MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway

MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway

Abstract Background While molecular targeted drugs and other therapies are being developed for many tumors, pancreatic cancer is still considered to be the malignant tumor with the worst prognosis. We started this study to identify prognostic genes and therapeutic targets of pancreatic cancer. Metho...

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Bibliographic Details
Main Authors: Shoichiro Tange, Tomomi Hirano, Masashi Idogawa, Eishu Hirata, Issei Imoto, Takashi Tokino
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Cancer
Subjects:
TCGA
Pancreatic cancer
DNA methylation
C-Myc
mTORC1
Online Access:https://doi.org/10.1186/s12885-022-10433-6

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