Can cardiovascular risk management be improved by shared care with general practice to prevent cognitive decline following stroke/TIA? A feasibility randomised controlled trial (SERVED memory)
Abstract Background Cognitive impairment and dementia following cerebrovascular disease are increasingly common in the UK. One potential strategy to prevent post-stroke cognitive decline is multimodal vascular risk factor management. However, its efficacy remains uncertain and its application in vul...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-09-01
|
| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12877-020-01760-z |
| _version_ | 1828532863211929600 |
|---|---|
| author | William J. Davison Phyo K. Myint Yoon K. Loke Garth Ravenhill David Turner Chris Fox Lee Shepstone John F. Potter |
| author_facet | William J. Davison Phyo K. Myint Yoon K. Loke Garth Ravenhill David Turner Chris Fox Lee Shepstone John F. Potter |
| author_sort | William J. Davison |
| collection | DOAJ |
| description | Abstract Background Cognitive impairment and dementia following cerebrovascular disease are increasingly common in the UK. One potential strategy to prevent post-stroke cognitive decline is multimodal vascular risk factor management. However, its efficacy remains uncertain and its application in vulnerable patients with incident cerebrovascular disease and early cognitive impairment has not been assessed. The primary aim of this study was to assess the feasibility of recruitment and retention of patients with early cognitive impairment post-stroke or transient ischaemic attack (TIA) to a trial of enhanced vascular risk factor management combining primary and secondary care. Methods In this single centre, open label trial adults with a recent stroke or TIA and mild cognitive impairment (MCI) were randomised 1:1 to a three-monthly multimodal vascular risk factor intervention jointly delivered by the trial team and General Practitioner (GP), or control (defined as usual care from the GP). Chosen risk factors were blood pressure (BP), total cholesterol, blood glucose (HbA1C) in those with diabetes, and heart rate and adequacy of anticoagulation in those with atrial fibrillation (AF). Similar patients with normal cognition were enrolled in an embedded observational cohort and also received usual care from the GP. Repeat cognitive screening was undertaken in all participants after 12 months. Results Seventy three participants were recruited to the randomised trial and 94 to the observational cohort (21.8% of those screened). From the randomised trial 35/73 (47.9%) dropped out before final follow-up. In all groups guideline based rates of risk factor control were mostly poor at baseline and did not significantly improve during follow-up. The observational cohort demonstrated greater decline in cognitive test scores at 12 months, with no difference between the randomised groups. Conclusions Recruitment to such a study was feasible, but retention of participants was difficult and generally poor rates of risk factor control suggested insufficient application of the intervention. Consequently, successful scaling up of the trial would require protocol changes with less reliance on primary care services. Any future trial should include participants with normal cognition post-stroke as they may be at greatest risk of cognitive decline. Trial registration ISRCTN, ISRCTN42688361 . Registered 16 April 2015. |
| first_indexed | 2024-12-11T22:59:29Z |
| format | Article |
| id | doaj.art-3c0589f37b6245cf9c1fc1346e458622 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-11T22:59:29Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-3c0589f37b6245cf9c1fc1346e4586222022-12-22T00:47:07ZengBMCBMC Geriatrics1471-23182020-09-012011710.1186/s12877-020-01760-zCan cardiovascular risk management be improved by shared care with general practice to prevent cognitive decline following stroke/TIA? A feasibility randomised controlled trial (SERVED memory)William J. Davison0Phyo K. Myint1Yoon K. Loke2Garth Ravenhill3David Turner4Chris Fox5Lee Shepstone6John F. Potter7Ageing and Stroke Medicine, Norwich Medical School, University of East AngliaAgeing Clinical & Experimental Research Team (ACER), Institute of Applied Health Sciences, University of AberdeenNorwich Medical School, University of East AngliaNorfolk and Norwich University HospitalNorwich Medical School, University of East AngliaNorwich Medical School, University of East AngliaNorwich Medical School, University of East AngliaAgeing and Stroke Medicine, Norwich Medical School, University of East AngliaAbstract Background Cognitive impairment and dementia following cerebrovascular disease are increasingly common in the UK. One potential strategy to prevent post-stroke cognitive decline is multimodal vascular risk factor management. However, its efficacy remains uncertain and its application in vulnerable patients with incident cerebrovascular disease and early cognitive impairment has not been assessed. The primary aim of this study was to assess the feasibility of recruitment and retention of patients with early cognitive impairment post-stroke or transient ischaemic attack (TIA) to a trial of enhanced vascular risk factor management combining primary and secondary care. Methods In this single centre, open label trial adults with a recent stroke or TIA and mild cognitive impairment (MCI) were randomised 1:1 to a three-monthly multimodal vascular risk factor intervention jointly delivered by the trial team and General Practitioner (GP), or control (defined as usual care from the GP). Chosen risk factors were blood pressure (BP), total cholesterol, blood glucose (HbA1C) in those with diabetes, and heart rate and adequacy of anticoagulation in those with atrial fibrillation (AF). Similar patients with normal cognition were enrolled in an embedded observational cohort and also received usual care from the GP. Repeat cognitive screening was undertaken in all participants after 12 months. Results Seventy three participants were recruited to the randomised trial and 94 to the observational cohort (21.8% of those screened). From the randomised trial 35/73 (47.9%) dropped out before final follow-up. In all groups guideline based rates of risk factor control were mostly poor at baseline and did not significantly improve during follow-up. The observational cohort demonstrated greater decline in cognitive test scores at 12 months, with no difference between the randomised groups. Conclusions Recruitment to such a study was feasible, but retention of participants was difficult and generally poor rates of risk factor control suggested insufficient application of the intervention. Consequently, successful scaling up of the trial would require protocol changes with less reliance on primary care services. Any future trial should include participants with normal cognition post-stroke as they may be at greatest risk of cognitive decline. Trial registration ISRCTN, ISRCTN42688361 . Registered 16 April 2015.http://link.springer.com/article/10.1186/s12877-020-01760-zCognitive impairmentDementia after strokeVascular dementiaStrokeCerebrovascular disease |
| spellingShingle | William J. Davison Phyo K. Myint Yoon K. Loke Garth Ravenhill David Turner Chris Fox Lee Shepstone John F. Potter Can cardiovascular risk management be improved by shared care with general practice to prevent cognitive decline following stroke/TIA? A feasibility randomised controlled trial (SERVED memory) BMC Geriatrics Cognitive impairment Dementia after stroke Vascular dementia Stroke Cerebrovascular disease |
| title | Can cardiovascular risk management be improved by shared care with general practice to prevent cognitive decline following stroke/TIA? A feasibility randomised controlled trial (SERVED memory) |
| title_full | Can cardiovascular risk management be improved by shared care with general practice to prevent cognitive decline following stroke/TIA? A feasibility randomised controlled trial (SERVED memory) |
| title_fullStr | Can cardiovascular risk management be improved by shared care with general practice to prevent cognitive decline following stroke/TIA? A feasibility randomised controlled trial (SERVED memory) |
| title_full_unstemmed | Can cardiovascular risk management be improved by shared care with general practice to prevent cognitive decline following stroke/TIA? A feasibility randomised controlled trial (SERVED memory) |
| title_short | Can cardiovascular risk management be improved by shared care with general practice to prevent cognitive decline following stroke/TIA? A feasibility randomised controlled trial (SERVED memory) |
| title_sort | can cardiovascular risk management be improved by shared care with general practice to prevent cognitive decline following stroke tia a feasibility randomised controlled trial served memory |
| topic | Cognitive impairment Dementia after stroke Vascular dementia Stroke Cerebrovascular disease |
| url | http://link.springer.com/article/10.1186/s12877-020-01760-z |
| work_keys_str_mv | AT williamjdavison cancardiovascularriskmanagementbeimprovedbysharedcarewithgeneralpracticetopreventcognitivedeclinefollowingstroketiaafeasibilityrandomisedcontrolledtrialservedmemory AT phyokmyint cancardiovascularriskmanagementbeimprovedbysharedcarewithgeneralpracticetopreventcognitivedeclinefollowingstroketiaafeasibilityrandomisedcontrolledtrialservedmemory AT yoonkloke cancardiovascularriskmanagementbeimprovedbysharedcarewithgeneralpracticetopreventcognitivedeclinefollowingstroketiaafeasibilityrandomisedcontrolledtrialservedmemory AT garthravenhill cancardiovascularriskmanagementbeimprovedbysharedcarewithgeneralpracticetopreventcognitivedeclinefollowingstroketiaafeasibilityrandomisedcontrolledtrialservedmemory AT davidturner cancardiovascularriskmanagementbeimprovedbysharedcarewithgeneralpracticetopreventcognitivedeclinefollowingstroketiaafeasibilityrandomisedcontrolledtrialservedmemory AT chrisfox cancardiovascularriskmanagementbeimprovedbysharedcarewithgeneralpracticetopreventcognitivedeclinefollowingstroketiaafeasibilityrandomisedcontrolledtrialservedmemory AT leeshepstone cancardiovascularriskmanagementbeimprovedbysharedcarewithgeneralpracticetopreventcognitivedeclinefollowingstroketiaafeasibilityrandomisedcontrolledtrialservedmemory AT johnfpotter cancardiovascularriskmanagementbeimprovedbysharedcarewithgeneralpracticetopreventcognitivedeclinefollowingstroketiaafeasibilityrandomisedcontrolledtrialservedmemory |