Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty: a mini review
The gonadotropin-releasing hormone (GnRH) stimulation test is a valuable tool in diagnosing and differentiating causes of early pubertal occurrences. Utility of the test can be limited in some instances, however, including the early phases of pubertal hypothalamic-pituitary-gonadal axis activation,...
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| Format: | Article |
| Language: | English |
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Korean Society of Pediatric Endocrinology
2020-07-01
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| Series: | Annals of Pediatric Endocrinology & Metabolism |
| Subjects: | |
| Online Access: | http://e-apem.org/upload/pdf/apem-2040004-002.pdf |
| _version_ | 1830416187526217728 |
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| author | Siti Nadirah Ab Rahim Julia Omar Tuan Salwani Tuan Ismail |
| author_facet | Siti Nadirah Ab Rahim Julia Omar Tuan Salwani Tuan Ismail |
| author_sort | Siti Nadirah Ab Rahim |
| collection | DOAJ |
| description | The gonadotropin-releasing hormone (GnRH) stimulation test is a valuable tool in diagnosing and differentiating causes of early pubertal occurrences. Utility of the test can be limited in some instances, however, including the early phases of pubertal hypothalamic-pituitary-gonadal axis activation, in girls showing commonly overlapping pictures, and in obese children due to excess circulating estrogen that suppresses luteinizing hormone (LH). A lack of consistent baseline and stimulated gonadotropin cutoffs observed in different studies also contributes to limitations in testing. Nevertheless, early detection of true pathological causes for pubertal disorders is needed to allow prompt treatment and better prognosis. While basal LH can be beneficial as a good screening tool for detecting pubertal disorder, it does not preclude the need for GnRH testing. The aim of this review was to highlight the role of GnRH stimulation tests and varying testing cutoffs in diagnosis of precocious puberty and its classification. |
| first_indexed | 2024-12-20T21:20:19Z |
| format | Article |
| id | doaj.art-3bffc62831a14805b56a2cf5802f3dc4 |
| institution | Directory Open Access Journal |
| issn | 2287-1012 2287-1292 |
| language | English |
| last_indexed | 2024-12-20T21:20:19Z |
| publishDate | 2020-07-01 |
| publisher | Korean Society of Pediatric Endocrinology |
| record_format | Article |
| series | Annals of Pediatric Endocrinology & Metabolism |
| spelling | doaj.art-3bffc62831a14805b56a2cf5802f3dc42022-12-21T19:26:18ZengKorean Society of Pediatric EndocrinologyAnnals of Pediatric Endocrinology & Metabolism2287-10122287-12922020-07-0125315215510.6065/apem.2040004.002835Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty: a mini reviewSiti Nadirah Ab Rahim0Julia Omar1Tuan Salwani Tuan Ismail2 Faculty of Medicine & Defence Health, National Defence University of Malaysia, Kuala Lumpur, Malaysia Chemical Pathology Laborator y, University Sains Malaysia, Kota Bharu, Malaysia Department of Chemical Pathology, University Sains Malaysia, Kota Bharu, MalaysiaThe gonadotropin-releasing hormone (GnRH) stimulation test is a valuable tool in diagnosing and differentiating causes of early pubertal occurrences. Utility of the test can be limited in some instances, however, including the early phases of pubertal hypothalamic-pituitary-gonadal axis activation, in girls showing commonly overlapping pictures, and in obese children due to excess circulating estrogen that suppresses luteinizing hormone (LH). A lack of consistent baseline and stimulated gonadotropin cutoffs observed in different studies also contributes to limitations in testing. Nevertheless, early detection of true pathological causes for pubertal disorders is needed to allow prompt treatment and better prognosis. While basal LH can be beneficial as a good screening tool for detecting pubertal disorder, it does not preclude the need for GnRH testing. The aim of this review was to highlight the role of GnRH stimulation tests and varying testing cutoffs in diagnosis of precocious puberty and its classification.http://e-apem.org/upload/pdf/apem-2040004-002.pdfgonadotropin-releasing hormoneprecocious pubertygnrh analoguespremature thelarche |
| spellingShingle | Siti Nadirah Ab Rahim Julia Omar Tuan Salwani Tuan Ismail Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty: a mini review Annals of Pediatric Endocrinology & Metabolism gonadotropin-releasing hormone precocious puberty gnrh analogues premature thelarche |
| title | Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty: a mini review |
| title_full | Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty: a mini review |
| title_fullStr | Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty: a mini review |
| title_full_unstemmed | Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty: a mini review |
| title_short | Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty: a mini review |
| title_sort | gonadotropin releasing hormone stimulation test and diagnostic cutoff in precocious puberty a mini review |
| topic | gonadotropin-releasing hormone precocious puberty gnrh analogues premature thelarche |
| url | http://e-apem.org/upload/pdf/apem-2040004-002.pdf |
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