CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES
Abstract. The aim was to study the contents TGFα, TGFβ1 and VEGF in blood of patients with local frostbites. 50 men with local frostbites of extremities (II-IV degree) in the age up to 17-45 years old were examined. The patients were classified depending on the time elapsing post-lesion (group 1, ea...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/228 |
| _version_ | 1797198076152119296 |
|---|---|
| author | K. G. Shapovalov V. A. Sizonenko Yu. A. Vitkovsky |
| author_facet | K. G. Shapovalov V. A. Sizonenko Yu. A. Vitkovsky |
| author_sort | K. G. Shapovalov |
| collection | DOAJ |
| description | Abstract. The aim was to study the contents TGFα, TGFβ1 and VEGF in blood of patients with local frostbites. 50 men with local frostbites of extremities (II-IV degree) in the age up to 17-45 years old were examined. The patients were classified depending on the time elapsing post-lesion (group 1, early reactive period; group 2, late reactive period; group 3, granulation and epithelization of lesions). Quantitative determination of TGFα, TGFβ1 and VEGF in blood was performed by ELISA techniques. Blood samples were taken at early, late reactive periods and at period of epithelization of local frostbites. It was revealed that the contents of TGFα, TGFβ1 and VEGF were increased in patients’ blood at later terms after local frostbites. VEGF contents in blood of the frostbite patients increased to higher degrees than the values of TGFα and TGFβ1. An imbalance between TGFα, TGFβ1 and VEGF contents in frostbites was observed in cases of lagging repair and unfavorable clinical course. (Med. Immunol., vol. 10, N 4-5, pp 483-485). |
| first_indexed | 2024-03-08T05:51:26Z |
| format | Article |
| id | doaj.art-3c0587a640ee460798dbf00a636a89f8 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:54:06Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-3c0587a640ee460798dbf00a636a89f82024-04-22T13:07:34ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01104-548348510.15789/1563-0625-2008-4-5-483-485225CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITESK. G. Shapovalov0V. A. Sizonenko1Yu. A. Vitkovsky2ГОУ ВПО Читинская Государственная медицинская академия РосздраваГОУ ВПО Читинская Государственная медицинская академия РосздраваГОУ ВПО Читинская Государственная медицинская академия РосздраваAbstract. The aim was to study the contents TGFα, TGFβ1 and VEGF in blood of patients with local frostbites. 50 men with local frostbites of extremities (II-IV degree) in the age up to 17-45 years old were examined. The patients were classified depending on the time elapsing post-lesion (group 1, early reactive period; group 2, late reactive period; group 3, granulation and epithelization of lesions). Quantitative determination of TGFα, TGFβ1 and VEGF in blood was performed by ELISA techniques. Blood samples were taken at early, late reactive periods and at period of epithelization of local frostbites. It was revealed that the contents of TGFα, TGFβ1 and VEGF were increased in patients’ blood at later terms after local frostbites. VEGF contents in blood of the frostbite patients increased to higher degrees than the values of TGFα and TGFβ1. An imbalance between TGFα, TGFβ1 and VEGF contents in frostbites was observed in cases of lagging repair and unfavorable clinical course. (Med. Immunol., vol. 10, N 4-5, pp 483-485).https://www.mimmun.ru/mimmun/article/view/228angiogenesislocal frostbitesgrowth factors |
| spellingShingle | K. G. Shapovalov V. A. Sizonenko Yu. A. Vitkovsky CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES Медицинская иммунология angiogenesis local frostbites growth factors |
| title | CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES |
| title_full | CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES |
| title_fullStr | CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES |
| title_full_unstemmed | CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES |
| title_short | CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES |
| title_sort | contents of angiogenic growth factors in the patients with local frostbites |
| topic | angiogenesis local frostbites growth factors |
| url | https://www.mimmun.ru/mimmun/article/view/228 |
| work_keys_str_mv | AT kgshapovalov contentsofangiogenicgrowthfactorsinthepatientswithlocalfrostbites AT vasizonenko contentsofangiogenicgrowthfactorsinthepatientswithlocalfrostbites AT yuavitkovsky contentsofangiogenicgrowthfactorsinthepatientswithlocalfrostbites |