Seroepidemiology of coxsackievirus B5 in infants and children in Jiangsu province, China
Coxsackievirus B5 (CV-B5) is associated with various human diseases such as viral encephalitis, aseptic meningitis, paralysis, herpangina, and hand, foot and mouth disease (HFMD). However, there is currently no effective vaccine against CV-B5.The seroepidemiologic characteristics of CV-B5 remained u...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-01-01
|
| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2017.1384107 |
| _version_ | 1797677536052772864 |
|---|---|
| author | Fan Gao Lianlian Bian Xiaotian Hao Yalin Hu Xin Yao Shiyang Sun Pan Chen Ce Yang Ruixiao Du Jingxin Li Fengcai Zhu Qunying Mao Zhenglun Liang |
| author_facet | Fan Gao Lianlian Bian Xiaotian Hao Yalin Hu Xin Yao Shiyang Sun Pan Chen Ce Yang Ruixiao Du Jingxin Li Fengcai Zhu Qunying Mao Zhenglun Liang |
| author_sort | Fan Gao |
| collection | DOAJ |
| description | Coxsackievirus B5 (CV-B5) is associated with various human diseases such as viral encephalitis, aseptic meningitis, paralysis, herpangina, and hand, foot and mouth disease (HFMD). However, there is currently no effective vaccine against CV-B5.The seroepidemiologic characteristics of CV-B5 remained unknown. A cohort study was carried out in 176 participants aged 6–35 months from January 2012 to January 2014. The serum samples were collected and tested for CV-B5 neutralizing antibodies (NtAbs) four times during these two years. The confirmed enterovirus cases were recorded through the surveillance system, and their throat or rectal swabs were collected for pathogen detection. According to the changes of CV-B5 NtAbs, two CV-B5 epidemics were detected among these participants during the two-year follow-up. Sixty-seven cases out of all participants had seroconversion in CV-B5 NtAbs. During the first epidemic from March 2012 to September 2012, CV-B5 seropositivity rate increased significantly (6.8%, 12/176 vs. 21.6%, 38/176, P = 0.000). The seroconversion rate and geometric mean fold-increase (GMFI) were 18.2% (32/176) and 55.7, respectively; During the second epidemic from September 2012 to January 2014, CV-B5 seropositivity rate also increased (21.6%, 38/176 vs. 38.6%, 68/176, P = 0.000), and the seroconversion rate and GMFI were 19.9% (35/176) and 46.5, respectively. Only one case had CV-B5 associated HFMD during the two-year follow-up, and CV-B5 from the throat swab isolate was GI.D3 subtype, which belonged to the major pandemic strain in mainland China. CV-B5 infection was common in infants and children in Jiangsu province, China. Therefore, it's necessary to strengthen the surveillance on CV-B5 and to understand the epidemic characteristics of CV-B5 infection. |
| first_indexed | 2024-03-11T22:46:35Z |
| format | Article |
| id | doaj.art-3c08a43a9e83489b897d60b3f582c4dc |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:46:35Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-3c08a43a9e83489b897d60b3f582c4dc2023-09-22T08:17:52ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2018-01-01141748010.1080/21645515.2017.13841071384107Seroepidemiology of coxsackievirus B5 in infants and children in Jiangsu province, ChinaFan Gao0Lianlian Bian1Xiaotian Hao2Yalin Hu3Xin Yao4Shiyang Sun5Pan Chen6Ce Yang7Ruixiao Du8Jingxin Li9Fengcai Zhu10Qunying Mao11Zhenglun Liang12National Institutes for Food and Drug ControlNational Institutes for Food and Drug ControlNational Institutes for Food and Drug ControlHualan Biological Engineering IncNational Institutes for Food and Drug ControlNational Institutes for Food and Drug ControlNational Institutes for Food and Drug ControlNational Institutes for Food and Drug ControlNational Institutes for Food and Drug ControlJiangsu Provincial Center for Disease Control and PreventionJiangsu Provincial Center for Disease Control and PreventionNational Institutes for Food and Drug ControlNational Institutes for Food and Drug ControlCoxsackievirus B5 (CV-B5) is associated with various human diseases such as viral encephalitis, aseptic meningitis, paralysis, herpangina, and hand, foot and mouth disease (HFMD). However, there is currently no effective vaccine against CV-B5.The seroepidemiologic characteristics of CV-B5 remained unknown. A cohort study was carried out in 176 participants aged 6–35 months from January 2012 to January 2014. The serum samples were collected and tested for CV-B5 neutralizing antibodies (NtAbs) four times during these two years. The confirmed enterovirus cases were recorded through the surveillance system, and their throat or rectal swabs were collected for pathogen detection. According to the changes of CV-B5 NtAbs, two CV-B5 epidemics were detected among these participants during the two-year follow-up. Sixty-seven cases out of all participants had seroconversion in CV-B5 NtAbs. During the first epidemic from March 2012 to September 2012, CV-B5 seropositivity rate increased significantly (6.8%, 12/176 vs. 21.6%, 38/176, P = 0.000). The seroconversion rate and geometric mean fold-increase (GMFI) were 18.2% (32/176) and 55.7, respectively; During the second epidemic from September 2012 to January 2014, CV-B5 seropositivity rate also increased (21.6%, 38/176 vs. 38.6%, 68/176, P = 0.000), and the seroconversion rate and GMFI were 19.9% (35/176) and 46.5, respectively. Only one case had CV-B5 associated HFMD during the two-year follow-up, and CV-B5 from the throat swab isolate was GI.D3 subtype, which belonged to the major pandemic strain in mainland China. CV-B5 infection was common in infants and children in Jiangsu province, China. Therefore, it's necessary to strengthen the surveillance on CV-B5 and to understand the epidemic characteristics of CV-B5 infection.http://dx.doi.org/10.1080/21645515.2017.1384107coxsackievirus b5cohort studyseroepidemiologyneutralizing antibodieshand foot and mouth disease |
| spellingShingle | Fan Gao Lianlian Bian Xiaotian Hao Yalin Hu Xin Yao Shiyang Sun Pan Chen Ce Yang Ruixiao Du Jingxin Li Fengcai Zhu Qunying Mao Zhenglun Liang Seroepidemiology of coxsackievirus B5 in infants and children in Jiangsu province, China Human Vaccines & Immunotherapeutics coxsackievirus b5 cohort study seroepidemiology neutralizing antibodies hand foot and mouth disease |
| title | Seroepidemiology of coxsackievirus B5 in infants and children in Jiangsu province, China |
| title_full | Seroepidemiology of coxsackievirus B5 in infants and children in Jiangsu province, China |
| title_fullStr | Seroepidemiology of coxsackievirus B5 in infants and children in Jiangsu province, China |
| title_full_unstemmed | Seroepidemiology of coxsackievirus B5 in infants and children in Jiangsu province, China |
| title_short | Seroepidemiology of coxsackievirus B5 in infants and children in Jiangsu province, China |
| title_sort | seroepidemiology of coxsackievirus b5 in infants and children in jiangsu province china |
| topic | coxsackievirus b5 cohort study seroepidemiology neutralizing antibodies hand foot and mouth disease |
| url | http://dx.doi.org/10.1080/21645515.2017.1384107 |
| work_keys_str_mv | AT fangao seroepidemiologyofcoxsackievirusb5ininfantsandchildreninjiangsuprovincechina AT lianlianbian seroepidemiologyofcoxsackievirusb5ininfantsandchildreninjiangsuprovincechina AT xiaotianhao seroepidemiologyofcoxsackievirusb5ininfantsandchildreninjiangsuprovincechina AT yalinhu seroepidemiologyofcoxsackievirusb5ininfantsandchildreninjiangsuprovincechina AT xinyao seroepidemiologyofcoxsackievirusb5ininfantsandchildreninjiangsuprovincechina AT shiyangsun seroepidemiologyofcoxsackievirusb5ininfantsandchildreninjiangsuprovincechina AT panchen seroepidemiologyofcoxsackievirusb5ininfantsandchildreninjiangsuprovincechina AT ceyang seroepidemiologyofcoxsackievirusb5ininfantsandchildreninjiangsuprovincechina AT ruixiaodu seroepidemiologyofcoxsackievirusb5ininfantsandchildreninjiangsuprovincechina AT jingxinli seroepidemiologyofcoxsackievirusb5ininfantsandchildreninjiangsuprovincechina AT fengcaizhu seroepidemiologyofcoxsackievirusb5ininfantsandchildreninjiangsuprovincechina AT qunyingmao seroepidemiologyofcoxsackievirusb5ininfantsandchildreninjiangsuprovincechina AT zhenglunliang seroepidemiologyofcoxsackievirusb5ininfantsandchildreninjiangsuprovincechina |