Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis
Hai Wang, Li Bo Man, Guang Lin Huang, Gui Zhong Li, Jian Wei WangDepartment of Urology, Beijing Jishuitan Hospital, Beijing, People’s Republic of China Objective: The aim of this study was to systematically compare the therapeutic effect and safety of tamsulosin with nifedipine in medical...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-03-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://www.dovepress.com/comparative-efficacy-of-tamsulosin-versus-nifedipine-for-distal-ureter-peer-reviewed-article-DDDT |
| _version_ | 1818155468419235840 |
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| author | Wang H Man LB Huang GL Li GZ Wang JW |
| author_facet | Wang H Man LB Huang GL Li GZ Wang JW |
| author_sort | Wang H |
| collection | DOAJ |
| description | Hai Wang, Li Bo Man, Guang Lin Huang, Gui Zhong Li, Jian Wei WangDepartment of Urology, Beijing Jishuitan Hospital, Beijing, People’s Republic of China Objective: The aim of this study was to systematically compare the therapeutic effect and safety of tamsulosin with nifedipine in medical expulsive therapy for distal ureteral calculi.Methods: Databases, including PubMed, EMBASE, the Cochrane Library, and Clinical Trial Register Centers, were comprehensively searched. Relevant randomized controlled trials (RCTs) were selected, and quality assessment was performed according to the Cochrane Handbook. RevMan software was used to analyze the outcome measures, which consisted of expulsion rate, expulsion time, and complications.Results: Twelve RCTs consisting of 4,961 patients were included (tamsulosin group, 2,489 cases; nifedipine group, 2,472 cases). Compared with nifedipine, tamsulosin significantly increased the expulsion rate (risk ratio =1.29, 95% CI [1.25, 1.33], P<0.0001) and reduced the expulsion time (standard mean difference =-0.39, 95% CI [−0.72, −0.05], P=0.02). Regarding safety, tamsulosin was associated with fewer complications than nifedipine (risk ratio =0.45, 95% CI [0.28, 0.72], P=0.0008), and further subgroup analysis showed that tamsulosin was associated with a lower risk of both mild and moderate-to-severe complications.Conclusion: On the bias of current evidence, tamsulosin showed an overall superiority to nifedipine for distal ureteral calculi <10 mm in aspects of expulsion rate, expulsion time, and safety. Tamsulosin was supposed to be the first drug to be recommended to patients willing to receive medical expulsive therapy.Keywords: tamsulosin, nifedipine, medical expulsive therapy, MET, lower urinary calculi |
| first_indexed | 2024-12-11T14:42:53Z |
| format | Article |
| id | doaj.art-3c072a3a5690405882d462acab15af33 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-11T14:42:53Z |
| publishDate | 2016-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-3c072a3a5690405882d462acab15af332022-12-22T01:01:50ZengDove Medical PressDrug Design, Development and Therapy1177-88812016-03-012016Issue 11257126526161Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysisWang HMan LBHuang GLLi GZWang JWHai Wang, Li Bo Man, Guang Lin Huang, Gui Zhong Li, Jian Wei WangDepartment of Urology, Beijing Jishuitan Hospital, Beijing, People’s Republic of China Objective: The aim of this study was to systematically compare the therapeutic effect and safety of tamsulosin with nifedipine in medical expulsive therapy for distal ureteral calculi.Methods: Databases, including PubMed, EMBASE, the Cochrane Library, and Clinical Trial Register Centers, were comprehensively searched. Relevant randomized controlled trials (RCTs) were selected, and quality assessment was performed according to the Cochrane Handbook. RevMan software was used to analyze the outcome measures, which consisted of expulsion rate, expulsion time, and complications.Results: Twelve RCTs consisting of 4,961 patients were included (tamsulosin group, 2,489 cases; nifedipine group, 2,472 cases). Compared with nifedipine, tamsulosin significantly increased the expulsion rate (risk ratio =1.29, 95% CI [1.25, 1.33], P<0.0001) and reduced the expulsion time (standard mean difference =-0.39, 95% CI [−0.72, −0.05], P=0.02). Regarding safety, tamsulosin was associated with fewer complications than nifedipine (risk ratio =0.45, 95% CI [0.28, 0.72], P=0.0008), and further subgroup analysis showed that tamsulosin was associated with a lower risk of both mild and moderate-to-severe complications.Conclusion: On the bias of current evidence, tamsulosin showed an overall superiority to nifedipine for distal ureteral calculi <10 mm in aspects of expulsion rate, expulsion time, and safety. Tamsulosin was supposed to be the first drug to be recommended to patients willing to receive medical expulsive therapy.Keywords: tamsulosin, nifedipine, medical expulsive therapy, MET, lower urinary calculihttps://www.dovepress.com/comparative-efficacy-of-tamsulosin-versus-nifedipine-for-distal-ureter-peer-reviewed-article-DDDTtamsulosinniffedipinemedical expulsive therapyMETlower urinary calculi |
| spellingShingle | Wang H Man LB Huang GL Li GZ Wang JW Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis Drug Design, Development and Therapy tamsulosin niffedipine medical expulsive therapy MET lower urinary calculi |
| title | Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis |
| title_full | Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis |
| title_fullStr | Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis |
| title_full_unstemmed | Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis |
| title_short | Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis |
| title_sort | comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi a meta analysis |
| topic | tamsulosin niffedipine medical expulsive therapy MET lower urinary calculi |
| url | https://www.dovepress.com/comparative-efficacy-of-tamsulosin-versus-nifedipine-for-distal-ureter-peer-reviewed-article-DDDT |
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