Evaluation of limited-sampling strategies to calculate AUC(0–24) and the role of CYP3A5 in Chilean pediatric kidney recipients using extended-release tacrolimus

Evaluation of limited-sampling strategies to calculate AUC(0–24) and the role of CYP3A5 in Chilean pediatric kidney recipients using extended-release tacrolimus

Background: Kidney transplantation (KTx) requires immunosuppressive drugs such as Tacrolimus (TAC) which is mainly metabolized by CYP3A5. TAC is routinely monitored by trough levels (C0) although it has not shown to be a reliable marker. The area-under-curve (AUC) is a more realistic measure of drug...

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Bibliographic Details
Main Authors: Carla Galvez, Pía Boza, Mariluz González, Catalina Hormazabal, Marlene Encina, Manuel Azócar, Luis E. Castañeda, Angélica Rojo, María Luisa Ceballos, Paola Krall
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
pediatric kidney transplant
tacrolimus
limited sampling strategies
area under a curve (AUC)
CYP3A5
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1044050/full

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