Elucidating the progress and impact of ferroptosis in hemorrhagic stroke
Hemorrhagic stroke is a devastating cerebrovascular disease with high morbidity and mortality, for which effective therapies are currently unavailable. Based on different bleeding sites, hemorrhagic stroke can be generally divided into intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2022.1067570/full |
| _version_ | 1797956026723467264 |
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| author | Feixia Pan Weize Xu Jieying Ding Chencen Wang |
| author_facet | Feixia Pan Weize Xu Jieying Ding Chencen Wang |
| author_sort | Feixia Pan |
| collection | DOAJ |
| description | Hemorrhagic stroke is a devastating cerebrovascular disease with high morbidity and mortality, for which effective therapies are currently unavailable. Based on different bleeding sites, hemorrhagic stroke can be generally divided into intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH), whose pathogenesis share some similarity. Ferroptosis is a recently defined programmed cell deaths (PCDs), which is a critical supplement to the hypothesis on the mechanism of nervous system injury after hemorrhagic stroke. Ferroptosis is characterized by distinctive morphological changes of mitochondria and iron-dependent accumulation of lipid peroxides. Moreover, scientists have successfully demonstrated the involvement of ferroptosis in animal models of ICH and SAH, indicating that ferroptosis is a promising target for hemorrhagic stroke therapy. However, the studies on ferroptosis still faces a serious of technical and theoretical challenges. This review systematically elaborates the role of ferroptosis in the pathogenesis of hemorrhagic stroke and puts forward some opinions on the dilemma of ferroptosis research. |
| first_indexed | 2024-04-10T23:42:25Z |
| format | Article |
| id | doaj.art-3c0882c1f2ef40eeab369cc0d8fe7824 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-10T23:42:25Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-3c0882c1f2ef40eeab369cc0d8fe78242023-01-11T05:52:44ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022023-01-011610.3389/fncel.2022.10675701067570Elucidating the progress and impact of ferroptosis in hemorrhagic strokeFeixia Pan0Weize Xu1Jieying Ding2Chencen Wang3Department of Cardiac Surgery, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Cardiac Surgery, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Pharmacy, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Pediatrics, The First People’s Hospital of Yongkang Affiliated to Hangzhou Medical College, Jinhua, ChinaHemorrhagic stroke is a devastating cerebrovascular disease with high morbidity and mortality, for which effective therapies are currently unavailable. Based on different bleeding sites, hemorrhagic stroke can be generally divided into intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH), whose pathogenesis share some similarity. Ferroptosis is a recently defined programmed cell deaths (PCDs), which is a critical supplement to the hypothesis on the mechanism of nervous system injury after hemorrhagic stroke. Ferroptosis is characterized by distinctive morphological changes of mitochondria and iron-dependent accumulation of lipid peroxides. Moreover, scientists have successfully demonstrated the involvement of ferroptosis in animal models of ICH and SAH, indicating that ferroptosis is a promising target for hemorrhagic stroke therapy. However, the studies on ferroptosis still faces a serious of technical and theoretical challenges. This review systematically elaborates the role of ferroptosis in the pathogenesis of hemorrhagic stroke and puts forward some opinions on the dilemma of ferroptosis research.https://www.frontiersin.org/articles/10.3389/fncel.2022.1067570/fullstrokeintracerebral hemorrhagesubarachnoid hemorrhageferroptosistargetlipid peroxidation |
| spellingShingle | Feixia Pan Weize Xu Jieying Ding Chencen Wang Elucidating the progress and impact of ferroptosis in hemorrhagic stroke Frontiers in Cellular Neuroscience stroke intracerebral hemorrhage subarachnoid hemorrhage ferroptosis target lipid peroxidation |
| title | Elucidating the progress and impact of ferroptosis in hemorrhagic stroke |
| title_full | Elucidating the progress and impact of ferroptosis in hemorrhagic stroke |
| title_fullStr | Elucidating the progress and impact of ferroptosis in hemorrhagic stroke |
| title_full_unstemmed | Elucidating the progress and impact of ferroptosis in hemorrhagic stroke |
| title_short | Elucidating the progress and impact of ferroptosis in hemorrhagic stroke |
| title_sort | elucidating the progress and impact of ferroptosis in hemorrhagic stroke |
| topic | stroke intracerebral hemorrhage subarachnoid hemorrhage ferroptosis target lipid peroxidation |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2022.1067570/full |
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