Telomerase reverse transcriptase and neurodegenerative diseases
Neurodegenerative diseases (NDs) are chronic conditions that result in progressive damage to the nervous system, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and Amyotrophic lateral sclerosis (ALS). Age is a major risk factor for NDs. Telomere shortening i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165632/full |
| _version_ | 1797857610187145216 |
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| author | Xin Yu Meng-Meng Liu Cai-Yun Zheng Yu-Tong Liu Zhuo Wang Zhan-You Wang |
| author_facet | Xin Yu Meng-Meng Liu Cai-Yun Zheng Yu-Tong Liu Zhuo Wang Zhan-You Wang |
| author_sort | Xin Yu |
| collection | DOAJ |
| description | Neurodegenerative diseases (NDs) are chronic conditions that result in progressive damage to the nervous system, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and Amyotrophic lateral sclerosis (ALS). Age is a major risk factor for NDs. Telomere shortening is a biological marker of cellular aging, and telomerase reverse transcriptase (TERT) has been shown to slow down this process by maintaining telomere length. The blood-brain barrier (BBB) makes the brain a unique immune organ, and while the number of T cells present in the central nervous system is limited, they play an important role in NDs. Research suggests that NDs can be influenced by modulating peripheral T cell immune responses, and that TERT may play a significant role in T cell senescence and NDs. This review focuses on the current state of research on TERT in NDs and explores the potential connections between TERT, T cells, and NDs. Further studies on aging and telomeres may provide valuable insights for developing therapeutic strategies for age-related diseases. |
| first_indexed | 2024-04-09T20:59:30Z |
| format | Article |
| id | doaj.art-3c0e6bf52fac490597612af4d79e856d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T20:59:30Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3c0e6bf52fac490597612af4d79e856d2023-03-29T11:28:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.11656321165632Telomerase reverse transcriptase and neurodegenerative diseasesXin YuMeng-Meng LiuCai-Yun ZhengYu-Tong LiuZhuo WangZhan-You WangNeurodegenerative diseases (NDs) are chronic conditions that result in progressive damage to the nervous system, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and Amyotrophic lateral sclerosis (ALS). Age is a major risk factor for NDs. Telomere shortening is a biological marker of cellular aging, and telomerase reverse transcriptase (TERT) has been shown to slow down this process by maintaining telomere length. The blood-brain barrier (BBB) makes the brain a unique immune organ, and while the number of T cells present in the central nervous system is limited, they play an important role in NDs. Research suggests that NDs can be influenced by modulating peripheral T cell immune responses, and that TERT may play a significant role in T cell senescence and NDs. This review focuses on the current state of research on TERT in NDs and explores the potential connections between TERT, T cells, and NDs. Further studies on aging and telomeres may provide valuable insights for developing therapeutic strategies for age-related diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165632/fulltelomerase reverse transcriptaseagingneurodegenerative diseasesT cellnervous system |
| spellingShingle | Xin Yu Meng-Meng Liu Cai-Yun Zheng Yu-Tong Liu Zhuo Wang Zhan-You Wang Telomerase reverse transcriptase and neurodegenerative diseases Frontiers in Immunology telomerase reverse transcriptase aging neurodegenerative diseases T cell nervous system |
| title | Telomerase reverse transcriptase and neurodegenerative diseases |
| title_full | Telomerase reverse transcriptase and neurodegenerative diseases |
| title_fullStr | Telomerase reverse transcriptase and neurodegenerative diseases |
| title_full_unstemmed | Telomerase reverse transcriptase and neurodegenerative diseases |
| title_short | Telomerase reverse transcriptase and neurodegenerative diseases |
| title_sort | telomerase reverse transcriptase and neurodegenerative diseases |
| topic | telomerase reverse transcriptase aging neurodegenerative diseases T cell nervous system |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165632/full |
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