Research progress of stem cell therapy for endometrial injury
Endometrial damage is an important factor leading to infertility and traditional conventional treatments have limited efficacy. As an emerging technology in recent years, stem cell therapy has provided new hope for the treatment of this disease. By comparing the advantages of stem cells from differe...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422001879 |
| _version_ | 1828142737912758272 |
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| author | Juan Cen Yichen Zhang Yindu Bai Shenqian Ma Chuan Zhang Lin Jin Shaofeng Duan Yanan Du Yuqi Guo |
| author_facet | Juan Cen Yichen Zhang Yindu Bai Shenqian Ma Chuan Zhang Lin Jin Shaofeng Duan Yanan Du Yuqi Guo |
| author_sort | Juan Cen |
| collection | DOAJ |
| description | Endometrial damage is an important factor leading to infertility and traditional conventional treatments have limited efficacy. As an emerging technology in recent years, stem cell therapy has provided new hope for the treatment of this disease. By comparing the advantages of stem cells from different sources, it is believed that menstrual blood endometrial stem cells have a good application prospect as a new source of stem cells. However, the clinical utility of stem cells is still limited by issues such as colonization rates, long-term efficacy, tumor formation, and storage and transportation. This paper summarizes the mechanism by which stem cells repair endometrial damage and clarifies the material basis of their effects from four aspects: replacement of damaged sites, paracrine effects, interaction with growth factors, and other new targets. According to the pathological characteristics and treatment requirements of intrauterine adhesion (IUA), the research work to solve the above problems from the aspects of functional bioscaffold preparation and multi-functional platform construction is also summarized. From the perspective of scaffold materials and component functions, this review will provide a reference for comprehensively optimizing the clinical application of stem cells. |
| first_indexed | 2024-04-11T19:45:52Z |
| format | Article |
| id | doaj.art-3c0c1e49d85f4050b74f47153bb70483 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-11T19:45:52Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-3c0c1e49d85f4050b74f47153bb704832022-12-22T04:06:29ZengElsevierMaterials Today Bio2590-00642022-12-0116100389Research progress of stem cell therapy for endometrial injuryJuan Cen0Yichen Zhang1Yindu Bai2Shenqian Ma3Chuan Zhang4Lin Jin5Shaofeng Duan6Yanan Du7Yuqi Guo8Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China; Key Laboratory of Natural Medicine and Immune Engineering, School of Pharmacy, Henan University, Kaifeng, 475001, ChinaKey Laboratory of Natural Medicine and Immune Engineering, School of Pharmacy, Henan University, Kaifeng, 475001, ChinaKey Laboratory of Natural Medicine and Immune Engineering, School of Pharmacy, Henan University, Kaifeng, 475001, ChinaHenan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China; Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, ChinaSchool of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, Shanghai, 200240, ChinaHenan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China; International Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou Normal University, Zhoukou, 466001, ChinaKey Laboratory of Natural Medicine and Immune Engineering, School of Pharmacy, Henan University, Kaifeng, 475001, China; Corresponding author.Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China; Corresponding author.Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China; Engineering Research Center for Gynecological Oncology Nanomedicine of Henan Province, Zhengzhou, 450003, China; Corresponding author. Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China.Endometrial damage is an important factor leading to infertility and traditional conventional treatments have limited efficacy. As an emerging technology in recent years, stem cell therapy has provided new hope for the treatment of this disease. By comparing the advantages of stem cells from different sources, it is believed that menstrual blood endometrial stem cells have a good application prospect as a new source of stem cells. However, the clinical utility of stem cells is still limited by issues such as colonization rates, long-term efficacy, tumor formation, and storage and transportation. This paper summarizes the mechanism by which stem cells repair endometrial damage and clarifies the material basis of their effects from four aspects: replacement of damaged sites, paracrine effects, interaction with growth factors, and other new targets. According to the pathological characteristics and treatment requirements of intrauterine adhesion (IUA), the research work to solve the above problems from the aspects of functional bioscaffold preparation and multi-functional platform construction is also summarized. From the perspective of scaffold materials and component functions, this review will provide a reference for comprehensively optimizing the clinical application of stem cells.http://www.sciencedirect.com/science/article/pii/S2590006422001879IUAStem cell therapyEndometrial injuryScaffold materialHydrogel |
| spellingShingle | Juan Cen Yichen Zhang Yindu Bai Shenqian Ma Chuan Zhang Lin Jin Shaofeng Duan Yanan Du Yuqi Guo Research progress of stem cell therapy for endometrial injury Materials Today Bio IUA Stem cell therapy Endometrial injury Scaffold material Hydrogel |
| title | Research progress of stem cell therapy for endometrial injury |
| title_full | Research progress of stem cell therapy for endometrial injury |
| title_fullStr | Research progress of stem cell therapy for endometrial injury |
| title_full_unstemmed | Research progress of stem cell therapy for endometrial injury |
| title_short | Research progress of stem cell therapy for endometrial injury |
| title_sort | research progress of stem cell therapy for endometrial injury |
| topic | IUA Stem cell therapy Endometrial injury Scaffold material Hydrogel |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422001879 |
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