7ec0845552023-12-01T23:58:55ZengMDPI AGMedicines2305-63202022-08-01984210.3390/medicines9080042Transcranial Electromagnetic Treatment Stops Alzheimer’s Disease Cognitive Decline over a 2½-Year Period: A Pilot StudyGary Arendash0Haitham Abulaban1Susan Steen2Ross Andel3Yanhong Wang4Yun Bai5Rob Baranowski6Jon McGarity7Lyle Scritsmier8Xiaoyang Lin9Ning Shen10Ali Aljassabi11Yitong Li12Chuanhai Cao13NeuroEM Therapeutics, Inc., 13231 N. 14th Place, Phoenix, AZ 85022, USAAxiom Clinical Research of Florida, 2919 W. Swann Ave, Tampa, FL 33609, USAAxiom Clinical Research of Florida, 2919 W. Swann Ave, Tampa, FL 33609, USASchool of Aging Studies, University of South Florida, Tampa, FL 33620, USAMegaNano Biotech, 3802 Spectrum Blvd., Tampa, FL 33612, USAMegaNano Biotech, 3802 Spectrum Blvd., Tampa, FL 33612, USALeft Coast Engineering, Escondido, CA 92025, USANeuroEM Therapeutics, Inc., 13231 N. 14th Place, Phoenix, AZ 85022, USANeuroEM Therapeutics, Inc., 13231 N. 14th Place, Phoenix, AZ 85022, USAMegaNano Biotech, 3802 Spectrum Blvd., Tampa, FL 33612, USASchool of Arts & Science, University of South Florida, Tampa, FL 33621, USAMegaNano Biotech, 3802 Spectrum Blvd., Tampa, FL 33612, USAMegaNano Biotech, 3802 Spectrum Blvd., Tampa, FL 33612, USAMegaNano Biotech, 3802 Spectrum Blvd., Tampa, FL 33612, USA<b>Background:</b> There is currently no therapeutic that can stop or reverse the progressive memory impairment of Alzheimer’s disease (AD). However, we recently published that 2 months of daily, in-home transcranial electromagnetic treatment (TEMT) reversed the cognitive impairment in eight mild/moderate AD subjects. These cognitive enhancements were accompanied by predicted changes in AD markers within both the blood and cerebrospinal fluid (CSF). <b>Methods:</b> In view of these encouraging findings, the initial clinical study was extended twice to encompass a period of 2½ years. The present study reports on the resulting long-term safety, cognitive assessments, and AD marker evaluations from the five subjects who received long-term treatment. <b>Results:</b> TEMT administration was completely safe over the 2½-year period, with no deleterious side effects. In six cognitive/functional tasks (including the ADAS-cog13, Rey AVLT, MMSE, and ADL), no decline in any measure occurred over this 2½-year period. Long-term TEMT induced reductions in the CSF levels of C-reactive protein, p-tau217, Aβ1-40, and Aβ1-42 while modulating CSF oligomeric Aβ levels. In the plasma, long-term TEMT modulated/rebalanced levels of both p-tau217 and total tau. <b>Conclusions:</b> Although only a limited number of AD patients were involved in this study, the results suggest that TEMT can stop the cognitive decline of AD over a period of at least 2½ years and can do so with no safety issues.https://www.mdpi.com/2305-6320/9/8/42Alzheimer’s diseaselong-term transcranial electromagnetic treatmentcognitive benefitsAD markers |
| spellingShingle | Gary Arendash Haitham Abulaban Susan Steen Ross Andel Yanhong Wang Yun Bai Rob Baranowski Jon McGarity Lyle Scritsmier Xiaoyang Lin Ning Shen Ali Aljassabi Yitong Li Chuanhai Cao Transcranial Electromagnetic Treatment Stops Alzheimer’s Disease Cognitive Decline over a 2½-Year Period: A Pilot Study Medicines Alzheimer’s disease long-term transcranial electromagnetic treatment cognitive benefits AD markers |
| title | Transcranial Electromagnetic Treatment Stops Alzheimer’s Disease Cognitive Decline over a 2½-Year Period: A Pilot Study |
| title_full | Transcranial Electromagnetic Treatment Stops Alzheimer’s Disease Cognitive Decline over a 2½-Year Period: A Pilot Study |
| title_fullStr | Transcranial Electromagnetic Treatment Stops Alzheimer’s Disease Cognitive Decline over a 2½-Year Period: A Pilot Study |
| title_full_unstemmed | Transcranial Electromagnetic Treatment Stops Alzheimer’s Disease Cognitive Decline over a 2½-Year Period: A Pilot Study |
| title_short | Transcranial Electromagnetic Treatment Stops Alzheimer’s Disease Cognitive Decline over a 2½-Year Period: A Pilot Study |
| title_sort | transcranial electromagnetic treatment stops alzheimer s disease cognitive decline over a 2 1 2 year period a pilot study |
| topic | Alzheimer’s disease long-term transcranial electromagnetic treatment cognitive benefits AD markers |
| url | https://www.mdpi.com/2305-6320/9/8/42 |
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