The use of animal models in rheumatoid arthritis research
The pathological hallmark of rheumatoid arthritis (RA) is a synovial pannus that comprises proliferating and invasive fibroblast-like synoviocytes, infiltrating inflammatory cells, and an associated neoangiogenic response. Animal models have been established to study these pathological features of h...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Yeungnam University College of Medicine, Yeungnam University Institute Medical Science
2023-01-01
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| Series: | Journal of Yeungnam Medical Science |
| Subjects: | |
| Online Access: | http://www.e-jyms.org/upload/pdf/jyms-2022-00773.pdf |
| _version_ | 1827986867937607680 |
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| author | Jin-Sun Kong Gi Heon Jeong Seung-Ah Yoo |
| author_facet | Jin-Sun Kong Gi Heon Jeong Seung-Ah Yoo |
| author_sort | Jin-Sun Kong |
| collection | DOAJ |
| description | The pathological hallmark of rheumatoid arthritis (RA) is a synovial pannus that comprises proliferating and invasive fibroblast-like synoviocytes, infiltrating inflammatory cells, and an associated neoangiogenic response. Animal models have been established to study these pathological features of human RA. Spontaneous and induced animal models of RA primarily reflect inflammatory aspects of the disease. Among various induced animal models, collagen-induced arthritis (CIA) and collagen antibody-induced arthritis (CAIA) models are widely used to study the pathogenesis of RA. Improved transplantation techniques for severe combined immunodeficiency (SCID) mouse models of RA can be used to evaluate the effectiveness of potential therapeutics in human tissues and cells. This review provides basic information on various animal models of RA, including CIA and CAIA. In addition, we describe a SCID mouse coimplantation model that can measure the long-distance migration of human RA synoviocytes and cartilage destruction induced by these cells. |
| first_indexed | 2024-04-09T23:38:11Z |
| format | Article |
| id | doaj.art-3c08f7566dd24be19361f9e7eaad6fb8 |
| institution | Directory Open Access Journal |
| issn | 2799-8010 |
| language | English |
| last_indexed | 2024-04-09T23:38:11Z |
| publishDate | 2023-01-01 |
| publisher | Yeungnam University College of Medicine, Yeungnam University Institute Medical Science |
| record_format | Article |
| series | Journal of Yeungnam Medical Science |
| spelling | doaj.art-3c08f7566dd24be19361f9e7eaad6fb82023-03-19T23:41:34ZengYeungnam University College of Medicine, Yeungnam University Institute Medical ScienceJournal of Yeungnam Medical Science2799-80102023-01-01401232910.12701/jyms.2022.007732756The use of animal models in rheumatoid arthritis researchJin-Sun Kong0Gi Heon Jeong1Seung-Ah Yoo2 Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, KoreaThe pathological hallmark of rheumatoid arthritis (RA) is a synovial pannus that comprises proliferating and invasive fibroblast-like synoviocytes, infiltrating inflammatory cells, and an associated neoangiogenic response. Animal models have been established to study these pathological features of human RA. Spontaneous and induced animal models of RA primarily reflect inflammatory aspects of the disease. Among various induced animal models, collagen-induced arthritis (CIA) and collagen antibody-induced arthritis (CAIA) models are widely used to study the pathogenesis of RA. Improved transplantation techniques for severe combined immunodeficiency (SCID) mouse models of RA can be used to evaluate the effectiveness of potential therapeutics in human tissues and cells. This review provides basic information on various animal models of RA, including CIA and CAIA. In addition, we describe a SCID mouse coimplantation model that can measure the long-distance migration of human RA synoviocytes and cartilage destruction induced by these cells.http://www.e-jyms.org/upload/pdf/jyms-2022-00773.pdfanimal modelscell movementrheumatoid arthritissevere combined immunodeficient micesynoviocytes |
| spellingShingle | Jin-Sun Kong Gi Heon Jeong Seung-Ah Yoo The use of animal models in rheumatoid arthritis research Journal of Yeungnam Medical Science animal models cell movement rheumatoid arthritis severe combined immunodeficient mice synoviocytes |
| title | The use of animal models in rheumatoid arthritis research |
| title_full | The use of animal models in rheumatoid arthritis research |
| title_fullStr | The use of animal models in rheumatoid arthritis research |
| title_full_unstemmed | The use of animal models in rheumatoid arthritis research |
| title_short | The use of animal models in rheumatoid arthritis research |
| title_sort | use of animal models in rheumatoid arthritis research |
| topic | animal models cell movement rheumatoid arthritis severe combined immunodeficient mice synoviocytes |
| url | http://www.e-jyms.org/upload/pdf/jyms-2022-00773.pdf |
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