Volumetric abnormalities of thalamic subnuclei in medication-overuse headache
Abstract Background The thalamus exerts a pivotal role in pain processing and cortical excitability control and a previous voxel-based morphometry study confirmed increased volume in bilateral thalamus in medication-overuse headache (MOH). The aim of this study is to investigate altered thalamic sub...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s10194-017-0791-5 |
| _version_ | 1819208295599046656 |
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| author | Zhiye Chen Zhihua Jia Xiaoyan Chen Mengqi Liu Shuangfeng Liu Lin Ma Shengyuan Yu |
| author_facet | Zhiye Chen Zhihua Jia Xiaoyan Chen Mengqi Liu Shuangfeng Liu Lin Ma Shengyuan Yu |
| author_sort | Zhiye Chen |
| collection | DOAJ |
| description | Abstract Background The thalamus exerts a pivotal role in pain processing and cortical excitability control and a previous voxel-based morphometry study confirmed increased volume in bilateral thalamus in medication-overuse headache (MOH). The aim of this study is to investigate altered thalamic subnuclei volume in MOH compared with normal controls, and to evaluate the relationship of each thalamic subnuclei volume with the clinical variables. Methods High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 27 patients with MOH and 27 normal controls (NC). Thalamic subnuclei templates were created based on Talairach template with MNI space transformation, and the individual thalamic subnuclei templates were generated by applying the deformation field from structural image segment to the thalamic subnuclei templates, and then individual thalamci subnuclei volume were calculated. Results The whole thalamus and each thalamic subnuclei presented increased volume compared with NC (P < 0.05). The correlation analysis demonstrated that the whole thalamus volume and each thalamic subnuclei volume showed a negative relationship with HAMD scores(P < 0.05), and no any correlation with HAMA, VAS score and disease duration (P > 0.05). Conclusion Increased gray matter volume in the whole thalamus and all the thalamus subnuclei may reflect central sensitization and higher-order of pain alteration in MOH. These structural changes in the thalamus may also be influenced by mood disturbances related to the MOH. |
| first_indexed | 2024-12-23T05:37:07Z |
| format | Article |
| id | doaj.art-3c0f8d36f8a94fd4a80d966c74579fa5 |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-12-23T05:37:07Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-3c0f8d36f8a94fd4a80d966c74579fa52022-12-21T17:58:18ZengBMCThe Journal of Headache and Pain1129-23691129-23772017-08-011811710.1186/s10194-017-0791-5Volumetric abnormalities of thalamic subnuclei in medication-overuse headacheZhiye Chen0Zhihua Jia1Xiaoyan Chen2Mengqi Liu3Shuangfeng Liu4Lin Ma5Shengyuan Yu6Department of Radiology, Chinese PLA General HospitalDepartment of Neurology, Chinese PLA General HospitalDepartment of Neurology, Chinese PLA General HospitalDepartment of Radiology, Chinese PLA General HospitalDepartment of Radiology, Chinese PLA General HospitalDepartment of Radiology, Chinese PLA General HospitalDepartment of Neurology, Chinese PLA General HospitalAbstract Background The thalamus exerts a pivotal role in pain processing and cortical excitability control and a previous voxel-based morphometry study confirmed increased volume in bilateral thalamus in medication-overuse headache (MOH). The aim of this study is to investigate altered thalamic subnuclei volume in MOH compared with normal controls, and to evaluate the relationship of each thalamic subnuclei volume with the clinical variables. Methods High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 27 patients with MOH and 27 normal controls (NC). Thalamic subnuclei templates were created based on Talairach template with MNI space transformation, and the individual thalamic subnuclei templates were generated by applying the deformation field from structural image segment to the thalamic subnuclei templates, and then individual thalamci subnuclei volume were calculated. Results The whole thalamus and each thalamic subnuclei presented increased volume compared with NC (P < 0.05). The correlation analysis demonstrated that the whole thalamus volume and each thalamic subnuclei volume showed a negative relationship with HAMD scores(P < 0.05), and no any correlation with HAMA, VAS score and disease duration (P > 0.05). Conclusion Increased gray matter volume in the whole thalamus and all the thalamus subnuclei may reflect central sensitization and higher-order of pain alteration in MOH. These structural changes in the thalamus may also be influenced by mood disturbances related to the MOH.http://link.springer.com/article/10.1186/s10194-017-0791-5Medication-overuse headacheMigraineThalamusMagnetic resonance imaging |
| spellingShingle | Zhiye Chen Zhihua Jia Xiaoyan Chen Mengqi Liu Shuangfeng Liu Lin Ma Shengyuan Yu Volumetric abnormalities of thalamic subnuclei in medication-overuse headache The Journal of Headache and Pain Medication-overuse headache Migraine Thalamus Magnetic resonance imaging |
| title | Volumetric abnormalities of thalamic subnuclei in medication-overuse headache |
| title_full | Volumetric abnormalities of thalamic subnuclei in medication-overuse headache |
| title_fullStr | Volumetric abnormalities of thalamic subnuclei in medication-overuse headache |
| title_full_unstemmed | Volumetric abnormalities of thalamic subnuclei in medication-overuse headache |
| title_short | Volumetric abnormalities of thalamic subnuclei in medication-overuse headache |
| title_sort | volumetric abnormalities of thalamic subnuclei in medication overuse headache |
| topic | Medication-overuse headache Migraine Thalamus Magnetic resonance imaging |
| url | http://link.springer.com/article/10.1186/s10194-017-0791-5 |
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