Roles of Protein Disulfide Isomerase in Breast Cancer
Protein disulfide isomerase (PDI) is the endoplasmic reticulum (ER)’s most abundant and essential enzyme and serves as the primary catalyst for protein folding. Due to its apparent role in supporting the rapid proliferation of cancer cells, the selective blockade of PDI results in apoptosis through...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/3/745 |
| _version_ | 1797488701789437952 |
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| author | Suhui Yang Chanel Jackson Eduard Karapetyan Pranabananda Dutta Dulcie Kermah Yong Wu Yanyuan Wu John Schloss Jaydutt V. Vadgama |
| author_facet | Suhui Yang Chanel Jackson Eduard Karapetyan Pranabananda Dutta Dulcie Kermah Yong Wu Yanyuan Wu John Schloss Jaydutt V. Vadgama |
| author_sort | Suhui Yang |
| collection | DOAJ |
| description | Protein disulfide isomerase (PDI) is the endoplasmic reticulum (ER)’s most abundant and essential enzyme and serves as the primary catalyst for protein folding. Due to its apparent role in supporting the rapid proliferation of cancer cells, the selective blockade of PDI results in apoptosis through sustained activation of UPR pathways. The functions of PDI, especially in cancers, have been extensively studied over a decade, and recent research has explored the use of PDI inhibitors in the treatment of cancers but with focus areas of other cancers, such as brain or ovarian cancer. In this review, we discuss the roles of PDI members in breast cancer and PDI inhibitors used in breast cancer research. Additionally, a few PDI members may be suggested as potential molecular targets for highly metastatic breast cancers, such as TNBC, that require more attention in future research. |
| first_indexed | 2024-03-10T00:06:04Z |
| format | Article |
| id | doaj.art-3c01716fd66b4c6898d427469ebd3543 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:06:04Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3c01716fd66b4c6898d427469ebd35432023-11-23T16:07:59ZengMDPI AGCancers2072-66942022-01-0114374510.3390/cancers14030745Roles of Protein Disulfide Isomerase in Breast CancerSuhui Yang0Chanel Jackson1Eduard Karapetyan2Pranabananda Dutta3Dulcie Kermah4Yong Wu5Yanyuan Wu6John Schloss7Jaydutt V. Vadgama8Division of Cancer Research and Training, Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USAPost Baccalaureate Pre-Medical Program, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USADivision of Cancer Research and Training, Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USADivision of Cancer Research and Training, Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USAUrban Health Institute, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USADivision of Cancer Research and Training, Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USADivision of Cancer Research and Training, Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USADivision of Cancer Research and Training, Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USADivision of Cancer Research and Training, Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USAProtein disulfide isomerase (PDI) is the endoplasmic reticulum (ER)’s most abundant and essential enzyme and serves as the primary catalyst for protein folding. Due to its apparent role in supporting the rapid proliferation of cancer cells, the selective blockade of PDI results in apoptosis through sustained activation of UPR pathways. The functions of PDI, especially in cancers, have been extensively studied over a decade, and recent research has explored the use of PDI inhibitors in the treatment of cancers but with focus areas of other cancers, such as brain or ovarian cancer. In this review, we discuss the roles of PDI members in breast cancer and PDI inhibitors used in breast cancer research. Additionally, a few PDI members may be suggested as potential molecular targets for highly metastatic breast cancers, such as TNBC, that require more attention in future research.https://www.mdpi.com/2072-6694/14/3/745breast cancertriple-negative breast cancerprotein disulfide isomeraseprotein disulfide isomerase inhibitor |
| spellingShingle | Suhui Yang Chanel Jackson Eduard Karapetyan Pranabananda Dutta Dulcie Kermah Yong Wu Yanyuan Wu John Schloss Jaydutt V. Vadgama Roles of Protein Disulfide Isomerase in Breast Cancer Cancers breast cancer triple-negative breast cancer protein disulfide isomerase protein disulfide isomerase inhibitor |
| title | Roles of Protein Disulfide Isomerase in Breast Cancer |
| title_full | Roles of Protein Disulfide Isomerase in Breast Cancer |
| title_fullStr | Roles of Protein Disulfide Isomerase in Breast Cancer |
| title_full_unstemmed | Roles of Protein Disulfide Isomerase in Breast Cancer |
| title_short | Roles of Protein Disulfide Isomerase in Breast Cancer |
| title_sort | roles of protein disulfide isomerase in breast cancer |
| topic | breast cancer triple-negative breast cancer protein disulfide isomerase protein disulfide isomerase inhibitor |
| url | https://www.mdpi.com/2072-6694/14/3/745 |
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