Thyroid Axis and Vestibular Physiopathology: From Animal Model to Pathology
A recent work of our group has shown the significant effects of thyroxine treatment on the restoration of postural balance function in a rodent model of acute peripheral vestibulopathy. Based on these findings, we attempt to shed light in this review on the interaction between the hypothalamic–pitui...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/12/9826 |
| _version_ | 1797594341414273024 |
|---|---|
| author | Guillaume Rastoldo Brahim Tighilet |
| author_facet | Guillaume Rastoldo Brahim Tighilet |
| author_sort | Guillaume Rastoldo |
| collection | DOAJ |
| description | A recent work of our group has shown the significant effects of thyroxine treatment on the restoration of postural balance function in a rodent model of acute peripheral vestibulopathy. Based on these findings, we attempt to shed light in this review on the interaction between the hypothalamic–pituitary–thyroid axis and the vestibular system in normal and pathological situations. Pubmed database and relevant websites were searched from inception through to 4 February 2023. All studies relevant to each subsection of this review have been included. After describing the role of thyroid hormones in the development of the inner ear, we investigated the possible link between the thyroid axis and the vestibular system in normal and pathological conditions. The mechanisms and cellular sites of action of thyroid hormones on animal models of vestibulopathy are postulated and therapeutic options are proposed. In view of their pleiotropic action, thyroid hormones represent a target of choice to promote vestibular compensation at different levels. However, very few studies have investigated the relationship between thyroid hormones and the vestibular system. It seems then important to more extensively investigate the link between the endocrine system and the vestibule in order to better understand the vestibular physiopathology and to find new therapeutic leads. |
| first_indexed | 2024-03-11T02:22:21Z |
| format | Article |
| id | doaj.art-3c0403efe136463b801a7da1503a584b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:22:21Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3c0403efe136463b801a7da1503a584b2023-11-18T10:44:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-012412982610.3390/ijms24129826Thyroid Axis and Vestibular Physiopathology: From Animal Model to PathologyGuillaume Rastoldo0Brahim Tighilet1Aix Marseille Université-CNRS, Laboratoire de Neurosciences Cognitives, LNC UMR 7291, 13331 Marseille, FranceAix Marseille Université-CNRS, Laboratoire de Neurosciences Cognitives, LNC UMR 7291, 13331 Marseille, FranceA recent work of our group has shown the significant effects of thyroxine treatment on the restoration of postural balance function in a rodent model of acute peripheral vestibulopathy. Based on these findings, we attempt to shed light in this review on the interaction between the hypothalamic–pituitary–thyroid axis and the vestibular system in normal and pathological situations. Pubmed database and relevant websites were searched from inception through to 4 February 2023. All studies relevant to each subsection of this review have been included. After describing the role of thyroid hormones in the development of the inner ear, we investigated the possible link between the thyroid axis and the vestibular system in normal and pathological conditions. The mechanisms and cellular sites of action of thyroid hormones on animal models of vestibulopathy are postulated and therapeutic options are proposed. In view of their pleiotropic action, thyroid hormones represent a target of choice to promote vestibular compensation at different levels. However, very few studies have investigated the relationship between thyroid hormones and the vestibular system. It seems then important to more extensively investigate the link between the endocrine system and the vestibule in order to better understand the vestibular physiopathology and to find new therapeutic leads.https://www.mdpi.com/1422-0067/24/12/9826thyroxinethyroid hormonesthyroid axisvestibular systemvestibular compensationvertigo |
| spellingShingle | Guillaume Rastoldo Brahim Tighilet Thyroid Axis and Vestibular Physiopathology: From Animal Model to Pathology International Journal of Molecular Sciences thyroxine thyroid hormones thyroid axis vestibular system vestibular compensation vertigo |
| title | Thyroid Axis and Vestibular Physiopathology: From Animal Model to Pathology |
| title_full | Thyroid Axis and Vestibular Physiopathology: From Animal Model to Pathology |
| title_fullStr | Thyroid Axis and Vestibular Physiopathology: From Animal Model to Pathology |
| title_full_unstemmed | Thyroid Axis and Vestibular Physiopathology: From Animal Model to Pathology |
| title_short | Thyroid Axis and Vestibular Physiopathology: From Animal Model to Pathology |
| title_sort | thyroid axis and vestibular physiopathology from animal model to pathology |
| topic | thyroxine thyroid hormones thyroid axis vestibular system vestibular compensation vertigo |
| url | https://www.mdpi.com/1422-0067/24/12/9826 |
| work_keys_str_mv | AT guillaumerastoldo thyroidaxisandvestibularphysiopathologyfromanimalmodeltopathology AT brahimtighilet thyroidaxisandvestibularphysiopathologyfromanimalmodeltopathology |